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The map label for this gene is norM [H]

Identifier: 167039844

GI number: 167039844

Start: 1237795

End: 1239147

Strand: Reverse

Name: norM [H]

Synonym: Teth514_1199

Alternate gene names: 167039844

Gene position: 1239147-1237795 (Counterclockwise)

Preceding gene: 167039851

Following gene: 167039811

Centisome position: 50.43

GC content: 32.96

Gene sequence:

>1353_bases
ATGGCAACTAAAAAAGAAATAAAAGAAATACTTAATTTAGCATTACCTGCAGTTGGAGAAATGCTTTTATACATGGTTGT
GTGGGTAATAGATACGATGATGGTGGGGCAATTTGGCGGTAAAGACAGTGTTAGTGCTGTAGGCCTTGCATCAGAAATTA
TATATACCTTCTCTAACATTTTTGTAGCAATGGGAATCTCTATAGGAGTAACTTCCTATGTCGCCCGTAGCATTGGAGCA
AAAGATTTTGAAACTGCTGAAAAATACGCATCTCAAGGAATTTTTTTAGGATTTATTGTTGCTTTATTTATTTCTTTAAT
ACTTGTTGCTTTTGCAGAAAATTTTTTAATAATAGCCAGTGCTACTGGTAATGTACTTTTCTTAGGAAAAATATATATAA
AAATTGCATCAATAGGTATTTTCTTTAATATGCTTATGAATGTATTAAACGCAGTTTTAAGAGCACAAGGAAATACAAAA
ACCCCCATGATAGCAGCAAGTATAGTTATATTTATCAACATTTTATTGGATTGGATTTTAATATTTGGAAAATTAGGCTT
TCCTGCTTTAGGTGCAAAAGGTTCTGCAATTGCTACTACTATAGCACAAATTACTGGCTTTATATTTATAATGTCATATT
ACTTCAGCCAAAAAATATTAAATATTGAGCTTCATGATATAGTAAACTTTGATAAACAAATAATTGTAAATATACTAAAA
CTTGCTTTTCCTGCTTCTCTTCAAGAAGCTGCCTTTGACATAAGTCGACTTATTTCAATATTCATGATAATGCACCTTGG
AACTGTAGCTTTTGCAGCGAATCAAATTGCAACTACGATTGAATCTATCTCCTTTATGCCAGGATGGGGTTTTGCAGTGG
CTGCAACCACAATGGCAGGTCAAATGGTTGGCGCAAAAGACTTTGAAAGTGCAAAAAGATATACAAATATTGCAGCATTA
TTCGCTGTAGCTATTATGGGTACAATGTCTATACTATTTCTTACAATACCTCATCTTTTTATGAGAGCTTTTATAAAAGA
TGCTGATGTAATTGCAGTAGGAATTCTCTGCCTTATGGTAGCCTCTATTGAACAACCTTTTATGGCAGTTGGCATGGTTT
ATGGAGGTGGCCTTAAAGGAAGTGGAAATACAAAGATTCCCTTTATTATCTCTACAATATCCAGCTGGTTTATAAGACTT
CCTCTTATGTACGTAGTCATCTACATTTTAAATTTAGGAGTTGTCTATGTATGGTTTGTAACAGCCATCCAATGGGCGTT
TGAAGGAAGCATAATGTATATATACTTTAGAAAAGAAATAGATAAATTAAAAAGGGGAGTAAGGAATATATAA

Upstream 100 bases:

>100_bases
TATTTGGACTCCATTATAATCCAATTGAAATTGCCCCTAAACAATACAGACAATATAGGATGTTTCCTTGTATTTTTGCA
ATAAAAATAGGAGGTGTTAT

Downstream 100 bases:

>100_bases
ACCTTACTCCCCTTTATTGCCATCTAAGCATTATATAAGTCATAAGTAAAATGCTTATAATAATTGAAGCGGTAATAAAA
ACAGAAGCCAACTTAGCATT

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MATKKEIKEILNLALPAVGEMLLYMVVWVIDTMMVGQFGGKDSVSAVGLASEIIYTFSNIFVAMGISIGVTSYVARSIGA
KDFETAEKYASQGIFLGFIVALFISLILVAFAENFLIIASATGNVLFLGKIYIKIASIGIFFNMLMNVLNAVLRAQGNTK
TPMIAASIVIFINILLDWILIFGKLGFPALGAKGSAIATTIAQITGFIFIMSYYFSQKILNIELHDIVNFDKQIIVNILK
LAFPASLQEAAFDISRLISIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKDFESAKRYTNIAAL
FAVAIMGTMSILFLTIPHLFMRAFIKDADVIAVGILCLMVASIEQPFMAVGMVYGGGLKGSGNTKIPFIISTISSWFIRL
PLMYVVIYILNLGVVYVWFVTAIQWAFEGSIMYIYFRKEIDKLKRGVRNI

Sequences:

>Translated_450_residues
MATKKEIKEILNLALPAVGEMLLYMVVWVIDTMMVGQFGGKDSVSAVGLASEIIYTFSNIFVAMGISIGVTSYVARSIGA
KDFETAEKYASQGIFLGFIVALFISLILVAFAENFLIIASATGNVLFLGKIYIKIASIGIFFNMLMNVLNAVLRAQGNTK
TPMIAASIVIFINILLDWILIFGKLGFPALGAKGSAIATTIAQITGFIFIMSYYFSQKILNIELHDIVNFDKQIIVNILK
LAFPASLQEAAFDISRLISIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKDFESAKRYTNIAAL
FAVAIMGTMSILFLTIPHLFMRAFIKDADVIAVGILCLMVASIEQPFMAVGMVYGGGLKGSGNTKIPFIISTISSWFIRL
PLMYVVIYILNLGVVYVWFVTAIQWAFEGSIMYIYFRKEIDKLKRGVRNI
>Mature_449_residues
ATKKEIKEILNLALPAVGEMLLYMVVWVIDTMMVGQFGGKDSVSAVGLASEIIYTFSNIFVAMGISIGVTSYVARSIGAK
DFETAEKYASQGIFLGFIVALFISLILVAFAENFLIIASATGNVLFLGKIYIKIASIGIFFNMLMNVLNAVLRAQGNTKT
PMIAASIVIFINILLDWILIFGKLGFPALGAKGSAIATTIAQITGFIFIMSYYFSQKILNIELHDIVNFDKQIIVNILKL
AFPASLQEAAFDISRLISIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAGQMVGAKDFESAKRYTNIAALF
AVAIMGTMSILFLTIPHLFMRAFIKDADVIAVGILCLMVASIEQPFMAVGMVYGGGLKGSGNTKIPFIISTISSWFIRLP
LMYVVIYILNLGVVYVWFVTAIQWAFEGSIMYIYFRKEIDKLKRGVRNI

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=429, Percent_Identity=23.3100233100233, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI153792564, Length=412, Percent_Identity=23.0582524271845, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38261960, Length=237, Percent_Identity=27.0042194092827, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI226510954, Length=458, Percent_Identity=25.764192139738, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI48994890, Length=415, Percent_Identity=21.6867469879518, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49239; Mature: 49108

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKKEIKEILNLALPAVGEMLLYMVVWVIDTMMVGQFGGKDSVSAVGLASEIIYTFSNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FVAMGISIGVTSYVARSIGAKDFETAEKYASQGIFLGFIVALFISLILVAFAENFLIIAS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
ATGNVLFLGKIYIKIASIGIFFNMLMNVLNAVLRAQGNTKTPMIAASIVIFINILLDWIL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
IFGKLGFPALGAKGSAIATTIAQITGFIFIMSYYFSQKILNIELHDIVNFDKQIIVNILK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHCCHHHHHHHHHH
LAFPASLQEAAFDISRLISIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QMVGAKDFESAKRYTNIAALFAVAIMGTMSILFLTIPHLFMRAFIKDADVIAVGILCLMV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ASIEQPFMAVGMVYGGGLKGSGNTKIPFIISTISSWFIRLPLMYVVIYILNLGVVYVWFV
HHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIQWAFEGSIMYIYFRKEIDKLKRGVRNI
HHHHHHHCCCEEEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATKKEIKEILNLALPAVGEMLLYMVVWVIDTMMVGQFGGKDSVSAVGLASEIIYTFSNI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FVAMGISIGVTSYVARSIGAKDFETAEKYASQGIFLGFIVALFISLILVAFAENFLIIAS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
ATGNVLFLGKIYIKIASIGIFFNMLMNVLNAVLRAQGNTKTPMIAASIVIFINILLDWIL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
IFGKLGFPALGAKGSAIATTIAQITGFIFIMSYYFSQKILNIELHDIVNFDKQIIVNILK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHCCHHHHHHHHHH
LAFPASLQEAAFDISRLISIFMIMHLGTVAFAANQIATTIESISFMPGWGFAVAATTMAG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QMVGAKDFESAKRYTNIAALFAVAIMGTMSILFLTIPHLFMRAFIKDADVIAVGILCLMV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ASIEQPFMAVGMVYGGGLKGSGNTKIPFIISTISSWFIRLPLMYVVIYILNLGVVYVWFV
HHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIQWAFEGSIMYIYFRKEIDKLKRGVRNI
HHHHHHHCCCEEEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]