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The map label for this gene is glmS [H]

Identifier: 167039602

GI number: 167039602

Start: 971935

End: 973761

Strand: Direct

Name: glmS [H]

Synonym: Teth514_0950

Alternate gene names: 167039602

Gene position: 971935-973761 (Clockwise)

Preceding gene: 167039601

Following gene: 167039603

Centisome position: 39.55

GC content: 36.84

Gene sequence:

>1827_bases
ATGTGTGGAATTGTAGGATATATTGGCGATAAACAGGCGACGCCAATACTTTTAGAAGGATTGACAAAATTGGAGTATCG
AGGCTATGATTCAGCAGGAATTGCCATTTTAAATGATGGCAATATAAATATAAAGAAAGCAAAGGGAAGATTAAACGTCC
TAAAAGAGCTTGTTGAAAAAGATAATATGGTAGGGACAATAGGCATAGGACACACAAGGTGGGCTACGCATGGTGAACCA
TCTGATACAAACTCTCATCCTCATTTATCCCAATCAGGGCTAATTGCAGTAGTCCACAATGGCATAATTGAAAACTATCT
TCCACTGAAGAAATGGCTGTTAGAGGAAGGTTATACCTTTAAGTCTGAGACTGATACAGAAGTTGTAGCAAATTTGCTGG
AGTATTATTACAATGGCGATATAGTAGAGGCTGTGAAAAAAGTTTTAGACAGAATTGAAGGTTCTTATGCCTTAGGCGTT
TTGTGCAAAAACAATCCCGATATGATTGTAGCTGCAAGAAAAGAAGCACCTCTTATAGTTGGAATAGGCAATGGTGAAAA
CTTTATTGCATCTGATATCCCAGCTATATTAAAACATACAAGAAGTGTATATTTTCTTGATGATCATGAGATTGCCATAA
TTAAAAAAGACAGCGTAGAGTTTATAGACATGTTTGGAAGGCAAGTAGAAAAATCGCTTTTTGAAGTAAAATGGGATGTA
GAGGCGGCTGAAAAGGGCGGTTATGAACATTTCATGATAAAAGAAATTCACGAGCAGCCAAGCGCTATAAAAGATACGTT
AAGAGGCAGAATAATTGATGATTCAGAAATAGTTTTAGATGATGTGAAAATTACAAAAGAAGACCTTGAAAAGATAGATA
AAATTTTTATTGTAGCCTGTGGAACAGCTTATCATGCAGGTGTTGTTGGGAAATACGTCATAGAAAATCTTGCGAGAATA
CCTGTTGAAGTAGATGTCGCTTCAGAATTTAGATATAGAAACCCCTTAGTAAATGAAAGAACTCTTACAATTGTAATAAG
CCAGTCAGGGGAGACAGCAGATACTATAGCTGCGTTAAAAGAAGCTAAGAAAAAAGGGTCAAGAGTTATAGCCATTACAA
ACGTCGTTGGAAGTTCTGTCTCCAGAGAAGCAGATGATGTACTATACACATGGGCAGGACCTGAAATAGCTGTAGCTTCT
ACCAAAGCTTATACTACGCAACTTATAGCCCTTTATCTTATAGCTATGGACCTTGCAATAAAAAGAGGGATAATAACTAA
AACAAAGGTTATGGAACTTTGCACAGAATTAAAGAAGCTCCCAGAAAAAGTTCAGTACCTTCTTGACAACAAAGAGACAA
TTCAAAAATTTGCTTATGAACATTACAACGCAAAAGACGTTTTTTACATTGGAAGAGGACTGGACTATGCCGTTGCTATG
GAGGGTTCTTTAAAACTCAAAGAAATATCTTATATTCATTCAGAGGCTTATCCGGCTGGTGAATTAAAACACGGTACTTT
GGCCCTTGTAGAAGAGGGAACACTTGTGATAGCTCTTGCAACACAAGATGACCTTTTTGAAAAGATGCTTAGTAATATAA
AAGAAGTAAAAGCAAGAGGTGGTTTTTTAGTCGCCTTTGCAAAGCAAGGTAATTTGCAGCTGGAGGGCGTTGTAGATAAA
GTAATATATATACCTGAAACGCTTAAAGAGCTTACTCCAGTATTGACAGTTGTGCCTTTGCAACTTTTAGCATATTATAT
GGCAGTAGAAAAAGGATGTGACGTAGATAAACCGCGTAATCTTGCAAAGTCAGTAACTGTAGAGTAA

Upstream 100 bases:

>100_bases
CCTGCGACCGATAAAGGACTGGTAAAACCACAGGCGACTGTGGCATAGAGCAGTCTGGGCAGGGAGGAATCTTTATTACA
AAAGTGAGAGGAGACCGAGT

Downstream 100 bases:

>100_bases
TGGAGGTCAAAAGGCTGAAGAGTTGTTGTATATTTCATTTAAATCTTTTCCCTGTGTGAAAAAAGTGGTTCCGTTGAGTG
AGTGTTAAGGGAAAAGGATT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGYIGDKQATPILLEGLTKLEYRGYDSAGIAILNDGNINIKKAKGRLNVLKELVEKDNMVGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLLEEGYTFKSETDTEVVANLLEYYYNGDIVEAVKKVLDRIEGSYALGV
LCKNNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKHTRSVYFLDDHEIAIIKKDSVEFIDMFGRQVEKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPSAIKDTLRGRIIDDSEIVLDDVKITKEDLEKIDKIFIVACGTAYHAGVVGKYVIENLARI
PVEVDVASEFRYRNPLVNERTLTIVISQSGETADTIAALKEAKKKGSRVIAITNVVGSSVSREADDVLYTWAGPEIAVAS
TKAYTTQLIALYLIAMDLAIKRGIITKTKVMELCTELKKLPEKVQYLLDNKETIQKFAYEHYNAKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLVIALATQDDLFEKMLSNIKEVKARGGFLVAFAKQGNLQLEGVVDK
VIYIPETLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGYIGDKQATPILLEGLTKLEYRGYDSAGIAILNDGNINIKKAKGRLNVLKELVEKDNMVGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLLEEGYTFKSETDTEVVANLLEYYYNGDIVEAVKKVLDRIEGSYALGV
LCKNNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKHTRSVYFLDDHEIAIIKKDSVEFIDMFGRQVEKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPSAIKDTLRGRIIDDSEIVLDDVKITKEDLEKIDKIFIVACGTAYHAGVVGKYVIENLARI
PVEVDVASEFRYRNPLVNERTLTIVISQSGETADTIAALKEAKKKGSRVIAITNVVGSSVSREADDVLYTWAGPEIAVAS
TKAYTTQLIALYLIAMDLAIKRGIITKTKVMELCTELKKLPEKVQYLLDNKETIQKFAYEHYNAKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLVIALATQDDLFEKMLSNIKEVKARGGFLVAFAKQGNLQLEGVVDK
VIYIPETLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE
>Mature_608_residues
MCGIVGYIGDKQATPILLEGLTKLEYRGYDSAGIAILNDGNINIKKAKGRLNVLKELVEKDNMVGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLLEEGYTFKSETDTEVVANLLEYYYNGDIVEAVKKVLDRIEGSYALGV
LCKNNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKHTRSVYFLDDHEIAIIKKDSVEFIDMFGRQVEKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPSAIKDTLRGRIIDDSEIVLDDVKITKEDLEKIDKIFIVACGTAYHAGVVGKYVIENLARI
PVEVDVASEFRYRNPLVNERTLTIVISQSGETADTIAALKEAKKKGSRVIAITNVVGSSVSREADDVLYTWAGPEIAVAS
TKAYTTQLIALYLIAMDLAIKRGIITKTKVMELCTELKKLPEKVQYLLDNKETIQKFAYEHYNAKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLVIALATQDDLFEKMLSNIKEVKARGGFLVAFAKQGNLQLEGVVDK
VIYIPETLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=37.6093294460641, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=37.3177842565598, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI29570798, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=46.9155844155844, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1788651, Length=200, Percent_Identity=29.5, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082251, Length=314, Percent_Identity=22.9299363057325, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=39.9538106235566, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=38.4792626728111, Blast_Score=306, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=38.4792626728111, Blast_Score=305, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6322745, Length=432, Percent_Identity=39.5833333333333, Blast_Score=305, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=31.8706697459584, Blast_Score=217, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=41.9512195121951, Blast_Score=136, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323958, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=36.9883040935673, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI28573187, Length=145, Percent_Identity=32.4137931034483, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67388; Mature: 67388

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGDKQATPILLEGLTKLEYRGYDSAGIAILNDGNINIKKAKGRLNVLKELVEK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHC
DNMVGTIGIGHTRWATHGEPSDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLLEEGYTF
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEE
KSETDTEVVANLLEYYYNGDIVEAVKKVLDRIEGSYALGVLCKNNPDMIVAARKEAPLIV
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GIGNGENFIASDIPAILKHTRSVYFLDDHEIAIIKKDSVEFIDMFGRQVEKSLFEVKWDV
EECCCCCCHHHHHHHHHHCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHEEECC
EAAEKGGYEHFMIKEIHEQPSAIKDTLRGRIIDDSEIVLDDVKITKEDLEKIDKIFIVAC
CHHHCCCCCHHHHHHHHCCHHHHHHHHCCCEECCCCEEEECCCCCHHHHHHHCEEEEEEE
GTAYHAGVVGKYVIENLARIPVEVDVASEFRYRNPLVNERTLTIVISQSGETADTIAALK
CCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHH
EAKKKGSRVIAITNVVGSSVSREADDVLYTWAGPEIAVASTKAYTTQLIALYLIAMDLAI
HHHHCCCEEEEEEEHHCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
KRGIITKTKVMELCTELKKLPEKVQYLLDNKETIQKFAYEHYNAKDVFYIGRGLDYAVAM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEE
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLVIALATQDDLFEKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHHHHCC
GFLVAFAKQGNLQLEGVVDKVIYIPETLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRN
CEEEEEECCCCEEEEEEHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LAKSVTVE
HHHCCCCC
>Mature Secondary Structure
MCGIVGYIGDKQATPILLEGLTKLEYRGYDSAGIAILNDGNINIKKAKGRLNVLKELVEK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHC
DNMVGTIGIGHTRWATHGEPSDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLLEEGYTF
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEE
KSETDTEVVANLLEYYYNGDIVEAVKKVLDRIEGSYALGVLCKNNPDMIVAARKEAPLIV
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GIGNGENFIASDIPAILKHTRSVYFLDDHEIAIIKKDSVEFIDMFGRQVEKSLFEVKWDV
EECCCCCCHHHHHHHHHHCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHEEECC
EAAEKGGYEHFMIKEIHEQPSAIKDTLRGRIIDDSEIVLDDVKITKEDLEKIDKIFIVAC
CHHHCCCCCHHHHHHHHCCHHHHHHHHCCCEECCCCEEEECCCCCHHHHHHHCEEEEEEE
GTAYHAGVVGKYVIENLARIPVEVDVASEFRYRNPLVNERTLTIVISQSGETADTIAALK
CCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHH
EAKKKGSRVIAITNVVGSSVSREADDVLYTWAGPEIAVASTKAYTTQLIALYLIAMDLAI
HHHHCCCEEEEEEEHHCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
KRGIITKTKVMELCTELKKLPEKVQYLLDNKETIQKFAYEHYNAKDVFYIGRGLDYAVAM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEE
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLVIALATQDDLFEKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHHHHCC
GFLVAFAKQGNLQLEGVVDKVIYIPETLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRN
CEEEEEECCCCEEEEEEHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LAKSVTVE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]