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The map label for this gene is era

Identifier: 167039985

GI number: 167039985

Start: 1380678

End: 1381586

Strand: Direct

Name: era

Synonym: Teth514_1344

Alternate gene names: 167039985

Gene position: 1380678-1381586 (Clockwise)

Preceding gene: 167039984

Following gene: 167039986

Centisome position: 56.19

GC content: 33.11

Gene sequence:

>909_bases
ATGGGCCATAAAGCTGGTTTTGTAGCATTAGTTGGTAGAACTAATGTAGGTAAATCTACTCTTTTAAATGCAATTTTACA
AGAGAAGATTGCTATTACTTCTCCCAAACCCCAAACTACTCGAAATACCATTCGTGGGATTTTGACAACAGATGAATACC
AGGTTATTTTTGTTGACACTCCTGGCATTCATAAACCTAAATCTAAATTAAGCGAATTTATGATTGAGGTAGCTAAAAGA
ACATTGAAGGAAGTTGACCTTATTTTGTATATGATAGAACCAGATACGGAAGTAGGACCTGGAGATAGATACATAATCGA
ACATTTAAAAGAAGTAGATACACCTGTCATACTTGTAGTCAACAAAATAGATTTGGTGCCTGAGAAAAGAGTAGAAGAGA
CTATAAAAATTTTTAAAGAGCAATATGAGTTTAAAGATGTAGTAGCTATTTCTGCTATTGAAAATAAAAATATAGATTTG
TTAAAAGAAAAAATTGTATCACTTTTGCCAGAAGGCCCCAAATATTATTTGGATGATTATATAACAGATCAGCCCGAAAA
ATTAATAGTGGCAGAAATAATTCGAGAGAAGATGTTACACTTTTTAGAGGAAGAAGTACCTCACGGTGTTTATGTGGAAG
TAGAATCTATTAAAGAGAGGGAAGATAAAGATATAATAGACATTGAAGCATATATTTACTGTGAGAAAGAGTCCCACAAA
GGAATTATTATAGGCAAAAATGGGCAAATGCTAAAAAAGATAGGTCAAAGTGCGCGACTTGATTTAGAAGAATTTTATGG
AAAACAGGTTTTTCTTGACCTATGGGTAAAGACGAGGAAGGGGTGGAGAGACAATACAACGTTACTTAAAAAATTAGGAT
ATGCCATTGACAAGAAAACTTACGAATAG

Upstream 100 bases:

>100_bases
AAGGTAAAATCCACTCTTTTTCTCAGGTATTTTTTGGAGGTTTATTTGGGATATTGATTACAGTGTTGATTTTTCAAATA
ATCAAATAAGGAGTGATGAT

Downstream 100 bases:

>100_bases
TAAAGTATTTAGTGAAAACAAAAGGAGGTTATGTCATGAACATAGCAAAAATGATTGACCACACTCTACTGAAGCCAAAT
GCGACAAAAAGTGAAATAGA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MGHKAGFVALVGRTNVGKSTLLNAILQEKIAITSPKPQTTRNTIRGILTTDEYQVIFVDTPGIHKPKSKLSEFMIEVAKR
TLKEVDLILYMIEPDTEVGPGDRYIIEHLKEVDTPVILVVNKIDLVPEKRVEETIKIFKEQYEFKDVVAISAIENKNIDL
LKEKIVSLLPEGPKYYLDDYITDQPEKLIVAEIIREKMLHFLEEEVPHGVYVEVESIKEREDKDIIDIEAYIYCEKESHK
GIIIGKNGQMLKKIGQSARLDLEEFYGKQVFLDLWVKTRKGWRDNTTLLKKLGYAIDKKTYE

Sequences:

>Translated_302_residues
MGHKAGFVALVGRTNVGKSTLLNAILQEKIAITSPKPQTTRNTIRGILTTDEYQVIFVDTPGIHKPKSKLSEFMIEVAKR
TLKEVDLILYMIEPDTEVGPGDRYIIEHLKEVDTPVILVVNKIDLVPEKRVEETIKIFKEQYEFKDVVAISAIENKNIDL
LKEKIVSLLPEGPKYYLDDYITDQPEKLIVAEIIREKMLHFLEEEVPHGVYVEVESIKEREDKDIIDIEAYIYCEKESHK
GIIIGKNGQMLKKIGQSARLDLEEFYGKQVFLDLWVKTRKGWRDNTTLLKKLGYAIDKKTYE
>Mature_301_residues
GHKAGFVALVGRTNVGKSTLLNAILQEKIAITSPKPQTTRNTIRGILTTDEYQVIFVDTPGIHKPKSKLSEFMIEVAKRT
LKEVDLILYMIEPDTEVGPGDRYIIEHLKEVDTPVILVVNKIDLVPEKRVEETIKIFKEQYEFKDVVAISAIENKNIDLL
KEKIVSLLPEGPKYYLDDYITDQPEKLIVAEIIREKMLHFLEEEVPHGVYVEVESIKEREDKDIIDIEAYIYCEKESHKG
IIIGKNGQMLKKIGQSARLDLEEFYGKQVFLDLWVKTRKGWRDNTTLLKKLGYAIDKKTYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=26.6871165644172, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788919, Length=295, Percent_Identity=41.6949152542373, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87082120, Length=125, Percent_Identity=35.2, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323665, Length=208, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646434, Length=307, Percent_Identity=25.4071661237785, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_THEP3 (B0KA54)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665353.1
- ProteinModelPortal:   B0KA54
- SMR:   B0KA54
- GeneID:   5875025
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1365
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   TPSE340099:TETH39_1365-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34777; Mature: 34646

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHKAGFVALVGRTNVGKSTLLNAILQEKIAITSPKPQTTRNTIRGILTTDEYQVIFVDT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEECCCEEEEEEEC
PGIHKPKSKLSEFMIEVAKRTLKEVDLILYMIEPDTEVGPGDRYIIEHLKEVDTPVILVV
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEE
NKIDLVPEKRVEETIKIFKEQYEFKDVVAISAIENKNIDLLKEKIVSLLPEGPKYYLDDY
ECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHH
ITDQPEKLIVAEIIREKMLHFLEEEVPHGVYVEVESIKEREDKDIIDIEAYIYCEKESHK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEEEEEEECCCCC
GIIIGKNGQMLKKIGQSARLDLEEFYGKQVFLDLWVKTRKGWRDNTTLLKKLGYAIDKKT
EEEEECCCHHHHHCCHHHCCCHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
YE
CC
>Mature Secondary Structure 
GHKAGFVALVGRTNVGKSTLLNAILQEKIAITSPKPQTTRNTIRGILTTDEYQVIFVDT
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEECCCEEEEEEEC
PGIHKPKSKLSEFMIEVAKRTLKEVDLILYMIEPDTEVGPGDRYIIEHLKEVDTPVILVV
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEE
NKIDLVPEKRVEETIKIFKEQYEFKDVVAISAIENKNIDLLKEKIVSLLPEGPKYYLDDY
ECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHH
ITDQPEKLIVAEIIREKMLHFLEEEVPHGVYVEVESIKEREDKDIIDIEAYIYCEKESHK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEEEEEEECCCCC
GIIIGKNGQMLKKIGQSARLDLEEFYGKQVFLDLWVKTRKGWRDNTTLLKKLGYAIDKKT
EEEEECCCHHHHHCCHHHCCCHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
YE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA