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The map label for this gene is fadH [C]

Identifier: 167040019

GI number: 167040019

Start: 1419046

End: 1420884

Strand: Direct

Name: fadH [C]

Synonym: Teth514_1378

Alternate gene names: 167040019

Gene position: 1419046-1420884 (Clockwise)

Preceding gene: 167040017

Following gene: 167040020

Centisome position: 57.75

GC content: 34.96

Gene sequence:

>1839_bases
ATGAAAGAGGTGATAAATATGCTATTGAAAGAAGGTAAAATAGGAAAGATTAAGTTAAAAAACAGACTAATTATGTTACC
GACTGTTACAAATTTATCAAACGAAGGCTTTGTAAGCGAAAGAGAAGTGGAATATTATAAAAGAAGGTCAAAAGGTGTTT
CATTGGTCATTGTAGGTGCGAGTTACGTAAACAAATTAGGAAAATTTTTCATAAATCAAATTGGAATAGATGACGATGAT
AAAATAGAAGGCCTTAAAAGATTATCGGAAGTCATACGTCAAAACGGTGCAAAAGCTGGTATTCAACTTGCAATGCACAA
TCCAAAATACAAACCTTCAGATTTTACAAAAGAGCAGCTTCAAGATTTTGTACAAAATTTTGTAGAGGCAGCAATAAGGG
CGGAAAAATCTGGTTTTGATGCTGTGGAGTTGCATTTTGCTCACGGATGGTTTGTAAATCAATTTTTATCTCCTGATACA
AACAAAAGGACTGACGAATACGGAGGAAATTTTGAAGGAAGGACAAAGTTTGCACTTGATATATTGCGAGAAGTTAAAAA
AACTATTCCGGAGATGACGGTAATTTGCAGGATTAATGGCAGTGATTTTACAGATAGAGGCTTTACAATTGAAGAGAGTG
TAAGATTCGCAAAACTGTTAGAATACCATGGTGCTGATGCTTTAGATATATCCTCAGGTGTATCTTCCACATCGGAGTAC
CATATCTCTCCTATGGGAATTGGAGATAAGCCTTTGATTGGAATTGTAAAGAGGATAAAAGAAAATGTAACTATACCTGT
TATAGCGATTGATAAGCTCGGCAGTGTTTATGATTGGGAAAAAGTTTTAGAGGATGGCATAGCTGATTTTATAGGGATAG
CTCGTGGTTTCATAGGAGATCCGGATTTGGCGGAAAAATTGATAAAAGGACACGAAGAAGATATAAGGTATTGCATTCAC
TGCAATCAGGCGTGTATTGCATACATTCAAAAAGGACTTTCTGTTTCTTGCATGATTAATCCAGAGGTAGGAAGAGAAAA
AGAATTTGAAGTAAAGACCGATAAACCATTAAATATAGCTGTAATTGGCGGCGGGCCAGCGGGCATGTCTGCGGCCAAAT
ATCTCGCAAAAAAAGGCCATAACGTTACTTTGTTTGAAAAAGAAAATAAACTTGGTGGACAACTAAATGTAGCAAAAGTG
CCTCCTCATAAACAAGAGATAGGAAAAGTTATTGAATATCTGGAAAATGATTTAAAGAAATACAATGTCAAAGTACATTT
AAATAAAAAAATAAGTTTACAGGAAATAAAAGAAATGCCTTATGATAAAATTGTCATTGCTACAGGCTCAAAGCCAGCTA
AAATCAATTTGGATGCGGATATAAATCCCTACATGGCTATTGAAGTATTGGAGGGAAATATTCCAAAAGGAAGAGATATT
GCAATAATTGGTGGAGGCCTTACTGGACTTGAAACAGCCGAATACCTTGCTGAAAAAGGGAAAAAAGTGACAGTTTTAGA
AATGAAAGAAGAAGTTGGCGAAGGGATATACCCAATGGTTAAAAAACTGATTTTAAATAGATTAAAAGAACTTAAAGTTG
ATATAATCACAAATGCTTTAATAAAAGAAATATCTGGGGGGAAACTCATGTATACTTCCAAGGACACATATAAAGTAGTC
AAAGTGGAGGATGTAGTTTTAGCAGTTGGAAATTTACCTGATACTGAATTTGAGGAACTAAAAAATGAGAACAGATATTA
TTTCATTGGTGACTGCAAAACTGTTGCTTCTGCAGTAGAAGCGATAAGGGATGGAGCAGAGCTTTCACTCATTATATAG

Upstream 100 bases:

>100_bases
TTGGCGTAAGTTCACATTATCACCTCATAAGTTTGTACTTATGGGTATTATAAAATTATACTATTTTACTTATAATGATA
CAAGAGGTACAATATTAATT

Downstream 100 bases:

>100_bases
AGGGAGGATATGAGGTTTATTAAGCTTACCCATTTAATGGTTAGATAAGTAAGAAATGGTAATATAAGCCATGAGATGCT
CTTGTTGTGATGAGAAAATT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MKEVINMLLKEGKIGKIKLKNRLIMLPTVTNLSNEGFVSEREVEYYKRRSKGVSLVIVGASYVNKLGKFFINQIGIDDDD
KIEGLKRLSEVIRQNGAKAGIQLAMHNPKYKPSDFTKEQLQDFVQNFVEAAIRAEKSGFDAVELHFAHGWFVNQFLSPDT
NKRTDEYGGNFEGRTKFALDILREVKKTIPEMTVICRINGSDFTDRGFTIEESVRFAKLLEYHGADALDISSGVSSTSEY
HISPMGIGDKPLIGIVKRIKENVTIPVIAIDKLGSVYDWEKVLEDGIADFIGIARGFIGDPDLAEKLIKGHEEDIRYCIH
CNQACIAYIQKGLSVSCMINPEVGREKEFEVKTDKPLNIAVIGGGPAGMSAAKYLAKKGHNVTLFEKENKLGGQLNVAKV
PPHKQEIGKVIEYLENDLKKYNVKVHLNKKISLQEIKEMPYDKIVIATGSKPAKINLDADINPYMAIEVLEGNIPKGRDI
AIIGGGLTGLETAEYLAEKGKKVTVLEMKEEVGEGIYPMVKKLILNRLKELKVDIITNALIKEISGGKLMYTSKDTYKVV
KVEDVVLAVGNLPDTEFEELKNENRYYFIGDCKTVASAVEAIRDGAELSLII

Sequences:

>Translated_612_residues
MKEVINMLLKEGKIGKIKLKNRLIMLPTVTNLSNEGFVSEREVEYYKRRSKGVSLVIVGASYVNKLGKFFINQIGIDDDD
KIEGLKRLSEVIRQNGAKAGIQLAMHNPKYKPSDFTKEQLQDFVQNFVEAAIRAEKSGFDAVELHFAHGWFVNQFLSPDT
NKRTDEYGGNFEGRTKFALDILREVKKTIPEMTVICRINGSDFTDRGFTIEESVRFAKLLEYHGADALDISSGVSSTSEY
HISPMGIGDKPLIGIVKRIKENVTIPVIAIDKLGSVYDWEKVLEDGIADFIGIARGFIGDPDLAEKLIKGHEEDIRYCIH
CNQACIAYIQKGLSVSCMINPEVGREKEFEVKTDKPLNIAVIGGGPAGMSAAKYLAKKGHNVTLFEKENKLGGQLNVAKV
PPHKQEIGKVIEYLENDLKKYNVKVHLNKKISLQEIKEMPYDKIVIATGSKPAKINLDADINPYMAIEVLEGNIPKGRDI
AIIGGGLTGLETAEYLAEKGKKVTVLEMKEEVGEGIYPMVKKLILNRLKELKVDIITNALIKEISGGKLMYTSKDTYKVV
KVEDVVLAVGNLPDTEFEELKNENRYYFIGDCKTVASAVEAIRDGAELSLII
>Mature_612_residues
MKEVINMLLKEGKIGKIKLKNRLIMLPTVTNLSNEGFVSEREVEYYKRRSKGVSLVIVGASYVNKLGKFFINQIGIDDDD
KIEGLKRLSEVIRQNGAKAGIQLAMHNPKYKPSDFTKEQLQDFVQNFVEAAIRAEKSGFDAVELHFAHGWFVNQFLSPDT
NKRTDEYGGNFEGRTKFALDILREVKKTIPEMTVICRINGSDFTDRGFTIEESVRFAKLLEYHGADALDISSGVSSTSEY
HISPMGIGDKPLIGIVKRIKENVTIPVIAIDKLGSVYDWEKVLEDGIADFIGIARGFIGDPDLAEKLIKGHEEDIRYCIH
CNQACIAYIQKGLSVSCMINPEVGREKEFEVKTDKPLNIAVIGGGPAGMSAAKYLAKKGHNVTLFEKENKLGGQLNVAKV
PPHKQEIGKVIEYLENDLKKYNVKVHLNKKISLQEIKEMPYDKIVIATGSKPAKINLDADINPYMAIEVLEGNIPKGRDI
AIIGGGLTGLETAEYLAEKGKKVTVLEMKEEVGEGIYPMVKKLILNRLKELKVDIITNALIKEISGGKLMYTSKDTYKVV
KVEDVVLAVGNLPDTEFEELKNENRYYFIGDCKTVASAVEAIRDGAELSLII

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=665, Percent_Identity=25.5639097744361, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1787939, Length=347, Percent_Identity=24.4956772334294, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17559802, Length=207, Percent_Identity=30.9178743961353, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17565138, Length=267, Percent_Identity=26.2172284644195, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17540738, Length=210, Percent_Identity=30, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17564188, Length=208, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI72001454, Length=126, Percent_Identity=38.0952380952381, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17566914, Length=211, Percent_Identity=30.3317535545024, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559804, Length=128, Percent_Identity=35.15625, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321973, Length=233, Percent_Identity=27.0386266094421, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325086, Length=230, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574881, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24665539, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24665547, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24665543, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 68110; Mature: 68110

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVINMLLKEGKIGKIKLKNRLIMLPTVTNLSNEGFVSEREVEYYKRRSKGVSLVIVGA
CHHHHHHHHHCCCCCEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECH
SYVNKLGKFFINQIGIDDDDKIEGLKRLSEVIRQNGAKAGIQLAMHNPKYKPSDFTKEQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHH
QDFVQNFVEAAIRAEKSGFDAVELHFAHGWFVNQFLSPDTNKRTDEYGGNFEGRTKFALD
HHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHH
ILREVKKTIPEMTVICRINGSDFTDRGFTIEESVRFAKLLEYHGADALDISSGVSSTSEY
HHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCE
HISPMGIGDKPLIGIVKRIKENVTIPVIAIDKLGSVYDWEKVLEDGIADFIGIARGFIGD
EEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PDLAEKLIKGHEEDIRYCIHCNQACIAYIQKGLSVSCMINPEVGREKEFEVKTDKPLNIA
HHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCEEEE
VIGGGPAGMSAAKYLAKKGHNVTLFEKENKLGGQLNVAKVPPHKQEIGKVIEYLENDLKK
EECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
YNVKVHLNKKISLQEIKEMPYDKIVIATGSKPAKINLDADINPYMAIEVLEGNIPKGRDI
EEEEEEECCCCCHHHHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCCCEE
AIIGGGLTGLETAEYLAEKGKKVTVLEMKEEVGEGIYPMVKKLILNRLKELKVDIITNAL
EEEECCCCHHHHHHHHHHCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKEISGGKLMYTSKDTYKVVKVEDVVLAVGNLPDTEFEELKNENRYYFIGDCKTVASAVE
HHHCCCCEEEEECCCCEEEEEEEEEEEEECCCCCHHHHHHHCCCCEEEEECHHHHHHHHH
AIRDGAELSLII
HHHCCCCEEEEC
>Mature Secondary Structure
MKEVINMLLKEGKIGKIKLKNRLIMLPTVTNLSNEGFVSEREVEYYKRRSKGVSLVIVGA
CHHHHHHHHHCCCCCEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECH
SYVNKLGKFFINQIGIDDDDKIEGLKRLSEVIRQNGAKAGIQLAMHNPKYKPSDFTKEQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHH
QDFVQNFVEAAIRAEKSGFDAVELHFAHGWFVNQFLSPDTNKRTDEYGGNFEGRTKFALD
HHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHH
ILREVKKTIPEMTVICRINGSDFTDRGFTIEESVRFAKLLEYHGADALDISSGVSSTSEY
HHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCE
HISPMGIGDKPLIGIVKRIKENVTIPVIAIDKLGSVYDWEKVLEDGIADFIGIARGFIGD
EEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PDLAEKLIKGHEEDIRYCIHCNQACIAYIQKGLSVSCMINPEVGREKEFEVKTDKPLNIA
HHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCEEEE
VIGGGPAGMSAAKYLAKKGHNVTLFEKENKLGGQLNVAKVPPHKQEIGKVIEYLENDLKK
EECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
YNVKVHLNKKISLQEIKEMPYDKIVIATGSKPAKINLDADINPYMAIEVLEGNIPKGRDI
EEEEEEECCCCCHHHHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCCCCCEE
AIIGGGLTGLETAEYLAEKGKKVTVLEMKEEVGEGIYPMVKKLILNRLKELKVDIITNAL
EEEECCCCHHHHHHHHHHCCCEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IKEISGGKLMYTSKDTYKVVKVEDVVLAVGNLPDTEFEELKNENRYYFIGDCKTVASAVE
HHHCCCCEEEEECCCCEEEEEEEEEEEEECCCCCHHHHHHHCCCCEEEEECHHHHHHHHH
AIRDGAELSLII
HHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]