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The map label for this gene is gmk [H]

Identifier: 167040398

GI number: 167040398

Start: 1765570

End: 1766193

Strand: Reverse

Name: gmk [H]

Synonym: Teth514_1761

Alternate gene names: 167040398

Gene position: 1766193-1765570 (Counterclockwise)

Preceding gene: 167040399

Following gene: 167040397

Centisome position: 71.88

GC content: 33.33

Gene sequence:

>624_bases
GTGTTGTCGAAAAAGAAAAAAGGGTTACTTATTGTACTTTCTGGGCCTTCAGGGGCAGGAAAAGGGACGATATGCAAAGC
TTTGATGGAAAAAGAGAAAGATTTAAAATTGAGTATATCTGCTACTACCCGTCAGCCAAGAAGCGGAGAAATAGAAGGGA
AAAACTATTTTTTTAAATCGGAAGAGGAATTTGAGAAAATGATAGAAAATGATTCTTTTTTAGAATGGGCAAAGGTATAT
GGCCACTACTACGGTACACCGAAGGATTTCGTATTAAAAAATTTAGATGAAGGAAATGATGTGGTTTTAGAGATAGATAT
TCAAGGAGCTTTAAAAATAAAAGAGAAGTTTCCAGAAGGAGTGTTTATTTTCATATTGCCTCCTTCAATGGAAGAATTAA
AAAATAGGATTAAAAAACGGGGGACAGAGACAGAAGAGGAGATAATAAAAAGATTTAAAAGTGCTTATGAGGAATTAAAC
TATGTTTCCAGGTACAATTATGTAGTTATAAATGATAGTGTAGAAGAAGCGGTTGAAAAAATTAAAGCTATAATTATTGC
AGAGAAATGCAGAGTTGATAGAAATAAGGATTTGTACTTAGAAATCAAGGAGGGGTTGGTATGA

Upstream 100 bases:

>100_bases
TGTTCAACCAGAGACCGTAGCTAATCGTCTCAATTCTAACAAGGAGATATTAGAAGATACTTTAGAAGAAGACGAAGAAG
AGGAAGAGTAGGGGGAATTT

Downstream 100 bases:

>100_bases
TTTTATATCCATCAATTGTAGATTTAATGGAAAAAGTAGATAGCAAATATACTTTGTGTTCTTTAGTTGCAAAAAGAGCA
AGACAGCTTATTGCTGGTGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLSKKKKGLLIVLSGPSGAGKGTICKALMEKEKDLKLSISATTRQPRSGEIEGKNYFFKSEEEFEKMIENDSFLEWAKVY
GHYYGTPKDFVLKNLDEGNDVVLEIDIQGALKIKEKFPEGVFIFILPPSMEELKNRIKKRGTETEEEIIKRFKSAYEELN
YVSRYNYVVINDSVEEAVEKIKAIIIAEKCRVDRNKDLYLEIKEGLV

Sequences:

>Translated_207_residues
MLSKKKKGLLIVLSGPSGAGKGTICKALMEKEKDLKLSISATTRQPRSGEIEGKNYFFKSEEEFEKMIENDSFLEWAKVY
GHYYGTPKDFVLKNLDEGNDVVLEIDIQGALKIKEKFPEGVFIFILPPSMEELKNRIKKRGTETEEEIIKRFKSAYEELN
YVSRYNYVVINDSVEEAVEKIKAIIIAEKCRVDRNKDLYLEIKEGLV
>Mature_207_residues
MLSKKKKGLLIVLSGPSGAGKGTICKALMEKEKDLKLSISATTRQPRSGEIEGKNYFFKSEEEFEKMIENDSFLEWAKVY
GHYYGTPKDFVLKNLDEGNDVVLEIDIQGALKIKEKFPEGVFIFILPPSMEELKNRIKKRGTETEEEIIKRFKSAYEELN
YVSRYNYVVINDSVEEAVEKIKAIIIAEKCRVDRNKDLYLEIKEGLV

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=37.5, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI226874833, Length=176, Percent_Identity=37.5, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI4504221, Length=176, Percent_Identity=37.5, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=28.0898876404494, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4557529, Length=152, Percent_Identity=30.9210526315789, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI192447426, Length=152, Percent_Identity=30.9210526315789, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI21361598, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI186972120, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI186700627, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI186700629, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=44.7916666666667, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=43.0232558139535, Blast_Score=138, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=43.0232558139535, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=45.1086956521739, Blast_Score=154, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.9120879120879, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23787; Mature: 23787

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKKKKGLLIVLSGPSGAGKGTICKALMEKEKDLKLSISATTRQPRSGEIEGKNYFFKS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECC
EEEFEKMIENDSFLEWAKVYGHYYGTPKDFVLKNLDEGNDVVLEIDIQGALKIKEKFPEG
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCEEEHHHHCCCC
VFIFILPPSMEELKNRIKKRGTETEEEIIKRFKSAYEELNYVSRYNYVVINDSVEEAVEK
EEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHH
IKAIIIAEKCRVDRNKDLYLEIKEGLV
HHHHHHHHHHCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MLSKKKKGLLIVLSGPSGAGKGTICKALMEKEKDLKLSISATTRQPRSGEIEGKNYFFKS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECC
EEEFEKMIENDSFLEWAKVYGHYYGTPKDFVLKNLDEGNDVVLEIDIQGALKIKEKFPEG
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEECCCEEEHHHHCCCC
VFIFILPPSMEELKNRIKKRGTETEEEIIKRFKSAYEELNYVSRYNYVVINDSVEEAVEK
EEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHH
IKAIIIAEKCRVDRNKDLYLEIKEGLV
HHHHHHHHHHCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]