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The map label for this gene is folK [H]

Identifier: 167039467

GI number: 167039467

Start: 845820

End: 846320

Strand: Direct

Name: folK [H]

Synonym: Teth514_0813

Alternate gene names: 167039467

Gene position: 845820-846320 (Clockwise)

Preceding gene: 167039466

Following gene: 167039468

Centisome position: 34.42

GC content: 32.34

Gene sequence:

>501_bases
ATGAGTGAAGTGTATTTATCTTTAGGTTCTAATTTAGGAGATAGGGAAGAAAATTTAAAAAGAGCCGTTTTTGAGTTAGA
ACACTGGGAAGGCATAATTTTAAAGAAGCTTTCTCCTATTTATGAAACAAAACCTGTAGGATATTTAAACCAGGATATGT
TTTTAAATATTGCAGTTGAAGTGGAGACAAACATTGGGCCTTATGACTTATTAAAAGTTGTAAATGAAATTGAAAAAAAA
TTAAAACGAGAAAGACTCATAAGATGGGGTCCAAGGACTATTGATATTGACATACTGTTGTACGATGATATTGAATTAAA
GGATGAAGTGTTGAGTATTCCTCATCCGAGAATATGGGAGAGAGCTTTTGTGTTGATTCCTCTTTCGGATATAAACCCTT
TTATAAAAAAAGGAGATGTGTATATTAAAGATTTAATAGCGGAGTTGCCTGATAAAGAAGGAGTTAAGCTGTATAAAGAG
AATTGGTACAATGGGGTGTAA

Upstream 100 bases:

>100_bases
CAGTTGCTGTTGGGATTGTAAAAGGGGTTGATATTGTACGCGTTCACGATGTAAAGCAGATGTTAAGAGTTGCTAAGATG
ACTGATGCGATGGTGAGAAG

Downstream 100 bases:

>100_bases
AAAATGAAAGTGACAAAAATTTTTACTTTTGACAGTGCCCACAATCTTATAAATTACAATGGGAAGTGTGAGGAGCTTCA
TGGTCATACATATAAGCTGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSEVYLSLGSNLGDREENLKRAVFELEHWEGIILKKLSPIYETKPVGYLNQDMFLNIAVEVETNIGPYDLLKVVNEIEKK
LKRERLIRWGPRTIDIDILLYDDIELKDEVLSIPHPRIWERAFVLIPLSDINPFIKKGDVYIKDLIAELPDKEGVKLYKE
NWYNGV

Sequences:

>Translated_166_residues
MSEVYLSLGSNLGDREENLKRAVFELEHWEGIILKKLSPIYETKPVGYLNQDMFLNIAVEVETNIGPYDLLKVVNEIEKK
LKRERLIRWGPRTIDIDILLYDDIELKDEVLSIPHPRIWERAFVLIPLSDINPFIKKGDVYIKDLIAELPDKEGVKLYKE
NWYNGV
>Mature_165_residues
SEVYLSLGSNLGDREENLKRAVFELEHWEGIILKKLSPIYETKPVGYLNQDMFLNIAVEVETNIGPYDLLKVVNEIEKKL
KRERLIRWGPRTIDIDILLYDDIELKDEVLSIPHPRIWERAFVLIPLSDINPFIKKGDVYIKDLIAELPDKEGVKLYKEN
WYNGV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=36.5671641791045, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=39.5522388059701, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19440; Mature: 19309

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVYLSLGSNLGDREENLKRAVFELEHWEGIILKKLSPIYETKPVGYLNQDMFLNIAVE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCCCCCCEEEEEEEE
VETNIGPYDLLKVVNEIEKKLKRERLIRWGPRTIDIDILLYDDIELKDEVLSIPHPRIWE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHCCCCCCCCC
RAFVLIPLSDINPFIKKGDVYIKDLIAELPDKEGVKLYKENWYNGV
CEEEEEECCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SEVYLSLGSNLGDREENLKRAVFELEHWEGIILKKLSPIYETKPVGYLNQDMFLNIAVE
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCCCCCCEEEEEEEE
VETNIGPYDLLKVVNEIEKKLKRERLIRWGPRTIDIDILLYDDIELKDEVLSIPHPRIWE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHCCCCCCCCC
RAFVLIPLSDINPFIKKGDVYIKDLIAELPDKEGVKLYKENWYNGV
CEEEEEECCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]