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The map label for this gene is moeB [H]

Identifier: 167040024

GI number: 167040024

Start: 1424554

End: 1425231

Strand: Direct

Name: moeB [H]

Synonym: Teth514_1383

Alternate gene names: 167040024

Gene position: 1424554-1425231 (Clockwise)

Preceding gene: 167040023

Following gene: 167040025

Centisome position: 57.97

GC content: 35.4

Gene sequence:

>678_bases
ATGGGAAGATACGACAGAAATATGAATATGCTATCTAAGGAAGAAAATGAAAAACTAAAGGACTTCAGGGTTTGTGTATT
GGGATGTGGAGGATTGGGTGGGTATGCTATTGAAATGCTTGGTAGATTAGGTATAGGATATATAACTGCAGTTGATAAGG
ATGTTTTTGAGGAAACGAATTTAAACCGCCAGATTTTAAGTGATATGAATTCATTGGGTAAAAGTAAAGCATTAATGGCG
GTGGAAAGAATGAAACTTGTCAACCCAGAAGTTTTTGTAAATGCTATTGTAGATGAATTTAATTTTGAAAATGGAAAAGA
TATCATAAAAGGACATGATATTGTAATCGATGCTCTTGATAATATTGAGGGAAAGCTTACTTTACAGGATATCTGCGAGG
AGCTTGGCATTCCATTTGTTCATGGTGCTATTGCGGGCTGGTATGGGCAGGTTACTACAGTTTTTCCTGGCGATAAGACG
CTTAAGTTTTTGTATAAAAAAGAAATGAGGAAGGGAATTGAAAAAGAACTTGGCAATCCTTCGTTCACTCCTGCTCTTGT
TGCTTCCATTCAAGTTAGTGAAGCACTAAAAGTTTTGATAGGAAGAGGAGAAGTATTAAGACGTAAGGTGTTATTTATAA
ATACCTTTGAGCAAGAATATGAGATTATAGTTCTTTGA

Upstream 100 bases:

>100_bases
TAAATGGACTTGATGGGAAGCTTGATGATCCTCTTAGTGATGGAGATGTGATTTCCCTTTTTCCACCTGTTGGTGGTGGT
TGAGGGAAAGGAGTGTCTTT

Downstream 100 bases:

>100_bases
AATTGGTGTACTATTGTAACGAAAGGACGAAATAAACTTAATATTTTATTACTTATTCTCCGAGTCTATAATCCTAAGGC
AAGAGCTATGGATTATAGGC

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MGRYDRNMNMLSKEENEKLKDFRVCVLGCGGLGGYAIEMLGRLGIGYITAVDKDVFEETNLNRQILSDMNSLGKSKALMA
VERMKLVNPEVFVNAIVDEFNFENGKDIIKGHDIVIDALDNIEGKLTLQDICEELGIPFVHGAIAGWYGQVTTVFPGDKT
LKFLYKKEMRKGIEKELGNPSFTPALVASIQVSEALKVLIGRGEVLRRKVLFINTFEQEYEIIVL

Sequences:

>Translated_225_residues
MGRYDRNMNMLSKEENEKLKDFRVCVLGCGGLGGYAIEMLGRLGIGYITAVDKDVFEETNLNRQILSDMNSLGKSKALMA
VERMKLVNPEVFVNAIVDEFNFENGKDIIKGHDIVIDALDNIEGKLTLQDICEELGIPFVHGAIAGWYGQVTTVFPGDKT
LKFLYKKEMRKGIEKELGNPSFTPALVASIQVSEALKVLIGRGEVLRRKVLFINTFEQEYEIIVL
>Mature_224_residues
GRYDRNMNMLSKEENEKLKDFRVCVLGCGGLGGYAIEMLGRLGIGYITAVDKDVFEETNLNRQILSDMNSLGKSKALMAV
ERMKLVNPEVFVNAIVDEFNFENGKDIIKGHDIVIDALDNIEGKLTLQDICEELGIPFVHGAIAGWYGQVTTVFPGDKTL
KFLYKKEMRKGIEKELGNPSFTPALVASIQVSEALKVLIGRGEVLRRKVLFINTFEQEYEIIVL

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=152, Percent_Identity=30.2631578947368, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4885649, Length=152, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1787048, Length=231, Percent_Identity=29.4372294372294, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789177, Length=179, Percent_Identity=31.2849162011173, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI87082356, Length=156, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540406, Length=160, Percent_Identity=33.75, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193203301, Length=146, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=135, Percent_Identity=36.2962962962963, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322639, Length=166, Percent_Identity=27.1084337349398, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325323, Length=147, Percent_Identity=34.6938775510204, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320598, Length=174, Percent_Identity=25.8620689655172, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24582879, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573937, Length=163, Percent_Identity=31.9018404907975, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24660640, Length=136, Percent_Identity=33.0882352941176, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25212; Mature: 25081

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRYDRNMNMLSKEENEKLKDFRVCVLGCGGLGGYAIEMLGRLGIGYITAVDKDVFEETN
CCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
LNRQILSDMNSLGKSKALMAVERMKLVNPEVFVNAIVDEFNFENGKDIIKGHDIVIDALD
CCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC
NIEGKLTLQDICEELGIPFVHGAIAGWYGQVTTVFPGDKTLKFLYKKEMRKGIEKELGNP
CCCCEEEHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
SFTPALVASIQVSEALKVLIGRGEVLRRKVLFINTFEQEYEIIVL
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEC
>Mature Secondary Structure 
GRYDRNMNMLSKEENEKLKDFRVCVLGCGGLGGYAIEMLGRLGIGYITAVDKDVFEETN
CCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
LNRQILSDMNSLGKSKALMAVERMKLVNPEVFVNAIVDEFNFENGKDIIKGHDIVIDALD
CCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECC
NIEGKLTLQDICEELGIPFVHGAIAGWYGQVTTVFPGDKTLKFLYKKEMRKGIEKELGNP
CCCCEEEHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
SFTPALVASIQVSEALKVLIGRGEVLRRKVLFINTFEQEYEIIVL
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA