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The map label for this gene is nhaC [H]

Identifier: 167039624

GI number: 167039624

Start: 992027

End: 993391

Strand: Reverse

Name: nhaC [H]

Synonym: Teth514_0972

Alternate gene names: 167039624

Gene position: 993391-992027 (Counterclockwise)

Preceding gene: 167039625

Following gene: 167039622

Centisome position: 40.43

GC content: 32.6

Gene sequence:

>1365_bases
ATGGAAAACAAATTTGGAATCTCACTTATAACTTTTTTGTTGATTTTGGCCATAACCATGACAATGGTATTAGTTTTTCA
CCAACCTCCCTATATACCGCTTTTTATAAGCTATATAATAACCTTTGCTATTGTTTTGATAAACGGTTTTTCGCCTCAAG
AACTTGTCAATATGTCAATTGATGGATTTAAAAAAGGTATAAATGTGATGATTATACTCCTTTTGATAGGAGCCCTAGTT
GCCTTGTGGAAACAGAATGGAACGCTTCCGGCTCTTGTTTACTATGCCTCCCACTTTTTAAAACCACAAGGTTTTCTATT
ATTGTCTTTTATCACAACCTCTATTATCTCAATGATTTTAGGTACAGCTGTAGGAACCGCCAGTACTATTGGAATAGTAA
TAATGGGATTAGCCCATGGCTTTGGCTATCCTCTTCCAATAGTTGCTGGTGCAGTAATATCCGGTTCTTTTATAGGAGAT
AGGACCTCTCCCCTTGCAGGAAATGTCATTCTTCTGTCGGATATGGGAGAAATTGAGCAATACAATGTACTTAAATCTCT
TTTTAAAACTGCAATTCCTACTTATATATTAACTGGTTTATTGTACTATCTTTTAAGTCTTCACATTAATATTTCTTCGC
CCTACACTTTTGACAATCTTGCAGCTATAATTTTGAAAAATTATAAAATAAACTTCTTCTTGTTTTTAGCTCCTATAATG
ATTATAACCTTAGCTTTTTTTAGAATTCCTACAAAGATAAATCTTTCAATTGCTGTCCTTCTCTCCTACTTTGTCTCTTT
ACTAAATGGTTATAACCTTATAGATTCTTTAAAAGTCATTATGATGGGAAATGTATCTAATATTCCAGAATTTAAATCTT
TCTTTTCAGGAGGAGGTATGGTTTCAATTTTCCCAATGATAGGAGTAGTAACCTTTGCTACCGCTCTTTCTGGAATATTA
GAAGGGACAGGAATTATAAAAGCAGTTTTTAAAAAAGCTCAAAAAATTAAAAACCCTAAAATTGCCTATTTGGTCACAAT
GTTATTAAGCACTTTAATGGCAGTAATAACTTGCAATCAAGCCCTTTCTGTAATTTTACCTTCCCGCATAATGTTAGAAG
TGTTTAGAAATCTTAACGTAAAAAGTGATATGATGGTAAGAGCAATAGCAGATTCAGGCATGATACTTGCCGGCATAATA
CCCTGGAATTTAGCAGCAATGTTTCTTTCTGCAGTTTTAGGAGTAAAAGTCATTGATTACCTTCCCTATGCTTATTTAAA
TCTATTATTCCCTATATTATCAATACTTATCGTGTTTATAGAAAGTAATAAACAATATAGCAATGTTCTAATGGAAGAAT
TTTAA

Upstream 100 bases:

>100_bases
CCGATGCTTTGTTATAAAGTTAATCAAAAAAGCAAAAAATATAGAAATTCACGTAATACCTTATAAATAACTTCTTCATT
ACTAAAAGGAGCAGTGAAAA

Downstream 100 bases:

>100_bases
AAAAAGCAGGATTTTATTCCTGCTTTTTTATCGCATATTTTAAGTTTATATAATAAGGTAACCCTTCTGCCATAGGGACC
TTCACTTCTCCTTGTATAAG

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MENKFGISLITFLLILAITMTMVLVFHQPPYIPLFISYIITFAIVLINGFSPQELVNMSIDGFKKGINVMIILLLIGALV
ALWKQNGTLPALVYYASHFLKPQGFLLLSFITTSIISMILGTAVGTASTIGIVIMGLAHGFGYPLPIVAGAVISGSFIGD
RTSPLAGNVILLSDMGEIEQYNVLKSLFKTAIPTYILTGLLYYLLSLHINISSPYTFDNLAAIILKNYKINFFLFLAPIM
IITLAFFRIPTKINLSIAVLLSYFVSLLNGYNLIDSLKVIMMGNVSNIPEFKSFFSGGGMVSIFPMIGVVTFATALSGIL
EGTGIIKAVFKKAQKIKNPKIAYLVTMLLSTLMAVITCNQALSVILPSRIMLEVFRNLNVKSDMMVRAIADSGMILAGII
PWNLAAMFLSAVLGVKVIDYLPYAYLNLLFPILSILIVFIESNKQYSNVLMEEF

Sequences:

>Translated_454_residues
MENKFGISLITFLLILAITMTMVLVFHQPPYIPLFISYIITFAIVLINGFSPQELVNMSIDGFKKGINVMIILLLIGALV
ALWKQNGTLPALVYYASHFLKPQGFLLLSFITTSIISMILGTAVGTASTIGIVIMGLAHGFGYPLPIVAGAVISGSFIGD
RTSPLAGNVILLSDMGEIEQYNVLKSLFKTAIPTYILTGLLYYLLSLHINISSPYTFDNLAAIILKNYKINFFLFLAPIM
IITLAFFRIPTKINLSIAVLLSYFVSLLNGYNLIDSLKVIMMGNVSNIPEFKSFFSGGGMVSIFPMIGVVTFATALSGIL
EGTGIIKAVFKKAQKIKNPKIAYLVTMLLSTLMAVITCNQALSVILPSRIMLEVFRNLNVKSDMMVRAIADSGMILAGII
PWNLAAMFLSAVLGVKVIDYLPYAYLNLLFPILSILIVFIESNKQYSNVLMEEF
>Mature_454_residues
MENKFGISLITFLLILAITMTMVLVFHQPPYIPLFISYIITFAIVLINGFSPQELVNMSIDGFKKGINVMIILLLIGALV
ALWKQNGTLPALVYYASHFLKPQGFLLLSFITTSIISMILGTAVGTASTIGIVIMGLAHGFGYPLPIVAGAVISGSFIGD
RTSPLAGNVILLSDMGEIEQYNVLKSLFKTAIPTYILTGLLYYLLSLHINISSPYTFDNLAAIILKNYKINFFLFLAPIM
IITLAFFRIPTKINLSIAVLLSYFVSLLNGYNLIDSLKVIMMGNVSNIPEFKSFFSGGGMVSIFPMIGVVTFATALSGIL
EGTGIIKAVFKKAQKIKNPKIAYLVTMLLSTLMAVITCNQALSVILPSRIMLEVFRNLNVKSDMMVRAIADSGMILAGII
PWNLAAMFLSAVLGVKVIDYLPYAYLNLLFPILSILIVFIESNKQYSNVLMEEF

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 49761; Mature: 49761

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKFGISLITFLLILAITMTMVLVFHQPPYIPLFISYIITFAIVLINGFSPQELVNMSI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCH
DGFKKGINVMIILLLIGALVALWKQNGTLPALVYYASHFLKPQGFLLLSFITTSIISMIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GTAVGTASTIGIVIMGLAHGFGYPLPIVAGAVISGSFIGDRTSPLAGNVILLSDMGEIEQ
HHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHH
YNVLKSLFKTAIPTYILTGLLYYLLSLHINISSPYTFDNLAAIILKNYKINFFLFLAPIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
IITLAFFRIPTKINLSIAVLLSYFVSLLNGYNLIDSLKVIMMGNVSNIPEFKSFFSGGGM
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCH
VSIFPMIGVVTFATALSGILEGTGIIKAVFKKAQKIKNPKIAYLVTMLLSTLMAVITCNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ALSVILPSRIMLEVFRNLNVKSDMMVRAIADSGMILAGIIPWNLAAMFLSAVLGVKVIDY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LPYAYLNLLFPILSILIVFIESNKQYSNVLMEEF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MENKFGISLITFLLILAITMTMVLVFHQPPYIPLFISYIITFAIVLINGFSPQELVNMSI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCH
DGFKKGINVMIILLLIGALVALWKQNGTLPALVYYASHFLKPQGFLLLSFITTSIISMIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GTAVGTASTIGIVIMGLAHGFGYPLPIVAGAVISGSFIGDRTSPLAGNVILLSDMGEIEQ
HHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHH
YNVLKSLFKTAIPTYILTGLLYYLLSLHINISSPYTFDNLAAIILKNYKINFFLFLAPIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
IITLAFFRIPTKINLSIAVLLSYFVSLLNGYNLIDSLKVIMMGNVSNIPEFKSFFSGGGM
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCH
VSIFPMIGVVTFATALSGILEGTGIIKAVFKKAQKIKNPKIAYLVTMLLSTLMAVITCNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ALSVILPSRIMLEVFRNLNVKSDMMVRAIADSGMILAGIIPWNLAAMFLSAVLGVKVIDY
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LPYAYLNLLFPILSILIVFIESNKQYSNVLMEEF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]