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The map label for this gene is pheA [H]

Identifier: 167040064

GI number: 167040064

Start: 1459404

End: 1460228

Strand: Direct

Name: pheA [H]

Synonym: Teth514_1424

Alternate gene names: 167040064

Gene position: 1459404-1460228 (Clockwise)

Preceding gene: 167040063

Following gene: 167040065

Centisome position: 59.39

GC content: 36.0

Gene sequence:

>825_bases
ATGAAAGTTGGCTATTTGGGTCCTAAAGGAACATTTTCTGAAGAAGCTGTTATAAAATACACGCAAGGTGTTGAAAATTG
TGAAGTTGTAGAGTTTAACACCATTCCGGAGGTAATAAATTGCATAAGCAATGGCTTGTGCGAAGAGGCAGTAATTCCTA
TTGAAAACTCTATTGAAGGTTCTGTAAATGTTGCTGTAGATATGCTGATAAACGACGCAAATGGGATAATGATAAAAGGA
GAGGTAATAATACCTATTTCCCATTGCTTGATTTCGGATGCTCCAGTTGAATTTAAAGATGTACATTGTATACTTTCTCA
TCAGCAGGCAATTGCTCAGTGCAGGGAATATATATCTAAAAAATTTCCCAATGCGGAAGTAAAAGCTACAGACAGTACTG
CCCAAGCAGTCTTAGGTGTCAAATCTAAACCCGGAGTAGTGGCGATAGGTCCTGAAAGAGCAGCTGTTATTTACGGCATG
AGAATAATTGATAGAAACATACAAGATGTGAAAGAAAATTATACGAGATTTTTAATTCTTTCTCAAAAAGATTGGGTTGT
CACAGGTAAAGACAAGACCTCAATAGTATTTTCTGTTCCCAATGTTCCAGGCAGTTTATATAACGCTTTAGGTGTTTTGG
CCAACAAAAAAATTAATATGACAAAAATAGAATCTCGACCTTCAAGGAAAAAACTTGGGGAATATGTTTTTTGGGTGGAC
ATTGAGGGGCATAGAGAAGATGAGATAGTAAAGGATGCCTTAGAGGAGTTAAAAGGTAGAACGGATTTTTTAAAAGTATT
AGGTTCATATCCTAAATTTAAGTAG

Upstream 100 bases:

>100_bases
TTTTCTTTATCTTTTTTAGACTTTATGAAAAATTTACTTGACTTTACTTATGCAAAGTATTAAAATATCACCAATATTAT
AAATTGCAAGGGGGTGTTGG

Downstream 100 bases:

>100_bases
AACGGTAGAATGGAGGAATTGAAAATGGTAATTGTTATGAATATTGATGCCACTGATAAGCAAATCTCTGATATTACAAA
TCTTTTAACATCTCTCGGTT

Product: prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKVGYLGPKGTFSEEAVIKYTQGVENCEVVEFNTIPEVINCISNGLCEEAVIPIENSIEGSVNVAVDMLINDANGIMIKG
EVIIPISHCLISDAPVEFKDVHCILSHQQAIAQCREYISKKFPNAEVKATDSTAQAVLGVKSKPGVVAIGPERAAVIYGM
RIIDRNIQDVKENYTRFLILSQKDWVVTGKDKTSIVFSVPNVPGSLYNALGVLANKKINMTKIESRPSRKKLGEYVFWVD
IEGHREDEIVKDALEELKGRTDFLKVLGSYPKFK

Sequences:

>Translated_274_residues
MKVGYLGPKGTFSEEAVIKYTQGVENCEVVEFNTIPEVINCISNGLCEEAVIPIENSIEGSVNVAVDMLINDANGIMIKG
EVIIPISHCLISDAPVEFKDVHCILSHQQAIAQCREYISKKFPNAEVKATDSTAQAVLGVKSKPGVVAIGPERAAVIYGM
RIIDRNIQDVKENYTRFLILSQKDWVVTGKDKTSIVFSVPNVPGSLYNALGVLANKKINMTKIESRPSRKKLGEYVFWVD
IEGHREDEIVKDALEELKGRTDFLKVLGSYPKFK
>Mature_274_residues
MKVGYLGPKGTFSEEAVIKYTQGVENCEVVEFNTIPEVINCISNGLCEEAVIPIENSIEGSVNVAVDMLINDANGIMIKG
EVIIPISHCLISDAPVEFKDVHCILSHQQAIAQCREYISKKFPNAEVKATDSTAQAVLGVKSKPGVVAIGPERAAVIYGM
RIIDRNIQDVKENYTRFLILSQKDWVVTGKDKTSIVFSVPNVPGSLYNALGVLANKKINMTKIESRPSRKKLGEYVFWVD
IEGHREDEIVKDALEELKGRTDFLKVLGSYPKFK

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=280, Percent_Identity=31.0714285714286, Blast_Score=154, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324013, Length=325, Percent_Identity=27.6923076923077, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 30302; Mature: 30302

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGYLGPKGTFSEEAVIKYTQGVENCEVVEFNTIPEVINCISNGLCEEAVIPIENSIEG
CCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCC
SVNVAVDMLINDANGIMIKGEVIIPISHCLISDAPVEFKDVHCILSHQQAIAQCREYISK
CEEEEEEEEEECCCCEEEECEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFPNAEVKATDSTAQAVLGVKSKPGVVAIGPERAAVIYGMRIIDRNIQDVKENYTRFLIL
HCCCCEEEECCHHHHHHEECCCCCCEEEECCCCEEEEEHHHHHHCCHHHHHHCCEEEEEE
SQKDWVVTGKDKTSIVFSVPNVPGSLYNALGVLANKKINMTKIESRPSRKKLGEYVFWVD
ECCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCEEEEEE
IEGHREDEIVKDALEELKGRTDFLKVLGSYPKFK
ECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVGYLGPKGTFSEEAVIKYTQGVENCEVVEFNTIPEVINCISNGLCEEAVIPIENSIEG
CCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCC
SVNVAVDMLINDANGIMIKGEVIIPISHCLISDAPVEFKDVHCILSHQQAIAQCREYISK
CEEEEEEEEEECCCCEEEECEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFPNAEVKATDSTAQAVLGVKSKPGVVAIGPERAAVIYGMRIIDRNIQDVKENYTRFLIL
HCCCCEEEECCHHHHHHEECCCCCCEEEECCCCEEEEEHHHHHHCCHHHHHHCCEEEEEE
SQKDWVVTGKDKTSIVFSVPNVPGSLYNALGVLANKKINMTKIESRPSRKKLGEYVFWVD
ECCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCEEEEEE
IEGHREDEIVKDALEELKGRTDFLKVLGSYPKFK
ECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]