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The map label for this gene is ispH

Identifier: 167040243

GI number: 167040243

Start: 1622012

End: 1622878

Strand: Direct

Name: ispH

Synonym: Teth514_1606

Alternate gene names: 167040243

Gene position: 1622012-1622878 (Clockwise)

Preceding gene: 167040242

Following gene: 167040244

Centisome position: 66.01

GC content: 32.76

Gene sequence:

>867_bases
ATGAAAATATTGATTGCTGAGTATGCAGGTTTCTGCTTTGGAGTAAAAAGAGCTATTGAAACTGCATATCAGGAAATTGA
AAAAGGTGATGGAAAGAAAATATATACTTTAGGTGAAATTATTCATAATCCACAAGTTATATCGGACTTATCGAAAAAAG
GGGTTAATGTTATTGAAGAAGAAGAGCTGGATAAATTAACTGAGGGCGATAAATTAATTATCCGAAGTCATGGGGTGTCT
AAAAAATTATACGATTTTCTCGCTAAAAAAGGAGTTGAAGTCATAGATGTTACCTGCCCATTTGTAAAAAAGGTACAAAA
TATAGTTTATGAGTACTACCACAAGGGCTACTCTATTATCATTGTAGGAGATAGAAATCATCCAGAAGTAATAGGAGTAA
ACGGATGGTGTGATGACACTGCTTATGTGGTAAATTCAATTGAAGAAGCTTATGAATTACCTCAATTAGAAAAGGCATGT
GCAGTTGCTCAAACTACTCTCATTGAAAAGCATTGGAAAGATATTTTAGAAGTAATAAAGCTAAAAGTTAAAGACCTTAT
TTTTTTTAATACTATATGTGATGCTACACAAAAAAGACAAGATGCTGCTGATGAGCTTTCAAAAAAGGTAGATGTAATGT
TTGTAATTGGGGGAAAACATAGCTCTAATACTCAAAAACTAAAAAAGATATGTGAAAAAAATTGTAAAAACACTTTTCAT
ATAGAAGATGCAGAGGAATTGACTCTTGAGATGGTAAAAGACCATGAGATTATAGGAGTAACAGCAGGAGCTTCAACCCC
CGATTATGTGATAGAGGACGTGATAAAAAAAATTAGATTTTTAAAAGGGGAAGATGGGGATGAGTGA

Upstream 100 bases:

>100_bases
TTTGTAAAATATGCAAATTCTAAACTTTCCTCTAAGCAACTTTCTGTTATTGGGGAAGAAATAATGCAGGAAATTGCAAA
ATTGCTGTAGGAGGTAAAGA

Downstream 100 bases:

>100_bases
TTTTTTAGAAGGTTATACTTTTAAGACGTTGCGACCTGGAGACATTGTCAAGGGAAAAGTGATAAAAGTTTCTGATGAGG
GGATTATTGCAAATATTGAC

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEEEELDKLTEGDKLIIRSHGVS
KKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSIIIVGDRNHPEVIGVNGWCDDTAYVVNSIEEAYELPQLEKAC
AVAQTTLIEKHWKDILEVIKLKVKDLIFFNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEKNCKNTFH
IEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGEDGDE

Sequences:

>Translated_288_residues
MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEEEELDKLTEGDKLIIRSHGVS
KKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSIIIVGDRNHPEVIGVNGWCDDTAYVVNSIEEAYELPQLEKAC
AVAQTTLIEKHWKDILEVIKLKVKDLIFFNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEKNCKNTFH
IEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGEDGDE
>Mature_288_residues
MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEEEELDKLTEGDKLIIRSHGVS
KKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSIIIVGDRNHPEVIGVNGWCDDTAYVVNSIEEAYELPQLEKAC
AVAQTTLIEKHWKDILEVIKLKVKDLIFFNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEKNCKNTFH
IEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGEDGDE

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=290, Percent_Identity=32.7586206896552, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_THEP3 (B0K9L0)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665159.1
- GeneID:   5875252
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1169
- HOGENOM:   HBG335228
- OMA:   HMQVARA
- ProtClustDB:   PRK12360
- BioCyc:   TPSE340099:TETH39_1169-MONOMER
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 32546; Mature: 32546

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEE
CEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHCCCCCHHH
EELDKLTEGDKLIIRSHGVSKKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSII
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCEEEE
IVGDRNHPEVIGVNGWCDDTAYVVNSIEEAYELPQLEKACAVAQTTLIEKHWKDILEVIK
EEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKVKDLIFFNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEKNCKNTFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
IEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGEDGDE
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKILIAEYAGFCFGVKRAIETAYQEIEKGDGKKIYTLGEIIHNPQVISDLSKKGVNVIEE
CEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHCCCCCHHH
EELDKLTEGDKLIIRSHGVSKKLYDFLAKKGVEVIDVTCPFVKKVQNIVYEYYHKGYSII
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCEEEE
IVGDRNHPEVIGVNGWCDDTAYVVNSIEEAYELPQLEKACAVAQTTLIEKHWKDILEVIK
EEECCCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKVKDLIFFNTICDATQKRQDAADELSKKVDVMFVIGGKHSSNTQKLKKICEKNCKNTFH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
IEDAEELTLEMVKDHEIIGVTAGASTPDYVIEDVIKKIRFLKGEDGDE
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA