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The map label for this gene is fusA [H]

Identifier: 167039482

GI number: 167039482

Start: 862970

End: 865009

Strand: Direct

Name: fusA [H]

Synonym: Teth514_0828

Alternate gene names: 167039482

Gene position: 862970-865009 (Clockwise)

Preceding gene: 167039481

Following gene: 167039483

Centisome position: 35.12

GC content: 36.27

Gene sequence:

>2040_bases
ATGAAGGATTACAAAACTAATCAAATAAGAAATGTAGGATTAGTTTCCCACGGTGGAGCCGGTAAAACTACATTAACTGA
GGCATTCCTTTTCAACACAAAAGTTATTGATAGAATGGGGCGCGTAGAAAATGGCACTACTGTATCTGACTATGACACGG
AGGAAATTGCCAGGCAGATATCTATTTCCACATCAGTAATTCCAGTGGAATGGAGAGAGTATAAAATTAATATATTAGAT
ATGCCAGGGTATTTTGATTTCTTTGGAGAAGTTGTAAGTGGCTTGCGAGTTGTAGACAGTGTTATAATACCTGTGTGTGC
TGCTTCTGGTGTAGAAGTGGGAACTGAAAAAGTGTTTAGTTTGGCTCAAAAGAATAAGTTGCCTATTATATTTTTTATTA
ACAAAATGGATAGAGAAAATGCAGATTATTTTAAAACGTTAAATCAATTGAGGGAGAAATTTAGTAATAAGGTTATTCCT
CTGACATTTCCTATTGGAAGCGAACAAAGTTTTAAAGGCTATGTAGACGTTCTTACTCAAAAAGCATACGTTTACGATGA
AAAAGGGGTAAAGGAGACAGAAGTACCGGCAGATTTGATGGATAAAGTTTTATCGGCCAAAGAGGAATTGATTGAGAACA
TTGCTGAAAACGATGAAACTTTAATGGAAAAGTACTTTGGCGGAGAAGAATTTACACAAGAAGAAATGAAAGAAGGAATC
AAAAACAGCATAAGAATTGGAGAGTTAATGCCTGTTTTATGCGGTTCAAGCCTTAAAAATATTGGAGCAGATAAATTATT
AGATGCCATTGTGGAATTTTTGCCATCACCTCTGGATATAGAAAGAGAAAAAGTTAGTGAAAATGGTCCAGTAGCTGCAT
TTGTATTTAAAACTATAGCAGATCCTTATGTAGGAAGACTCTCTATTTTTAAGGTTGTATCAGGTGCTTTGACTTCTGAT
TCTATGCTGCTTAACTCAAATAAGCAGATGCAAGAGAAAATAAGCCAGCTTTACATTTTAAGAGGTAAAAAGCAGATGCC
TGTATCTAAGTTAGTAGCAGGAGATATAGGAGCAGTTGCAAAGCTTCAATATACAATGACAGGAGATACCTTATGTGACA
CTTCTAAACTTGTGACATTAGCACCTATCGATTTCCCACAGCCTACACTTTCACTTGCTATTGAACCTAAATCCAAAGGG
GATGAGGAGAAAATTAGCAATGGGCTCCAAAGGTTGCAAGAGGAAGATCCGACTTTTAAAGTTGAAAAAAATTTAGAGAC
GGGTCAGATGATAGTTTACGGAATGGGAGAGCAGCATATAGAAGTAATTTCTAAAAAGTTGATGAACAAGTTTGGAGTAG
AATGTACCTTGACAGACCCAATTGTACCCTATAGAGAGACGATAAAGGGTAAAGTCAAAGTAGAAGGAAAGCATAAAAAG
CAGACAGGTGGACATGGACAATATGGTCATGTGTGGATTGAATTTGAGCCAAATCCCAACAGTGAATTTGAGTTTGAAGA
TAAAATCTTTGGTGGAGCTGTTCCTAAACAATATATTCCAGCAGTAGAAAAAGGCTTGAGAGAAAGTATGAAAGAAGGTG
TGCTTGCTCGTTATCCTGTTGTAAACATTAAAGCTACTTTGGTAGATGGTTCCTACCATCCTGTTGATTCTTCTGAAATG
GCTTTCAAAATTGCTGCATCTCTTGCTTTTAAAAAGGGAATGGAACAAGCAAATCCAGTTCTTTTAGAACCTATTATGAG
AGTAGAAGTGGTGGTACCTGAAGAATACATGGGAGATATCATTGGGGATTTGAATAAGAGAAGAGGAAGAATTTTAGGCA
TGGAGTCAAAAGACAATTTAGAAGTAATCACAGCAGAAGTGCCTTTGGCTGAAATGAATAGATATGCGACAGATTTAAGG
TCTTTGACACAAGCAAGAGGAGACTTCAAAATGACTTTTGCAAGATATGAAGAAGCTCCACCTAATGTGGCACAAAAGAT
AATAGAAGAAAGGAAGAAATTAAAAGAAAAAGAAGAATAA

Upstream 100 bases:

>100_bases
AGATTTTTTATTAAAAAAATATCAAAAAAATAAAGGAAAATTTCAAAATGTATAGAATAATAATATTAAAGATTATTTGC
GATAAGATAGGGGGATATGT

Downstream 100 bases:

>100_bases
GCCTGCTTTTGCAGGCTTTATTTTTATGTGCGCCCGGCATGGGCGATAGCTAGGCGGTGAAAGTCCGCTGTGGGCTTGGT
AGTGGGAACCACTAGCCAAG

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKDYKTNQIRNVGLVSHGGAGKTTLTEAFLFNTKVIDRMGRVENGTTVSDYDTEEIARQISISTSVIPVEWREYKINILD
MPGYFDFFGEVVSGLRVVDSVIIPVCAASGVEVGTEKVFSLAQKNKLPIIFFINKMDRENADYFKTLNQLREKFSNKVIP
LTFPIGSEQSFKGYVDVLTQKAYVYDEKGVKETEVPADLMDKVLSAKEELIENIAENDETLMEKYFGGEEFTQEEMKEGI
KNSIRIGELMPVLCGSSLKNIGADKLLDAIVEFLPSPLDIEREKVSENGPVAAFVFKTIADPYVGRLSIFKVVSGALTSD
SMLLNSNKQMQEKISQLYILRGKKQMPVSKLVAGDIGAVAKLQYTMTGDTLCDTSKLVTLAPIDFPQPTLSLAIEPKSKG
DEEKISNGLQRLQEEDPTFKVEKNLETGQMIVYGMGEQHIEVISKKLMNKFGVECTLTDPIVPYRETIKGKVKVEGKHKK
QTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMKEGVLARYPVVNIKATLVDGSYHPVDSSEM
AFKIAASLAFKKGMEQANPVLLEPIMRVEVVVPEEYMGDIIGDLNKRRGRILGMESKDNLEVITAEVPLAEMNRYATDLR
SLTQARGDFKMTFARYEEAPPNVAQKIIEERKKLKEKEE

Sequences:

>Translated_679_residues
MKDYKTNQIRNVGLVSHGGAGKTTLTEAFLFNTKVIDRMGRVENGTTVSDYDTEEIARQISISTSVIPVEWREYKINILD
MPGYFDFFGEVVSGLRVVDSVIIPVCAASGVEVGTEKVFSLAQKNKLPIIFFINKMDRENADYFKTLNQLREKFSNKVIP
LTFPIGSEQSFKGYVDVLTQKAYVYDEKGVKETEVPADLMDKVLSAKEELIENIAENDETLMEKYFGGEEFTQEEMKEGI
KNSIRIGELMPVLCGSSLKNIGADKLLDAIVEFLPSPLDIEREKVSENGPVAAFVFKTIADPYVGRLSIFKVVSGALTSD
SMLLNSNKQMQEKISQLYILRGKKQMPVSKLVAGDIGAVAKLQYTMTGDTLCDTSKLVTLAPIDFPQPTLSLAIEPKSKG
DEEKISNGLQRLQEEDPTFKVEKNLETGQMIVYGMGEQHIEVISKKLMNKFGVECTLTDPIVPYRETIKGKVKVEGKHKK
QTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMKEGVLARYPVVNIKATLVDGSYHPVDSSEM
AFKIAASLAFKKGMEQANPVLLEPIMRVEVVVPEEYMGDIIGDLNKRRGRILGMESKDNLEVITAEVPLAEMNRYATDLR
SLTQARGDFKMTFARYEEAPPNVAQKIIEERKKLKEKEE
>Mature_679_residues
MKDYKTNQIRNVGLVSHGGAGKTTLTEAFLFNTKVIDRMGRVENGTTVSDYDTEEIARQISISTSVIPVEWREYKINILD
MPGYFDFFGEVVSGLRVVDSVIIPVCAASGVEVGTEKVFSLAQKNKLPIIFFINKMDRENADYFKTLNQLREKFSNKVIP
LTFPIGSEQSFKGYVDVLTQKAYVYDEKGVKETEVPADLMDKVLSAKEELIENIAENDETLMEKYFGGEEFTQEEMKEGI
KNSIRIGELMPVLCGSSLKNIGADKLLDAIVEFLPSPLDIEREKVSENGPVAAFVFKTIADPYVGRLSIFKVVSGALTSD
SMLLNSNKQMQEKISQLYILRGKKQMPVSKLVAGDIGAVAKLQYTMTGDTLCDTSKLVTLAPIDFPQPTLSLAIEPKSKG
DEEKISNGLQRLQEEDPTFKVEKNLETGQMIVYGMGEQHIEVISKKLMNKFGVECTLTDPIVPYRETIKGKVKVEGKHKK
QTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMKEGVLARYPVVNIKATLVDGSYHPVDSSEM
AFKIAASLAFKKGMEQANPVLLEPIMRVEVVVPEEYMGDIIGDLNKRRGRILGMESKDNLEVITAEVPLAEMNRYATDLR
SLTQARGDFKMTFARYEEAPPNVAQKIIEERKKLKEKEE

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=690, Percent_Identity=34.0579710144928, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI19923640, Length=715, Percent_Identity=30.4895104895105, Blast_Score=334, Evalue=2e-91,
Organism=Homo sapiens, GI25306287, Length=714, Percent_Identity=29.1316526610644, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI25306283, Length=444, Percent_Identity=30.8558558558559, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI217272892, Length=812, Percent_Identity=20.8128078817734, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217272894, Length=812, Percent_Identity=20.8128078817734, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI157426893, Length=174, Percent_Identity=31.0344827586207, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=32.8467153284672, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4503483, Length=152, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI94966752, Length=145, Percent_Identity=26.2068965517241, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789738, Length=695, Percent_Identity=43.8848920863309, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790835, Length=461, Percent_Identity=28.6334056399132, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI48994988, Length=169, Percent_Identity=33.7278106508876, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17533571, Length=696, Percent_Identity=32.7586206896552, Blast_Score=397, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17556745, Length=712, Percent_Identity=24.8595505617978, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17506493, Length=847, Percent_Identity=23.4946871310508, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17552882, Length=802, Percent_Identity=20.9476309226933, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557151, Length=155, Percent_Identity=31.6129032258064, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323098, Length=699, Percent_Identity=33.4763948497854, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322359, Length=787, Percent_Identity=27.3189326556544, Blast_Score=287, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6324707, Length=507, Percent_Identity=22.4852071005917, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320593, Length=507, Percent_Identity=22.4852071005917, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=155, Percent_Identity=30.3225806451613, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582462, Length=690, Percent_Identity=35.6521739130435, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI221458488, Length=693, Percent_Identity=28.1385281385281, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24585709, Length=835, Percent_Identity=22.7544910179641, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24585711, Length=835, Percent_Identity=22.5149700598802, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24585713, Length=835, Percent_Identity=22.5149700598802, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 75970; Mature: 75970

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYKTNQIRNVGLVSHGGAGKTTLTEAFLFNTKVIDRMGRVENGTTVSDYDTEEIARQI
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SISTSVIPVEWREYKINILDMPGYFDFFGEVVSGLRVVDSVIIPVCAASGVEVGTEKVFS
HHCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAQKNKLPIIFFINKMDRENADYFKTLNQLREKFSNKVIPLTFPIGSEQSFKGYVDVLTQ
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
KAYVYDEKGVKETEVPADLMDKVLSAKEELIENIAENDETLMEKYFGGEEFTQEEMKEGI
HHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KNSIRIGELMPVLCGSSLKNIGADKLLDAIVEFLPSPLDIEREKVSENGPVAAFVFKTIA
HHCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHC
DPYVGRLSIFKVVSGALTSDSMLLNSNKQMQEKISQLYILRGKKQMPVSKLVAGDIGAVA
CCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEE
KLQYTMTGDTLCDTSKLVTLAPIDFPQPTLSLAIEPKSKGDEEKISNGLQRLQEEDPTFK
EEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEE
VEKNLETGQMIVYGMGEQHIEVISKKLMNKFGVECTLTDPIVPYRETIKGKVKVEGKHKK
EECCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCEEEECCCCCC
QTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMKEGVLARYPV
CCCCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCE
VNIKATLVDGSYHPVDSSEMAFKIAASLAFKKGMEQANPVLLEPIMRVEVVVPEEYMGDI
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHCCCCEEEEECCHHHHHHH
IGDLNKRRGRILGMESKDNLEVITAEVPLAEMNRYATDLRSLTQARGDFKMTFARYEEAP
HHHHHHCCCCEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCC
PNVAQKIIEERKKLKEKEE
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDYKTNQIRNVGLVSHGGAGKTTLTEAFLFNTKVIDRMGRVENGTTVSDYDTEEIARQI
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SISTSVIPVEWREYKINILDMPGYFDFFGEVVSGLRVVDSVIIPVCAASGVEVGTEKVFS
HHCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAQKNKLPIIFFINKMDRENADYFKTLNQLREKFSNKVIPLTFPIGSEQSFKGYVDVLTQ
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
KAYVYDEKGVKETEVPADLMDKVLSAKEELIENIAENDETLMEKYFGGEEFTQEEMKEGI
HHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KNSIRIGELMPVLCGSSLKNIGADKLLDAIVEFLPSPLDIEREKVSENGPVAAFVFKTIA
HHCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHC
DPYVGRLSIFKVVSGALTSDSMLLNSNKQMQEKISQLYILRGKKQMPVSKLVAGDIGAVA
CCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEE
KLQYTMTGDTLCDTSKLVTLAPIDFPQPTLSLAIEPKSKGDEEKISNGLQRLQEEDPTFK
EEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEE
VEKNLETGQMIVYGMGEQHIEVISKKLMNKFGVECTLTDPIVPYRETIKGKVKVEGKHKK
EECCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCEEEECCCCCC
QTGGHGQYGHVWIEFEPNPNSEFEFEDKIFGGAVPKQYIPAVEKGLRESMKEGVLARYPV
CCCCCCCEEEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCE
VNIKATLVDGSYHPVDSSEMAFKIAASLAFKKGMEQANPVLLEPIMRVEVVVPEEYMGDI
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHCCCCEEEEECCHHHHHHH
IGDLNKRRGRILGMESKDNLEVITAEVPLAEMNRYATDLRSLTQARGDFKMTFARYEEAP
HHHHHHCCCCEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCC
PNVAQKIIEERKKLKEKEE
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA