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The map label for this gene is ygcA [C]

Identifier: 167039861

GI number: 167039861

Start: 1256464

End: 1257822

Strand: Direct

Name: ygcA [C]

Synonym: Teth514_1216

Alternate gene names: 167039861

Gene position: 1256464-1257822 (Clockwise)

Preceding gene: 167039857

Following gene: 167039868

Centisome position: 51.13

GC content: 33.19

Gene sequence:

>1359_bases
GTGAAAAGAAATGATATTATAACAGTTGAGATAAAAGACATGGAATTTGGTGGATTTGGGATAGGCTATTTTGAGGGGAA
AAAAGTAAAAATAAAAGGAGCACTTTTGGGGCAAATAATAAAGGCAAAAGTTAAAAAAGTAAAAAAGGATATGGTAGAAG
GCGAAATAGTGGAAGTAATGGAGAATTCTCCTTTGGAGAAGCAAAGCTTTTGCCCTCACTTTGGAGATTGTGGTGGTTGT
ATTTATCAAAATGTTGATTATTCAGATCAACTTAAGATAAAAGAAGATATTGTAAAGAAGCTTCTTGAAAAAGAGGGAAT
AAGAGATTATGAATTTTTAAGGATTGTGAAAAGTCCTAAAGAGCATGGTTATAGGAATAAAATGGAATATACTTTTGGAA
AAGATAAAGAAGGTAATGAGGTGTTAGGACTTCATAGAAAAGGTAGATTTTATGAAGTGGTTATGACAGATAAGTGTAAT
ATTGTTGATGATGACTTTCTAAAAGCTTTAAATCTCACTTTTGATTATGCAATAAAAAAAGGACTACCTTTTTATGATAA
AAAAACTCATAAGGGTTTTTTGAGACATTTGGTGGTTCGGAAAGCTTCAAAAGCAGGGGAAATTTTGTTAAATATTGTAA
CAACAACACAGTTGGAACATGACTTTAAAGAGCTTATTGAGATATATAAAAATGTGGATTTTGAAAGTCGGCTTGTAGGT
GTACTACATACTCAAAACGATTCCTGGTCAGATGCTGTAGTATGTGAAAAGTTAAATGTGTTATATGGAAAAGATTATCT
TATTGAAGAGCTTTTAGGATTAAAATTTAAAATAAGTGCATTTTCTTTTTTTCAGACCAATTCATACGGGGCAGAAAAAC
TTTATGAGACGGTGAGGGAATTTGCAGGAGATGTATCTGACAAAATAGTTTTTGATTTGTACTCCGGTACAGGGACCATA
GGTATAATTATGGCTCCAATGGCTAAAAAAGTGATTGGGATAGAACTTGTGGAAGAAGCAGTTATGTCGGCGAGGGAAAA
CGCAGAACTCAATGGACTTAAAAATTGCACTTTCATTGCCGGTGATGTCTCAAAGAAACTCAAAGAAATTAAAGAAATGC
CTGATGTGGTGATTGTGGATCCTCCAAGGTCTGGAATCAATCCAAAAGCTCTTGAAGATATTATAAAATTCAACCCTCAA
AAAGTAGTTTATGTTTCTTGTAATCCTGAATCTCTTGCAAGAGATTTAAAAATTTTTAGTGAAGGAGGATATAAAGTAGA
TAAAGTAAAATGTGTAGACATGTTTCCTCATACCTATCACGTGGAGTGCGTAGTATTGATGTCAAGGGTTGAGAAGTAG

Upstream 100 bases:

>100_bases
GTAAAGGTTATTTTATTTTTTGATAAAAACATTTTAGTGAATTATATTAGAATTATTGAGAAAAAAGAGGTATAATCTAA
ATAGCGAAGGAGGAATGAGA

Downstream 100 bases:

>100_bases
CTCTACTAAAAATACTGATAAATAAAGGGTTTCCAGACATTAGGTTTTTCTCACGGTTACTTTGCCGGAAGAAATAATGT
CAGAAAACCCTTATTTTTAT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKRNDIITVEIKDMEFGGFGIGYFEGKKVKIKGALLGQIIKAKVKKVKKDMVEGEIVEVMENSPLEKQSFCPHFGDCGGC
IYQNVDYSDQLKIKEDIVKKLLEKEGIRDYEFLRIVKSPKEHGYRNKMEYTFGKDKEGNEVLGLHRKGRFYEVVMTDKCN
IVDDDFLKALNLTFDYAIKKGLPFYDKKTHKGFLRHLVVRKASKAGEILLNIVTTTQLEHDFKELIEIYKNVDFESRLVG
VLHTQNDSWSDAVVCEKLNVLYGKDYLIEELLGLKFKISAFSFFQTNSYGAEKLYETVREFAGDVSDKIVFDLYSGTGTI
GIIMAPMAKKVIGIELVEEAVMSARENAELNGLKNCTFIAGDVSKKLKEIKEMPDVVIVDPPRSGINPKALEDIIKFNPQ
KVVYVSCNPESLARDLKIFSEGGYKVDKVKCVDMFPHTYHVECVVLMSRVEK

Sequences:

>Translated_452_residues
MKRNDIITVEIKDMEFGGFGIGYFEGKKVKIKGALLGQIIKAKVKKVKKDMVEGEIVEVMENSPLEKQSFCPHFGDCGGC
IYQNVDYSDQLKIKEDIVKKLLEKEGIRDYEFLRIVKSPKEHGYRNKMEYTFGKDKEGNEVLGLHRKGRFYEVVMTDKCN
IVDDDFLKALNLTFDYAIKKGLPFYDKKTHKGFLRHLVVRKASKAGEILLNIVTTTQLEHDFKELIEIYKNVDFESRLVG
VLHTQNDSWSDAVVCEKLNVLYGKDYLIEELLGLKFKISAFSFFQTNSYGAEKLYETVREFAGDVSDKIVFDLYSGTGTI
GIIMAPMAKKVIGIELVEEAVMSARENAELNGLKNCTFIAGDVSKKLKEIKEMPDVVIVDPPRSGINPKALEDIIKFNPQ
KVVYVSCNPESLARDLKIFSEGGYKVDKVKCVDMFPHTYHVECVVLMSRVEK
>Mature_452_residues
MKRNDIITVEIKDMEFGGFGIGYFEGKKVKIKGALLGQIIKAKVKKVKKDMVEGEIVEVMENSPLEKQSFCPHFGDCGGC
IYQNVDYSDQLKIKEDIVKKLLEKEGIRDYEFLRIVKSPKEHGYRNKMEYTFGKDKEGNEVLGLHRKGRFYEVVMTDKCN
IVDDDFLKALNLTFDYAIKKGLPFYDKKTHKGFLRHLVVRKASKAGEILLNIVTTTQLEHDFKELIEIYKNVDFESRLVG
VLHTQNDSWSDAVVCEKLNVLYGKDYLIEELLGLKFKISAFSFFQTNSYGAEKLYETVREFAGDVSDKIVFDLYSGTGTI
GIIMAPMAKKVIGIELVEEAVMSARENAELNGLKNCTFIAGDVSKKLKEIKEMPDVVIVDPPRSGINPKALEDIIKFNPQ
KVVYVSCNPESLARDLKIFSEGGYKVDKVKCVDMFPHTYHVECVVLMSRVEK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI269784680, Length=434, Percent_Identity=28.8018433179723, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI269784676, Length=434, Percent_Identity=28.8018433179723, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI20149688, Length=434, Percent_Identity=28.8018433179723, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI34222389, Length=419, Percent_Identity=30.0715990453461, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI51173878, Length=419, Percent_Identity=30.0715990453461, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI269784678, Length=381, Percent_Identity=29.6587926509186, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1789148, Length=453, Percent_Identity=28.0353200883002, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1787083, Length=377, Percent_Identity=26.2599469496021, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1790403, Length=243, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71997438, Length=221, Percent_Identity=29.8642533936652, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322909, Length=394, Percent_Identity=24.8730964467005, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666579, Length=462, Percent_Identity=27.7056277056277, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51411; Mature: 51411

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNDIITVEIKDMEFGGFGIGYFEGKKVKIKGALLGQIIKAKVKKVKKDMVEGEIVEVM
CCCCCEEEEEEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ENSPLEKQSFCPHFGDCGGCIYQNVDYSDQLKIKEDIVKKLLEKEGIRDYEFLRIVKSPK
CCCCCCHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCHH
EHGYRNKMEYTFGKDKEGNEVLGLHRKGRFYEVVMTDKCNIVDDDFLKALNLTFDYAIKK
HCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GLPFYDKKTHKGFLRHLVVRKASKAGEILLNIVTTTQLEHDFKELIEIYKNVDFESRLVG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHEEE
VLHTQNDSWSDAVVCEKLNVLYGKDYLIEELLGLKFKISAFSFFQTNSYGAEKLYETVRE
EEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEEEEEECCCCCHHHHHHHHHH
FAGDVSDKIVFDLYSGTGTIGIIMAPMAKKVIGIELVEEAVMSARENAELNGLKNCTFIA
HHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GDVSKKLKEIKEMPDVVIVDPPRSGINPKALEDIIKFNPQKVVYVSCNPESLARDLKIFS
CHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHC
EGGYKVDKVKCVDMFPHTYHVECVVLMSRVEK
CCCCEEEEEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRNDIITVEIKDMEFGGFGIGYFEGKKVKIKGALLGQIIKAKVKKVKKDMVEGEIVEVM
CCCCCEEEEEEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ENSPLEKQSFCPHFGDCGGCIYQNVDYSDQLKIKEDIVKKLLEKEGIRDYEFLRIVKSPK
CCCCCCHHHCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCHH
EHGYRNKMEYTFGKDKEGNEVLGLHRKGRFYEVVMTDKCNIVDDDFLKALNLTFDYAIKK
HCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GLPFYDKKTHKGFLRHLVVRKASKAGEILLNIVTTTQLEHDFKELIEIYKNVDFESRLVG
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHEEE
VLHTQNDSWSDAVVCEKLNVLYGKDYLIEELLGLKFKISAFSFFQTNSYGAEKLYETVRE
EEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEEEEEECCCCCHHHHHHHHHH
FAGDVSDKIVFDLYSGTGTIGIIMAPMAKKVIGIELVEEAVMSARENAELNGLKNCTFIA
HHCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
GDVSKKLKEIKEMPDVVIVDPPRSGINPKALEDIIKFNPQKVVYVSCNPESLARDLKIFS
CHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHC
EGGYKVDKVKCVDMFPHTYHVECVVLMSRVEK
CCCCEEEEEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]