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The map label for this gene is cysK [H]

Identifier: 167039797

GI number: 167039797

Start: 1191317

End: 1192255

Strand: Direct

Name: cysK [H]

Synonym: Teth514_1150

Alternate gene names: 167039797

Gene position: 1191317-1192255 (Clockwise)

Preceding gene: 167039796

Following gene: 167039798

Centisome position: 48.48

GC content: 36.63

Gene sequence:

>939_bases
ATGCCTAAAAGACAAAACGAAATTTATGAGGATATAACTCAGCTTATAGGCAATACACCTATGATTAGGTTGAATAAAGT
TGTTCCTGAAAATTCAGCGGAGGTCATAGTAAAATTAGAGTCTTTTAACCCAGGTGGAAGTGTTAAGGACAGAATTGCAT
TAAATATGATAAAAAGAGCTGAGGAAGAAGGAAGATTAAAACCTGGTGGGACAATTGTTGAACCTACCAGTGGAAATACA
GGCATTGGTCTTGCGATGGTTAGTGCTGTAAAAGGGTATAAGTTGATTCTTGTAATGCCTGATACGATGAGTATAGAACG
ACGAAATTTACTTTTGTCATATGGAGCAGAGCTTGTTTTAACACCCGGTGCAGAGGGTATGAAAGGAGCCATAAAAAAGG
CACAAGAAATTTTGGAATTAAATCCTGGTTATATAATGTTAGATCAGTTTAAAAATCCTGCGAATCCAGAAATACATGAA
CTTACAACGGCAAAAGAAATATTAAAAGATACAAATGGAATAGTAGATGCATTTGTAGCAGGTGTAGGCACAGGGGGAAC
AATATCCGGAGTAGGGAAAGTTTTAAAGCAATATAACAAAGATATAAAAATTTTTGCAGTAGAACCAGAGGAATCTCCTG
TATTGTCAGGCGGCAAACCTGGACCTCATAAGATACAAGGAATAGGAGCTGGATTTATTCCCGACACATTAAATCTTGAC
GTTATCGATGAAATTATAAAGGTAAAAGAGAGAGATGCTTTTGAGATGTCAATGAAACTTGCAAAACAAGAAGGGATTCT
TTGTGGTATTTCTTCAGGCGCAAATGTTTTTGCGGCAGTTGAAGTTGCAAATCGCCTCGGGAAAGGAAAACGAGTTGTAA
CAGTACTACCTGATACTGGGGAAAGATATTTAAGTATGCACAAATTTTTTGAATATTGA

Upstream 100 bases:

>100_bases
AAATGCACCTATTGACATTGAGATAAGATTGTGATACCTTAAAAAGGGAAAATTTATAATTCTTATCGGAATACTCGGAA
TTAAAAGGAGGCAAAAAGTT

Downstream 100 bases:

>100_bases
ACGCCATAATGAATTTAATCCTAATGGAAGAATGACAGCACTTCGTTGTGGAGCAAATGTTGTAATGCCCAATGTGACAG
AGGGAGAATGCAGAAAGTTG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPKRQNEIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPGYIMLDQFKNPANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY

Sequences:

>Translated_312_residues
MPKRQNEIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNT
GIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPGYIMLDQFKNPANPEIHE
LTTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY
>Mature_311_residues
PKRQNEIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRAEEEGRLKPGGTIVEPTSGNTG
IGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVLTPGAEGMKGAIKKAQEILELNPGYIMLDQFKNPANPEIHEL
TTAKEILKDTNGIVDAFVAGVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLDV
IDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTGERYLSMHKFFEY

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=319, Percent_Identity=43.2601880877743, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI295821200, Length=319, Percent_Identity=43.2601880877743, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI4557415, Length=319, Percent_Identity=43.2601880877743, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=53.5031847133758, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=43.6666666666667, Blast_Score=250, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=52, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=53.1353135313531, Blast_Score=283, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=50.5050505050505, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=49.3377483443709, Blast_Score=281, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=48.0132450331126, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=50, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=38.4375, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=36.6459627329193, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=46.6101694915254, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=28.3536585365854, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17539800, Length=336, Percent_Identity=26.7857142857143, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=38.390092879257, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=35.7357357357357, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=42.3076923076923, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=42.3076923076923, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33733; Mature: 33602

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRQNEIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRA
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEPTSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPGYIMLDQFKNPANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC
>Mature Secondary Structure 
PKRQNEIYEDITQLIGNTPMIRLNKVVPENSAEVIVKLESFNPGGSVKDRIALNMIKRA
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
EEEGRLKPGGTIVEPTSGNTGIGLAMVSAVKGYKLILVMPDTMSIERRNLLLSYGAELVL
HHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEECCCEEEE
TPGAEGMKGAIKKAQEILELNPGYIMLDQFKNPANPEIHELTTAKEILKDTNGIVDAFVA
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
GVGTGGTISGVGKVLKQYNKDIKIFAVEPEESPVLSGGKPGPHKIQGIGAGFIPDTLNLD
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
VIDEIIKVKERDAFEMSMKLAKQEGILCGISSGANVFAAVEVANRLGKGKRVVTVLPDTG
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHCCCCCEEEEECCCCC
ERYLSMHKFFEY
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA