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The map label for this gene is mutL [H]

Identifier: 167040249

GI number: 167040249

Start: 1629397

End: 1631241

Strand: Direct

Name: mutL [H]

Synonym: Teth514_1612

Alternate gene names: 167040249

Gene position: 1629397-1631241 (Clockwise)

Preceding gene: 167040248

Following gene: 167040250

Centisome position: 66.31

GC content: 30.24

Gene sequence:

>1845_bases
ATGAATAAAATTCATCTTTTAGATGAAAAGACAATAAATAAAATTTCTGCAGGAGAAGTTGTTGAAAGACCTGCCTCTAT
AGTGAAAGAATTAATTGAAAATTCTATTGACGCTGGAAGCAAAAATATTACAGTGGAAATTTTAGAAGGTGGCATTCCTT
ATATAAAGGTATCTGACGACGGTTGTGGAATGAATGAAATAGACGCCATTTTAGCTTTTGAAAGGCACGCCACCAGCAAG
ATAAAATCTGACAATGACCTTTATAGTATAGGGACATTAGGTTTTAGAGGAGAGGCCTTAGCTAGTATTGCGGCAGTTTC
CCATGTAACTTTACAGACTAAAGAAGAAGGAGCTTTATTTGGTACTAAAGTTGTTGTGGAAGGTGGGAAGGTAGTAGAAA
AAACTACTTGTGGTTGTGCAAAAGGATGTAGTATTGAAGTAAGAGATGTGTTTTTTAATACGCCGGCACGAAGGAAGTTT
TTGAAACGTCCTTCAACAGAGAGTATGTATATAATTGATGTTGTAACTAAATTGTGCCTTTCCCATCCTGAAGTTTCTTT
TAAATATGTAAAAGACAGGAAACTACAGTTTATAACATCAGGTAATGGAAATATAGAAGATGTAATTTTGAGGCTTTTTG
GAAATGAAGTCTACTCTTCTCTTATGTCAGCTTCTTTTGAAAGTGAAGATTTGAAATTAAAGATTTTAGCAGGTAAAAAT
TCTTTAAATTATTCAAATAGGAATATGCAATTTTTCTATGTAAATGGAAGATACGTAAAAAATAAAACCCTCTCGGCCGC
TGTAGATGAAGCTTTTAAGACTTATATACCTGTGAACCGATATCCTGCTGTTTTTTTGTACATGGAAATAGACCCAAGGC
AGATTGATGTGAATATACATCCTTCAAAATTAGAGATAAAATTTTCAGATGAAAGAAGAATTTTTGAAGCTGTTTATAAA
ACTATAAAGGATAGCCTTCATAAATACAACTTGATACCAGAAGTAAAAATTGAAGAAAAGAAAAATATCTTTGAAATTGA
AACTCCAACTATTTCAGCTGAGCAGACGAAATTATACTTGACTTCTTCTGATAAAGAATTAGAAGAGGAAAAAAAGAAAT
TTGACAATGAATTTAAAGGTAAGAATGTTTTTTTAAAAGATAATGTATTAAAAGAAAATAGTAAAAATAGTAGTTTAGAT
AACCATTTGGCTGTTTATGAGGAATATGAACATGAAAAAGAAGAAATAAATAAAAATGACCTTGCTAAAAAAATAAGTGA
TATAAGAATAGTGGGCACATTATTTTCTACTTATATAATCGTAGAAAAGGAAGATGTATTCTATATAATTGACCAACATG
CTGCCCACGAAAGGATTTTATATGAAAAATTTACTTCCCAATATGAAAAAATTCAAACAAGGCAGGTAACATTTCCTATT
GTAGTAGAATTACAACCAAGAGACTTAGAACTTGTTCATCAAGAAAAAGAGCTTTTAAATAAATTAGGTTATGTATTTGA
GGAATTTGGGAACAATTGTATAATATTAAGAGAAGTGCCTGTAATTTTAGGACAGCCAGAAGCAAGGCAGTTATTTATAG
ATATAGTGGAAAAACTTAAAGATAAGGAACTTATCAATAAAATATCCTTAAAAGAAGAAAATATTATAATGATGGCTTGT
AAAGCTGCAGTAAAAGCTATGGATAATTTATCTGAAAAAGAAATTCATAAACTTTTTGATGACTTAAAAATTACAGAAAA
TCCTTATACTTGTCCTCACGGAAGACCTGTTATAATCGCTATAACAAAAACTCAGTTAGAAAAGATGTTTAAAAGAATTA
TGTAA

Upstream 100 bases:

>100_bases
ATATAGCCAATTGCGATGTGGACAACATGACTCCTATTCAAGCTCTAAATTATTTATATGAATTAAAGGAGAAGGCAATC
TCCTTGAGGAGCGGAGTATT

Downstream 100 bases:

>100_bases
TATAAGGGTGATGGGATGGCTATACAAATTGTGCTTATTGTTGGGCCCACAGCCTCTGGCAAGTCTAAATTAGCAGTAGA
CGTGGCAAAAGAATTTAATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDDGCGMNEIDAILAFERHATSK
IKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALFGTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKF
LKRPSTESMYIIDVVTKLCLSHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKN
SLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIHPSKLEIKFSDERRIFEAVYK
TIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYLTSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLD
NHLAVYEEYEHEKEEINKNDLAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPI
VVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLKDKELINKISLKEENIIMMAC
KAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIAITKTQLEKMFKRIM

Sequences:

>Translated_614_residues
MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDDGCGMNEIDAILAFERHATSK
IKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALFGTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKF
LKRPSTESMYIIDVVTKLCLSHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKN
SLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIHPSKLEIKFSDERRIFEAVYK
TIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYLTSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLD
NHLAVYEEYEHEKEEINKNDLAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPI
VVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLKDKELINKISLKEENIIMMAC
KAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIAITKTQLEKMFKRIM
>Mature_614_residues
MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDDGCGMNEIDAILAFERHATSK
IKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALFGTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKF
LKRPSTESMYIIDVVTKLCLSHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKN
SLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIHPSKLEIKFSDERRIFEAVYK
TIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYLTSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLD
NHLAVYEEYEHEKEEINKNDLAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPI
VVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLKDKELINKISLKEENIIMMAC
KAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIAITKTQLEKMFKRIM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=331, Percent_Identity=37.7643504531722, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=30.2593659942363, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=30.2593659942363, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=25.7668711656442, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=25.7668711656442, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=233, Percent_Identity=33.4763948497854, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI189458896, Length=319, Percent_Identity=25.0783699059561, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=28.6666666666667, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI91992162, Length=360, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI91992160, Length=360, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI263191733, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI263191713, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=36.5558912386707, Blast_Score=225, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.0625, Blast_Score=182, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=356, Percent_Identity=25, Blast_Score=128, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=323, Percent_Identity=34.6749226006192, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=365, Percent_Identity=28.7671232876712, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=716, Percent_Identity=22.0670391061453, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=25.6906077348066, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=33.0275229357798, Blast_Score=202, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=27.4509803921569, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70311; Mature: 70311

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDD
CCCEEECCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECCC
GCGMNEIDAILAFERHATSKIKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALF
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHEEEEEECCCCCEE
GTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKFLKRPSTESMYIIDVVTKLCL
EEEEEEECCCEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCEEHHHHHHHHHH
SHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKN
CCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
SLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIH
CCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEC
PSKLEIKFSDERRIFEAVYKTIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCEEEEE
TSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLDNHLAVYEEYEHEKEEINKND
ECCCHHHHHHHHHHCHHCCCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
LAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPI
HHHHHHHHHHEEEHHHEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEEE
VVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLK
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHHHHH
DKELINKISLKEENIIMMACKAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIA
HHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCEECCCCCCCCCCCEEEEE
ITKTQLEKMFKRIM
EEHHHHHHHHHHCC
>Mature Secondary Structure
MNKIHLLDEKTINKISAGEVVERPASIVKELIENSIDAGSKNITVEILEGGIPYIKVSDD
CCCEEECCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECCC
GCGMNEIDAILAFERHATSKIKSDNDLYSIGTLGFRGEALASIAAVSHVTLQTKEEGALF
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHEEEEEECCCCCEE
GTKVVVEGGKVVEKTTCGCAKGCSIEVRDVFFNTPARRKFLKRPSTESMYIIDVVTKLCL
EEEEEEECCCEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCEEHHHHHHHHHH
SHPEVSFKYVKDRKLQFITSGNGNIEDVILRLFGNEVYSSLMSASFESEDLKLKILAGKN
CCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
SLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYIPVNRYPAVFLYMEIDPRQIDVNIH
CCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEC
PSKLEIKFSDERRIFEAVYKTIKDSLHKYNLIPEVKIEEKKNIFEIETPTISAEQTKLYL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCEEEEE
TSSDKELEEEKKKFDNEFKGKNVFLKDNVLKENSKNSSLDNHLAVYEEYEHEKEEINKND
ECCCHHHHHHHHHHCHHCCCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
LAKKISDIRIVGTLFSTYIIVEKEDVFYIIDQHAAHERILYEKFTSQYEKIQTRQVTFPI
HHHHHHHHHHEEEHHHEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEEE
VVELQPRDLELVHQEKELLNKLGYVFEEFGNNCIILREVPVILGQPEARQLFIDIVEKLK
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHHHHH
DKELINKISLKEENIIMMACKAAVKAMDNLSEKEIHKLFDDLKITENPYTCPHGRPVIIA
HHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCEECCCCCCCCCCCEEEEE
ITKTQLEKMFKRIM
EEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA