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The map label for this gene is patA [H]

Identifier: 167039473

GI number: 167039473

Start: 850566

End: 851993

Strand: Direct

Name: patA [H]

Synonym: Teth514_0819

Alternate gene names: 167039473

Gene position: 850566-851993 (Clockwise)

Preceding gene: 167039472

Following gene: 167039474

Centisome position: 34.61

GC content: 37.25

Gene sequence:

>1428_bases
ATGTATGAAGTAACAAAGGGGAAAGTGAAGGATGATATTCCGGAATATATAACTTTAGAAGAAGCACTTACATTAAACAA
AAATCAAGTCAGAGAAAATTACAAAGAATACATAAATTCAGTTTTTGTCTCTATGCTTTCAATGCTTCAGTTTGATAAAC
TTTTTGTAAGAGCTAAGGGAGTTTCAGTATGGGACAATGAAGGAAACGAATATTATGACTTTTTAGGAGGATATGGTGCT
TTAAATTTAGGGCATAACCCCGATGAGGTCATCGAAGCTGTAGAAAAAGTAAAATATATGCCTAATATATTGCAAGCGGC
TATTGGAAATTTGCCAGGAGTTCTTGCTCATAATCTTGCAAAAGTGACACCAGGGAATCTTAAAAGGAGCTTTTTCTGTA
ACAGCGGAGCTGAAGCAGTAGAAGGAGCTTTAAAACTTGCTAAAATTGCTTCAGGGAAACAAAAAATAGTTTACTGCCAA
AACTCTTTTCACGGCAAATCCATGGGTGCCCTTTCAGTGACGGGACGAGAAAAATATCAAAAGTATTTTAAACCACTTGT
GCCGGAGACAGTTCCTATTCCATTTGGAGATGAAAAAGCTTTGGAGGAAGCTTTGAAAGGTAGAGATGTTGCTGCTTTTA
TAGTAGAGCCTATCCAAGGGGAAGGCGGAGTTATCGTTCCTCCTGAGGGATATTTGAAAAAGGTAAGAGAGCTCTGTACT
AAGTATGATGCTTATTTGATTTTAGATGAGGTGCAAACTGGGTTTGGAAGAACAGGAAAAATGTTTGCATGTGAGCACGA
AGGAGTGGTTCCTGACATAATGTGCCTTGCGAAGTCTTTAGGTGGAGGAGTTATGCCTATCGGTGCCTATATAACCACAG
AGGAGATATGGCAAAAAGCTTATGGGACTATGGAAAAAGCTCTTTTACATACTTCTACTTTTGGCGGTAATACCTATGCT
TGTGCAGCTGCGATTGCTTCAATACAAGCTATTATAGAGAAAAAGCTTCCTGATGCTGCAAAAGAAAAAGGTGGATACTT
TTTAGGTCGACTGAAAGAATTAAAAGAAAAACATCCAAAACTTATAAAAGATGTTAGAGGAAAGGGGCTTTTAATAGGAG
TAGAGTTTAATCAACCAGAAGGTGGACTTCTTGACAAGATTTCTGGAGGAGCTATCTCAAAGTTTTCAAGTGAATATCTC
GGCTCTTTAATTGCTGGAGAGCTTCAAAATAAACACAGAATTATAACGGCTTACACTTTGAATAACCCAAATGTAATAAG
ATTAGAGCCACCTTTAATTGTGACAAAAGAACAAATTGACAAAGTTGTAGATGCTTTAGATGAAATTCTCACAAGAAGTA
GTAGCTTCTTAGGGATTACTGTCTCGGGAGCAAAAACTGTTTTAGGATCGTTATTTAAAAGGCAGTAA

Upstream 100 bases:

>100_bases
AAAGTATTAAATATGCTAACAATAGTTGCGAACATTGTGGTCATGACCATCATCACCATCATCACCACCACAGACATTAA
AGATAAAGGAGAGATGAAAA

Downstream 100 bases:

>100_bases
ATTGAAAGAGGTGAATTAACTTTGAGAGAATTGTTTGAAAAAGGAATAACTTTTGAGGAATTTGTAAAAGAATCGGAGGA
GAACATTGCTAAAAGAATAA

Product: class III aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MYEVTKGKVKDDIPEYITLEEALTLNKNQVRENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDNEGNEYYDFLGGYGA
LNLGHNPDEVIEAVEKVKYMPNILQAAIGNLPGVLAHNLAKVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKQKIVYCQ
NSFHGKSMGALSVTGREKYQKYFKPLVPETVPIPFGDEKALEEALKGRDVAAFIVEPIQGEGGVIVPPEGYLKKVRELCT
KYDAYLILDEVQTGFGRTGKMFACEHEGVVPDIMCLAKSLGGGVMPIGAYITTEEIWQKAYGTMEKALLHTSTFGGNTYA
CAAAIASIQAIIEKKLPDAAKEKGGYFLGRLKELKEKHPKLIKDVRGKGLLIGVEFNQPEGGLLDKISGGAISKFSSEYL
GSLIAGELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRSSSFLGITVSGAKTVLGSLFKRQ

Sequences:

>Translated_475_residues
MYEVTKGKVKDDIPEYITLEEALTLNKNQVRENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDNEGNEYYDFLGGYGA
LNLGHNPDEVIEAVEKVKYMPNILQAAIGNLPGVLAHNLAKVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKQKIVYCQ
NSFHGKSMGALSVTGREKYQKYFKPLVPETVPIPFGDEKALEEALKGRDVAAFIVEPIQGEGGVIVPPEGYLKKVRELCT
KYDAYLILDEVQTGFGRTGKMFACEHEGVVPDIMCLAKSLGGGVMPIGAYITTEEIWQKAYGTMEKALLHTSTFGGNTYA
CAAAIASIQAIIEKKLPDAAKEKGGYFLGRLKELKEKHPKLIKDVRGKGLLIGVEFNQPEGGLLDKISGGAISKFSSEYL
GSLIAGELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRSSSFLGITVSGAKTVLGSLFKRQ
>Mature_475_residues
MYEVTKGKVKDDIPEYITLEEALTLNKNQVRENYKEYINSVFVSMLSMLQFDKLFVRAKGVSVWDNEGNEYYDFLGGYGA
LNLGHNPDEVIEAVEKVKYMPNILQAAIGNLPGVLAHNLAKVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKQKIVYCQ
NSFHGKSMGALSVTGREKYQKYFKPLVPETVPIPFGDEKALEEALKGRDVAAFIVEPIQGEGGVIVPPEGYLKKVRELCT
KYDAYLILDEVQTGFGRTGKMFACEHEGVVPDIMCLAKSLGGGVMPIGAYITTEEIWQKAYGTMEKALLHTSTFGGNTYA
CAAAIASIQAIIEKKLPDAAKEKGGYFLGRLKELKEKHPKLIKDVRGKGLLIGVEFNQPEGGLLDKISGGAISKFSSEYL
GSLIAGELQNKHRIITAYTLNNPNVIRLEPPLIVTKEQIDKVVDALDEILTRSSSFLGITVSGAKTVLGSLFKRQ

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=403, Percent_Identity=32.258064516129, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI284507298, Length=284, Percent_Identity=37.6760563380282, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI13994255, Length=485, Percent_Identity=28.8659793814433, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=31.353919239905, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=31.353919239905, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=28.8095238095238, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=31.7258883248731, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI188536080, Length=251, Percent_Identity=28.6852589641434, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679950, Length=251, Percent_Identity=28.6852589641434, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679946, Length=251, Percent_Identity=28.6852589641434, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI145693181, Length=445, Percent_Identity=44.9438202247191, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1788044, Length=438, Percent_Identity=35.1598173515982, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=35.5889724310777, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1789016, Length=401, Percent_Identity=30.6733167082294, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=32.2115384615385, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786991, Length=445, Percent_Identity=28.0898876404494, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786349, Length=343, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=32.9326923076923, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI25144274, Length=406, Percent_Identity=30.2955665024631, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=29.7674418604651, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=25.462962962963, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=467, Percent_Identity=25.0535331905782, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=152, Percent_Identity=28.2894736842105, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=34.2857142857143, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=33.0166270783848, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324386, Length=318, Percent_Identity=27.6729559748428, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=385, Percent_Identity=25.1948051948052, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357415, Length=381, Percent_Identity=35.9580052493438, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=30.6976744186047, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI161085790, Length=477, Percent_Identity=29.769392033543, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28574759, Length=482, Percent_Identity=29.8755186721992, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI281366494, Length=391, Percent_Identity=24.0409207161125, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667139, Length=391, Percent_Identity=24.0409207161125, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667143, Length=391, Percent_Identity=24.0409207161125, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 52002; Mature: 52002

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEVTKGKVKDDIPEYITLEEALTLNKNQVRENYKEYINSVFVSMLSMLQFDKLFVRAKG
CCCCCCCCCHHCCCHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VSVWDNEGNEYYDFLGGYGALNLGHNPDEVIEAVEKVKYMPNILQAAIGNLPGVLAHNLA
CEEECCCCCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKQKIVYCQNSFHGKSMGALSVTGREKYQ
HCCCCCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECCHHHHH
KYFKPLVPETVPIPFGDEKALEEALKGRDVAAFIVEPIQGEGGVIVPPEGYLKKVRELCT
HHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHH
KYDAYLILDEVQTGFGRTGKMFACEHEGVVPDIMCLAKSLGGGVMPIGAYITTEEIWQKA
HHCCEEEEEHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEECCEEEHHHHHHHH
YGTMEKALLHTSTFGGNTYACAAAIASIQAIIEKKLPDAAKEKGGYFLGRLKELKEKHPK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCHH
LIKDVRGKGLLIGVEFNQPEGGLLDKISGGAISKFSSEYLGSLIAGELQNKHRIITAYTL
HHHHCCCCEEEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
NNPNVIRLEPPLIVTKEQIDKVVDALDEILTRSSSFLGITVSGAKTVLGSLFKRQ
CCCCEEEECCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MYEVTKGKVKDDIPEYITLEEALTLNKNQVRENYKEYINSVFVSMLSMLQFDKLFVRAKG
CCCCCCCCCHHCCCHHEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VSVWDNEGNEYYDFLGGYGALNLGHNPDEVIEAVEKVKYMPNILQAAIGNLPGVLAHNLA
CEEECCCCCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KVTPGNLKRSFFCNSGAEAVEGALKLAKIASGKQKIVYCQNSFHGKSMGALSVTGREKYQ
HCCCCCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECCHHHHH
KYFKPLVPETVPIPFGDEKALEEALKGRDVAAFIVEPIQGEGGVIVPPEGYLKKVRELCT
HHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHH
KYDAYLILDEVQTGFGRTGKMFACEHEGVVPDIMCLAKSLGGGVMPIGAYITTEEIWQKA
HHCCEEEEEHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEECCEEEHHHHHHHH
YGTMEKALLHTSTFGGNTYACAAAIASIQAIIEKKLPDAAKEKGGYFLGRLKELKEKHPK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCHH
LIKDVRGKGLLIGVEFNQPEGGLLDKISGGAISKFSSEYLGSLIAGELQNKHRIITAYTL
HHHHCCCCEEEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
NNPNVIRLEPPLIVTKEQIDKVVDALDEILTRSSSFLGITVSGAKTVLGSLFKRQ
CCCCEEEECCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA