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The map label for this gene is infB

Identifier: 167040282

GI number: 167040282

Start: 1661574

End: 1663652

Strand: Reverse

Name: infB

Synonym: Teth514_1645

Alternate gene names: 167040282

Gene position: 1663652-1661574 (Counterclockwise)

Preceding gene: 167040283

Following gene: 167040281

Centisome position: 67.7

GC content: 34.87

Gene sequence:

>2079_bases
ATGTCTAAAACAAGAGTTTATGAATTAGCAAAAGAATTAAATTTATCTAGTAAGGACCTTATATCCAAATTAAACGATTT
GGATATAAAAGTTAAAAATCATATGAGCACATTGGAAGATGAAGAAGTAGAGCTGATAATGGATTTATTAAGAGACAAAC
CACAACAAACAGAAGAAGTCCATCAAAAAGAGGAAGAAGATATATTTGAGGACAATTTAGAGGACATAGAAGAAGAAAGA
GTTTATAAAAAGAGCTTTAAAAAAGGTAGCAAAAAAAATAAGAAGAATAACAAAAAAGCGGTTTTAACAGAAGAAAAAGA
AGAGGACGAAATTAAAATAATCACTATTCCTGAGTTTTTGACTGTAAAAGAGTTAGCAGAAAAAATGAAAGTTAATCCTA
CAGAGATAATTAAAAAGTTAATTGCAAAAGGAATAATGGTTACAGTAAATCAACAAATTGACTTTGAAAATGCAGCTAAA
ATTGCTGAAGAATATGGATTTTTAGTAGATAAAGAGGAAGTAAAAGATGAATTAGAAATGTTATTAGAAGAAACGCCCGA
TGATGAAAAAGATTTGCAACCTCGTCCTCCTATTGTCACTGTAATGGGACATGTGGACCACGGTAAAACTTCTTTATTGG
ATGCCATCAGAAATACAAATGTCACTATGAAGGAAATGGGAGGAATTACACAGCACATAGGAGCTTCTGTAGTTGAGATA
AATGATAAAAAAATTGTCTTTTTAGATACACCCGGCCACGAAGCTTTTACTGCTATGAGAGCAAGGGGAGCCAGCATCAC
AGATATTGTCGTGCTAGTAGTAGCCGCAGATGACGGTGTTATGCCTCAAACTGTAGAAGCAATAAACCACGTGAAAGCCG
CCAATGTACCTATGATTGTAGCCATAAACAAAATAGATTTGCCGACTGCAAATCCAGATAGGGTAAAGACAGAGCTAAGT
GAGTTAGGTTTAGTGCCAGAAGAATGGGGAGGAAATACAATTTGTGTACCTGTTTCTGCTAAGAAAAATATAGGTATAGA
TAATCTTTTAGAAATGATTTTGCTGGTTGCTGAAATGGAAGATTTAAAAGCTAATCCAAATAAGCCAGCAAGAGGCACTA
TAATAGAAGCAAAGTTAGAAAAAGGAAAGGGTCCTGTTGCAACTGTCATTGTGCAAAATGGAACTTTGCAAATAGGAGAT
GCTATTTTAGCAGGTACTGTTTATGGAAAAGTAAGGGCAATGCTTGACGATAAAGGCAGAAGAATTAAAAAAGCAGGACC
TTCTATGCCAGTGGAGGTTTTGGGCTTTTCTGAAGTACCAGAAGCCGGAGATAAGCTCATAGTAGTAGAGGACGAGAAAA
AAGCAAGAGAATTAGCAGAAAGACGTAAAGAACTTCAAAAAGAAATGGAACTTAAACGCAAGCAAAAAGTTTCATTAGAG
GACTTATTTAGTCAAATACAGGAAGGTAGTGTAAAAGAGTTAAATATTATCATAAAAGCGGATGTTCAAGGTTCAGTAGA
AGCACTAAAAAAATCCATTGAAGACTTAAGCAACGAAGAAGTTAGAATAAAGGTAATACACGGAGCAGTAGGCGCAATAA
CTGAAACGGATGTTATGCTTGCATCAGCTTCTAATGCCATAATAATAGGTTTCAATGTAAGACCAGAGACTAACGCTAAA
AATCTCGCAGAAAAAGAAAAGGTAGATATAAAGCTTTATCGAATTATATATGAGGCTATTGAAGATATCAAAGCTGCTAT
GAAAGGTCTGTTGGAGCCAAAATATAAAGAAGTAGAGCTAGGAAGAGCAGAAGTTAGAGCTGTTTTCAGAGTACCTGGTG
TAGGAAATGTAGCTGGATGCTATGTGTTAAGTGGTAAGATTTTAAGGAATTCTGATATACGTGTAGTAAGGGATGGTATT
GTAGTTTATGAAGGTAAAATTGCTTCTTTAAAGAGGTTTAAAGACGACGTAAGAGAAGTACAACAAGGATTTGAATGTGG
TATAGGTATAGATAGGTTCAATGACATTAAAGAGGGGGATATAATAGAAGCTTACCAAATGGAAGAAATTCCTCGTTGA

Upstream 100 bases:

>100_bases
ATAGGAAGAGAAATGGTCGGGGTAATTGGTATTACAGATGAAGGATTAGCAAATGTATTATTAGATGCTGCAAAGGAGGA
AAATTATGGAGGTGAATAAT

Downstream 100 bases:

>100_bases
AAGGATGAGTATAATGCAGTACAGGAATAGTCGACTTTCAGAAGAAATGAAAAGAGAAATAAGTAAAATGATTTTAGAAG
AAATTAAAGACCCAAGAATT

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MSKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEVHQKEEEDIFEDNLEDIEEER
VYKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAK
IAEEYGFLVDKEEVKDELEMLLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEI
NDKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIVAINKIDLPTANPDRVKTELS
ELGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEMEDLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGD
AILAGTVYGKVRAMLDDKGRRIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLE
DLFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVMLASASNAIIIGFNVRPETNAK
NLAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVELGRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGI
VVYEGKIASLKRFKDDVREVQQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR

Sequences:

>Translated_692_residues
MSKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEVHQKEEEDIFEDNLEDIEEER
VYKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAK
IAEEYGFLVDKEEVKDELEMLLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEI
NDKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIVAINKIDLPTANPDRVKTELS
ELGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEMEDLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGD
AILAGTVYGKVRAMLDDKGRRIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLE
DLFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVMLASASNAIIIGFNVRPETNAK
NLAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVELGRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGI
VVYEGKIASLKRFKDDVREVQQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR
>Mature_691_residues
SKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEVHQKEEEDIFEDNLEDIEEERV
YKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAKI
AEEYGFLVDKEEVKDELEMLLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEIN
DKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIVAINKIDLPTANPDRVKTELSE
LGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEMEDLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGDA
ILAGTVYGKVRAMLDDKGRRIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLED
LFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVMLASASNAIIIGFNVRPETNAKN
LAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVELGRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGIV
VYEGKIASLKRFKDDVREVQQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family

Homologues:

Organism=Homo sapiens, GI53729339, Length=548, Percent_Identity=41.4233576642336, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI53729337, Length=548, Percent_Identity=41.4233576642336, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI84043963, Length=455, Percent_Identity=30.1098901098901, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI157426893, Length=225, Percent_Identity=27.1111111111111, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1789559, Length=579, Percent_Identity=54.9222797927461, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI2367247, Length=302, Percent_Identity=30.1324503311258, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788922, Length=225, Percent_Identity=29.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI48994988, Length=140, Percent_Identity=35, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790412, Length=128, Percent_Identity=37.5, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789737, Length=128, Percent_Identity=37.5, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994658, Length=557, Percent_Identity=36.8043087971275, Blast_Score=318, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI212656558, Length=561, Percent_Identity=28.5204991087344, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17557151, Length=244, Percent_Identity=29.0983606557377, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=225, Percent_Identity=29.3333333333333, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=657, Percent_Identity=36.986301369863, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319282, Length=559, Percent_Identity=27.1914132379249, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323320, Length=228, Percent_Identity=25.4385964912281, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28572034, Length=535, Percent_Identity=42.2429906542056, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24656849, Length=502, Percent_Identity=29.2828685258964, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI160714833, Length=130, Percent_Identity=46.9230769230769, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI78706572, Length=218, Percent_Identity=28.4403669724771, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24582462, Length=142, Percent_Identity=32.3943661971831, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): IF2_THEPX (B0K1D6)

Other databases:

- EMBL:   CP000923
- RefSeq:   YP_001663267.1
- ProteinModelPortal:   B0K1D6
- SMR:   B0K1D6
- GeneID:   5877981
- GenomeReviews:   CP000923_GR
- KEGG:   tex:Teth514_1645
- HOGENOM:   HBG635083
- OMA:   CESAGPS
- ProtClustDB:   PRK05306
- BioCyc:   TSP1755:TETH514_1645-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00100_B
- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR004161
- InterPro:   IPR009000
- Gene3D:   G3DSA:3.40.50.10050
- PANTHER:   PTHR23115:SF41
- TIGRFAMs:   TIGR00487
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF11987 IF-2; PF04760 IF2_N; SSF52156 TIF_IF2_dom3; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 77134; Mature: 77003

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01176 IF2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEV
CCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
HQKEEEDIFEDNLEDIEEERVYKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHH
TVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAKIAEEYGFLVDKEEVKDELEM
HHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEI
HHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHCCHHHHHCCEEEEE
NDKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIV
CCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEE
AINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEME
EEEEECCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
DLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGDAILAGTVYGKVRAMLDDKGR
HHCCCCCCCCCCCEEEEEHHCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHCCC
RIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLE
CHHHCCCCCCEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVML
HHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
ASASNAIIIGFNVRPETNAKNLAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVEL
EECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGIVVYEGKIASLKRFKDDVREV
CHHHHHEEEECCCCCCCCEEEEEECEEEECCCCEEEECCEEEECCCHHHHHHHHHHHHHH
QQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR
HHHHHCCCCCHHCCCCCCCCCEEHHHHHCCCC
>Mature Secondary Structure 
SKTRVYELAKELNLSSKDLISKLNDLDIKVKNHMSTLEDEEVELIMDLLRDKPQQTEEV
CCHHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
HQKEEEDIFEDNLEDIEEERVYKKSFKKGSKKNKKNNKKAVLTEEKEEDEIKIITIPEFL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHH
TVKELAEKMKVNPTEIIKKLIAKGIMVTVNQQIDFENAAKIAEEYGFLVDKEEVKDELEM
HHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LLEETPDDEKDLQPRPPIVTVMGHVDHGKTSLLDAIRNTNVTMKEMGGITQHIGASVVEI
HHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHCCHHHHHCCEEEEE
NDKKIVFLDTPGHEAFTAMRARGASITDIVVLVVAADDGVMPQTVEAINHVKAANVPMIV
CCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEE
AINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDNLLEMILLVAEME
EEEEECCCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
DLKANPNKPARGTIIEAKLEKGKGPVATVIVQNGTLQIGDAILAGTVYGKVRAMLDDKGR
HHCCCCCCCCCCCEEEEEHHCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHCCC
RIKKAGPSMPVEVLGFSEVPEAGDKLIVVEDEKKARELAERRKELQKEMELKRKQKVSLE
CHHHCCCCCCEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLFSQIQEGSVKELNIIIKADVQGSVEALKKSIEDLSNEEVRIKVIHGAVGAITETDVML
HHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEE
ASASNAIIIGFNVRPETNAKNLAEKEKVDIKLYRIIYEAIEDIKAAMKGLLEPKYKEVEL
EECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GRAEVRAVFRVPGVGNVAGCYVLSGKILRNSDIRVVRDGIVVYEGKIASLKRFKDDVREV
CHHHHHEEEECCCCCCCCEEEEEECEEEECCCCEEEECCEEEECCCHHHHHHHHHHHHHH
QQGFECGIGIDRFNDIKEGDIIEAYQMEEIPR
HHHHHCCCCCHHCCCCCCCCCEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA