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The map label for this gene is glyA

Identifier: 167039658

GI number: 167039658

Start: 1037512

End: 1038753

Strand: Reverse

Name: glyA

Synonym: Teth514_1008

Alternate gene names: 167039658

Gene position: 1038753-1037512 (Counterclockwise)

Preceding gene: 167039659

Following gene: 167039648

Centisome position: 42.27

GC content: 38.57

Gene sequence:

>1242_bases
ATGGATATTGAAATAATAAGAAAAACTGATCCAGAAATCGCAGACGCAATTGAAAAGGAGCTTATAAGGCAGAGAAATAA
AATAGAGCTCATAGCTTCTGAAAATTTTGTAAGTAGAGCCGTAATGGAAGCAATGGGGTCCCCTCTTACTAATAAATACG
CAGAAGGGTATCCAAATAAAAGGTATTACGGCGGTTGCGAATATGTGGATATAGCTGAAGAATTAGCAAGAGAAAGGCTC
AAAAAACTTTTTGGTGCTGAACACGCAAATGTACAACCTCATTCAGGAGCACAGGCAAACATGGCTGCTTATTTTGCTCT
TATAAAGCCAGGAGATACTGTGCTGGGAATGGATTTAGCCCATGGAGGGCACCTCACTCATGGAAGCAAAGTCAATTTTT
CAGGCCAAATCTATAATTTCGTATCTTACGGAGTAAGAGAAGATACAGGATATATAGATTACGATGAAGTAGAAAGAGTC
GCAAAAAAGCACAAACCCAAATTGATTGTCGCAGGTGCTAGCGCTTACCCAAGGATAATCGATTTTAAGAGATTTAGAGA
AATTGCAGACAAGGTTGGAGCTTACCTAATGGTAGATATGGCTCATATAGCTGGTCTTGTAGCAGCAGGTCTTCATCCTA
ATCCTGTTCCTTATGCAGATGTCGTTACGACTACCACCCATAAGACTTTAAGAGGCCCAAGAGGAGGAGCTATTCTTTGC
AAAGAAGAATACGCAAAAGCAATAGACAAAGCACTCTTCCCGGGCACACAAGGTGGCCCTTTAATGCATATAATAGCAGC
AAAAGCCGTTTGTTTTAAAGAAGCTCTCACCGATGAATTCAAAGAATATCAAAAAAGAATTGTCGAAAATGCAAAAGCTT
TAGCAAATGCATTAATGGAAAGAGGAATAAATTTAGTGTCAGGTGGAACTGATAACCACTTGATGTTGTTGGATTTAAGA
AACACAGGAATAACAGGCAAAGAGTTAGAAACAAGATTAGATGAAGTAAACATAACTTGCAACAAAAATGCTATACCTTT
TGACCCATTAGGGCCAAATGTCACTTCTGGTGTGAGACTGGGAACTCCAGCTGTTACAACAAGAGGAATGAAACCCGAAG
ATATGGTAGAAATAGCGGACATTATAGTCAATGTAATAAGGGATGAAAACTATAAAGAAAAAGCAAAAGAAAGAGTAGCA
AATCTTCTCAAAAAATACCCTCTTTATGAGGACCTCATATAA

Upstream 100 bases:

>100_bases
TTGTTAATTGGCGTTATTTTCTTCAAAAAGAAGTGCTGTTGAATATAGTATACAAAAGATTTATAATAGAGGTAGATAAT
GAAACATAGGGGGTAAAGTC

Downstream 100 bases:

>100_bases
AGAAGATAGGGAAAGTCTTTTACTGACTTTCCCTATTTCTTTCTCTCTTTATGTTCTTCTTTAAATTCCTTTGGCTTATA
ATACCTTCTGCCAAGCTCAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNKRYYGGCEYVDIAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERV
AKKHKPKLIVAGASAYPRIIDFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVA
NLLKKYPLYEDLI

Sequences:

>Translated_413_residues
MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNKRYYGGCEYVDIAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERV
AKKHKPKLIVAGASAYPRIIDFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVA
NLLKKYPLYEDLI
>Mature_413_residues
MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNKRYYGGCEYVDIAEELARERL
KKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERV
AKKHKPKLIVAGASAYPRIIDFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
KEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLR
NTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVA
NLLKKYPLYEDLI

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=46.4019851116625, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=46.4019851116625, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=46.4019851116625, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=46.4019851116625, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI22547186, Length=408, Percent_Identity=47.3039215686275, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=45.1612903225806, Blast_Score=341, Evalue=6e-94,
Organism=Homo sapiens, GI22547189, Length=393, Percent_Identity=46.5648854961832, Blast_Score=318, Evalue=7e-87,
Organism=Escherichia coli, GI1788902, Length=410, Percent_Identity=60, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI25144732, Length=405, Percent_Identity=47.4074074074074, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=405, Percent_Identity=47.4074074074074, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=414, Percent_Identity=47.1014492753623, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323087, Length=422, Percent_Identity=45.7345971563981, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=48.4848484848485, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=48.4848484848485, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_THEP3 (B0K742)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664525.1
- ProteinModelPortal:   B0K742
- SMR:   B0K742
- GeneID:   5874021
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0524
- HOGENOM:   HBG301263
- OMA:   SINITAN
- ProtClustDB:   PRK00011
- BioCyc:   TPSE340099:TETH39_0524-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45661; Mature: 45661

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNK
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHCCCCCC
RYYGGCEYVDIAEELARERLKKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEC
HGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERVAKKHKPKLIVAGASAYPRII
CCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHH
DFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHCCCCCCEEEE
KEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALME
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGINLVSGGTDNHLMLLDLRNTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRL
CCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
GTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVANLLKKYPLYEDLI
CCCCHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNK
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHCCCCCC
RYYGGCEYVDIAEELARERLKKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEC
HGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERVAKKHKPKLIVAGASAYPRII
CCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHH
DFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHCCCCCCEEEE
KEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALME
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGINLVSGGTDNHLMLLDLRNTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRL
CCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
GTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVANLLKKYPLYEDLI
CCCCHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA