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The map label for this gene is aroA

Identifier: 167040067

GI number: 167040067

Start: 1462118

End: 1463389

Strand: Direct

Name: aroA

Synonym: Teth514_1427

Alternate gene names: 167040067

Gene position: 1462118-1463389 (Clockwise)

Preceding gene: 167040066

Following gene: 167040068

Centisome position: 59.5

GC content: 35.3

Gene sequence:

>1272_bases
ATGGATATTGAAGTAAAGAAGAAAAGATTTTTAAAAGGTGTTATCTCTGTCCCAGGAGATAAGTCAATATCTCATAGAGC
TGTAATGATTGGGTCAATTGCAGAAGGAATTACAGAGATTGAAAATTTTCTTTTAGGAGAAGATTGTATATCTACTATTA
ACTGTATGAAAAATTTGGGTGTTGACATTGAATTAAAAGGCACAAATGTTAAAGTTCAAGGAAAAGGACTTTATCTAAAT
AAAAGTGAAAAAATTCTTGATGTAGGAAATTCGGGTACTACTATTCGGCTTTTGATGGGTATTCTCGCTGGTCAAAAATT
TGAGACAACGCTTACAGGCGATGATTCTATAAAGAGACGCCCTATGGGAAGAGTGATAACTCCTCTTAGTATGATGGGAG
CGAAAATAGAAGCAAGAGAAGGAAATTTTGCACCTCTTACGGTTTTTGGAAACAAACTTAAAGGCATATATTACAAAATG
CCAATTGCCAGTGCACAGGTTAAGTCCAGTATAATGTTGGCAAGCCTTTACGCCGATGATAAAACGACTATTGAAGAGCC
CTACCCTTCAAGAAATCACACGGAACTCATGTTTAGTTCTTTTGGTGCTAAAGTGGAGGTAAATGGCACAAAAATAACTT
GTTACCCTGGCTACAAATTACAAGGGCAGAAAGTTATTGTACCAGGGGATATATCGTCAGCAGCATATTTTATTGTTGCT
GCAACTCTCGTTCCAAATTCGGAGGTTACTATAAAAAATGTAAATGTAAATCCTACAAGAACCGGTATTATTGATGTGAT
AAAAGAGATGGGAGGAGACATTGTCTTAACAAATGAAAGAACTATAAACAATGAAAAAGTAGCGGATATAACAGTTAAGA
CTTCAAGGCTAAAAGGAATTGAAATTGGAGGAAGTCTTATTCCAAGGCTTATTGATGAAATTCCAGTAATAGCAGTTGCA
GCAGTCTTCGCAGAAGGGAAAACAGTGATAAAAGATGCCGAGGAGTTAAAAGTAAAAGAAAGCAATAGAATAAATACAAT
CACTTCAGAATTAAAGAAAATGGGAGCTAAAATTTTTGAAACAGAAGATGGGATGATTATAGAAGGCACGGGATTTTTGA
AAGGGAATACAGTGGAAAGTTACAATGACCACAGGATTGCCATGTCTTTATGGGTTGCTGGACTTATGGCAGAAGGAGAA
ACTAAGATAAAAAATGCTGAATGTGTAAATATTTCGTATCCGGATTTTTATAAAACCTTTGATATGCTTTAA

Upstream 100 bases:

>100_bases
TGACTTTATTAGTTATTTAGAAAATGATGATATTGAGAGTATACAAAAATTTCTTGAAGATGCGAGAAAATATCGAAACA
CTATAACTTGAGGTGTTGTT

Downstream 100 bases:

>100_bases
TATCATTGGTGATGAATAATCAAAAAATGTAAGTTTTACAAAAAAAAGCAGAACGATGTTATTTTTTTGTCAAACTTTGC
TCTTGAAATCCTATATATTG

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLGVDIELKGTNVKVQGKGLYLN
KSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRRPMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKM
PIASAQVKSSIMLASLYADDKTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVA
ATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGIEIGGSLIPRLIDEIPVIAVA
AVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFETEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGE
TKIKNAECVNISYPDFYKTFDML

Sequences:

>Translated_423_residues
MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLGVDIELKGTNVKVQGKGLYLN
KSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRRPMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKM
PIASAQVKSSIMLASLYADDKTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVA
ATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGIEIGGSLIPRLIDEIPVIAVA
AVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFETEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGE
TKIKNAECVNISYPDFYKTFDML
>Mature_423_residues
MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLGVDIELKGTNVKVQGKGLYLN
KSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRRPMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKM
PIASAQVKSSIMLASLYADDKTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVA
ATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGIEIGGSLIPRLIDEIPVIAVA
AVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFETEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGE
TKIKNAECVNISYPDFYKTFDML

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=431, Percent_Identity=28.538283062645, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789580, Length=410, Percent_Identity=24.390243902439, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320332, Length=457, Percent_Identity=26.9146608315098, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_THEP3 (B0K928)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664977.1
- ProteinModelPortal:   B0K928
- SMR:   B0K928
- GeneID:   5873423
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0986
- HOGENOM:   HBG646626
- OMA:   DVEIRAD
- ProtClustDB:   PRK02427
- BioCyc:   TPSE340099:TETH39_0986-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46151; Mature: 46151

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLG
CCCCHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VDIELKGTNVKVQGKGLYLNKSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRR
CEEEEECCEEEEEECEEEECCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHCC
PMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKMPIASAQVKSSIMLASLYADD
CCCHHCCCHHHHCCEEEECCCCEEEEEEECCCCCCEEEECCCCHHHHHHHEEEEEEECCC
KTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVA
CCCCCCCCCCCCCHHHHHHCCCCEEEECCEEEEEECCCEECCCEEEECCCCCCCEEEEEE
ATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGI
EEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEECEECEE
EIGGSLIPRLIDEIPVIAVAAVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFE
EECHHHHHHHHHHCCHHHHHHHHHCCCHHCCCHHHHEECCCCCHHHHHHHHHHCCCEEEE
TEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGETKIKNAECVNISYPDFYKTF
CCCCEEEEECCEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
DML
CCC
>Mature Secondary Structure
MDIEVKKKRFLKGVISVPGDKSISHRAVMIGSIAEGITEIENFLLGEDCISTINCMKNLG
CCCCHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VDIELKGTNVKVQGKGLYLNKSEKILDVGNSGTTIRLLMGILAGQKFETTLTGDDSIKRR
CEEEEECCEEEEEECEEEECCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHCC
PMGRVITPLSMMGAKIEAREGNFAPLTVFGNKLKGIYYKMPIASAQVKSSIMLASLYADD
CCCHHCCCHHHHCCEEEECCCCEEEEEEECCCCCCEEEECCCCHHHHHHHEEEEEEECCC
KTTIEEPYPSRNHTELMFSSFGAKVEVNGTKITCYPGYKLQGQKVIVPGDISSAAYFIVA
CCCCCCCCCCCCCHHHHHHCCCCEEEECCEEEEEECCCEECCCEEEECCCCCCCEEEEEE
ATLVPNSEVTIKNVNVNPTRTGIIDVIKEMGGDIVLTNERTINNEKVADITVKTSRLKGI
EEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEECEECEE
EIGGSLIPRLIDEIPVIAVAAVFAEGKTVIKDAEELKVKESNRINTITSELKKMGAKIFE
EECHHHHHHHHHHCCHHHHHHHHHCCCHHCCCHHHHEECCCCCHHHHHHHHHHCCCEEEE
TEDGMIIEGTGFLKGNTVESYNDHRIAMSLWVAGLMAEGETKIKNAECVNISYPDFYKTF
CCCCEEEEECCEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
DML
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA