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The map label for this gene is adhE [H]

Identifier: 167039286

GI number: 167039286

Start: 652326

End: 654944

Strand: Reverse

Name: adhE [H]

Synonym: Teth514_0627

Alternate gene names: 167039286

Gene position: 654944-652326 (Counterclockwise)

Preceding gene: 167039300

Following gene: 167039282

Centisome position: 26.65

GC content: 36.77

Gene sequence:

>2619_bases
ATGCCTACCTTATTACAAGAAAAAAAGGAAACAAAAGAAAAAACAGAAGTAAAAGAAACAACAGATGTTAAAAAGCAGAT
AGACCTATTAGTAGAAAGAGCGAAAAGAGCACAAGAAAAATTCATGTCATACACCCAAGAGCAAATTAATGAAATAGTCA
AAGCCATGGCACTAGCAGGCATAGAAAAGCATGTAGAACTGGCAAAATTAGCTCATGAAGAGACGAAAATGGGGGTTTAT
GAAGACAAAATAACCAAAAACCTTTTTGCAGTAGAATATGTGTACAATTATATAAAAGACAAAAAAACTGTCGGCATCCT
CAAAGAAAACTTAGAAGAAAATTATATGGAAGTGGCAGAACCTGTAGGAGTTATAGCCGGCGTAACACCTGTCACAAACC
CGACTTCTACAACAATGTTCAAATGCCTCATTGCTATCAAAACAAGAAATCCAATAATTTTCAGCTTCCACCCAAAAGCA
TTAAAATGTAGTATAGAAGCAGCAAAGACGATGTACGAGGCAGCATTAAAGGCTGGTGCACCAGAAGGATGTATAGGATG
GATTGAGACACCCTCAATTGAAGCAACACAACTTCTCATGACACATCCCGATATATCTCTTATCCTAGCAACAGGCGGCG
CCGGAATGGTAAAAGCTGCTTACAGCTCAGGAAAACCCGCCCTTGGCGTAGGTCCTGGCAATGTCCCCTGCTATATTGAA
AAAACTGCAAATATTAAAAGAGCAGTTTCAGATTTAATACTTAGTAAAACTTTTGACAATGGTACAGTATGTGCCTCAGA
GCAAGCTGTAATAATAGATGAAGAAATAGCCGATGAAGTAAAAAAATTAATGAGAGAATATGGTTGCTATTTCTTAAATA
AAGAAGAAACTAAAAAGTTAGAAGAATTCGCTATAGACAAAAACACCGGTTTAATGAATCCAGCAGTTGTAGGTCAACCG
GCAACAAAAATTGCTGAAATGGCTGGATTTAAAGTACCTGAAAACACAAAAATACTTGTAGCTGAATATCCTGCTGTAGG
ACCAGAATATCCTCTCTCCAGAGAAAAGCTAAGTCCAATACTTGCTTTATACACAGTCAAAGATTACAACGAAGGCATAA
AAAGATGTGAAGAAATGACAGAATTCGGCGGACTTGGTCACTCTGCAGTAATACATTCTGAAAACCAACAAATTATTAAT
GAATTTGCAAAAAGAGTACGAGCAGGAAGAATTCTTGTAAACGCCCCTGCTTCTCAAGGAGCTATTGGAGATATTTATAA
CACGGCTATCCCATCTTTGACTTTGGGTTGCGGTACAATGGGTAGAAATTCAACAACAGATAATGTAAGTGTTTATAACC
TTATAAACATAAAACGAGTTTTTATAAGAAAAGAGAGAATGAAATGGTTCAGAGTTCCACCACAAATTTATTTTGAAAGA
GGGTCATTACAATATCTGTCACAAGTAAAAGGCAAAAAAGCCTTTATTGTAACAGACCCTGTGATGGTTAAATTAGGTTT
TGTAGATAAAGTAACGTATCAATTAGATAAGGCAAATATTAAATATGAAATATTCTCTGAAGTTGAACCAGATCCTTCAG
TTGACACTGTAGAAAAAGGGGTAAAAATAATGAGAGGGTTTGAGCCTGACTTACTAATAGCTGTAGGTGGTGGTTCTGCA
ATAGATGCAGCGAAGGGAATGTGGCTTTTCTACGAATACCCTGATACAAAATTCGAAGACTTAAGGTTAAAATTTATGGA
CATAAGAAAAAGAACTTATAGATTTCCTGAACTGGGGAAAAAAGCTTTATTTATCGCAATACCAACCACCAGCGGTACAG
GTTCTGAAGTTACTGCCTTTGCAGTTATAACAGACAAAAAGAAAAATATAAAGTACCCTCTCACAGATTACGAATTAACA
CCAGATATCGCTATAATAGACCCTGACCTCACAATGACAATACCACCCTCTGTCACAGCAGACACTGGTATGGACGCTTT
AACCCATGCTATTGAAGCCTATGTATCTGTAATGGCATCAGACTATACAGACGCTCTCGCAGAAAAAGCTATAAAATTGA
TATTTGAATATCTACCTAAAGCATACAAAAACGGGCAAGATAAAGTCGCCCGCGAAAAGATGCACAATGCTTCATGCATA
GCTGGAATGGCCTTCACAAATGCATTTTTAGGAATAAACCATAGTATGGCTCATATACTTGGTGCTAAATTCCATCTTCC
ACACGGAAGAGCAAATGCAATACTTCTGCCCTATGTCATAGAATACAATGCTGAGTTACCTAAAAAATTTGCTTCATTCC
CACAATATGAATATCCCAAAGCAGCCGAGAAATATGCAGAAATTGCAAAATTCTTGGGACTTCCTGCATCAACCATTGAA
GAAGGAGTAAAAAGCCTCATTGAAGCAATAAAAAATCTTATGAAAGAGCTTAATCTTCCTTTGACACTTAAAGAAGCAGG
CATAAATAAAGAAGAATTCGAAAAACAAATAATGGAAATGTCTGATATAGCCTTTAATGACCAGTGCACCGGTTCAAACC
CAAGAATGCCATTGGTATCCGAAATTGCAGAAATATATAGAAAAGCCTATGGAGAATAA

Upstream 100 bases:

>100_bases
AAATTTGTGTAATATACCCTGAAATTTTTTAGAATCATCTGACAATCTCTTTATTTAAATAAAATATTTTGTTAAATTAT
TAACACATGGAGGTGTTCTT

Downstream 100 bases:

>100_bases
GGGTAAATTTTTAGTTTACCCTTATTCTATTTCCAAAACAGAAGTGAATTTTTCTATAAAAGATACTCCTGAAGTTGTCG
GCAGAAAAGTAGAGGTTACC

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]

Number of amino acids: Translated: 872; Mature: 871

Protein sequence:

>872_residues
MPTLLQEKKETKEKTEVKETTDVKKQIDLLVERAKRAQEKFMSYTQEQINEIVKAMALAGIEKHVELAKLAHEETKMGVY
EDKITKNLFAVEYVYNYIKDKKTVGILKENLEENYMEVAEPVGVIAGVTPVTNPTSTTMFKCLIAIKTRNPIIFSFHPKA
LKCSIEAAKTMYEAALKAGAPEGCIGWIETPSIEATQLLMTHPDISLILATGGAGMVKAAYSSGKPALGVGPGNVPCYIE
KTANIKRAVSDLILSKTFDNGTVCASEQAVIIDEEIADEVKKLMREYGCYFLNKEETKKLEEFAIDKNTGLMNPAVVGQP
ATKIAEMAGFKVPENTKILVAEYPAVGPEYPLSREKLSPILALYTVKDYNEGIKRCEEMTEFGGLGHSAVIHSENQQIIN
EFAKRVRAGRILVNAPASQGAIGDIYNTAIPSLTLGCGTMGRNSTTDNVSVYNLINIKRVFIRKERMKWFRVPPQIYFER
GSLQYLSQVKGKKAFIVTDPVMVKLGFVDKVTYQLDKANIKYEIFSEVEPDPSVDTVEKGVKIMRGFEPDLLIAVGGGSA
IDAAKGMWLFYEYPDTKFEDLRLKFMDIRKRTYRFPELGKKALFIAIPTTSGTGSEVTAFAVITDKKKNIKYPLTDYELT
PDIAIIDPDLTMTIPPSVTADTGMDALTHAIEAYVSVMASDYTDALAEKAIKLIFEYLPKAYKNGQDKVAREKMHNASCI
AGMAFTNAFLGINHSMAHILGAKFHLPHGRANAILLPYVIEYNAELPKKFASFPQYEYPKAAEKYAEIAKFLGLPASTIE
EGVKSLIEAIKNLMKELNLPLTLKEAGINKEEFEKQIMEMSDIAFNDQCTGSNPRMPLVSEIAEIYRKAYGE

Sequences:

>Translated_872_residues
MPTLLQEKKETKEKTEVKETTDVKKQIDLLVERAKRAQEKFMSYTQEQINEIVKAMALAGIEKHVELAKLAHEETKMGVY
EDKITKNLFAVEYVYNYIKDKKTVGILKENLEENYMEVAEPVGVIAGVTPVTNPTSTTMFKCLIAIKTRNPIIFSFHPKA
LKCSIEAAKTMYEAALKAGAPEGCIGWIETPSIEATQLLMTHPDISLILATGGAGMVKAAYSSGKPALGVGPGNVPCYIE
KTANIKRAVSDLILSKTFDNGTVCASEQAVIIDEEIADEVKKLMREYGCYFLNKEETKKLEEFAIDKNTGLMNPAVVGQP
ATKIAEMAGFKVPENTKILVAEYPAVGPEYPLSREKLSPILALYTVKDYNEGIKRCEEMTEFGGLGHSAVIHSENQQIIN
EFAKRVRAGRILVNAPASQGAIGDIYNTAIPSLTLGCGTMGRNSTTDNVSVYNLINIKRVFIRKERMKWFRVPPQIYFER
GSLQYLSQVKGKKAFIVTDPVMVKLGFVDKVTYQLDKANIKYEIFSEVEPDPSVDTVEKGVKIMRGFEPDLLIAVGGGSA
IDAAKGMWLFYEYPDTKFEDLRLKFMDIRKRTYRFPELGKKALFIAIPTTSGTGSEVTAFAVITDKKKNIKYPLTDYELT
PDIAIIDPDLTMTIPPSVTADTGMDALTHAIEAYVSVMASDYTDALAEKAIKLIFEYLPKAYKNGQDKVAREKMHNASCI
AGMAFTNAFLGINHSMAHILGAKFHLPHGRANAILLPYVIEYNAELPKKFASFPQYEYPKAAEKYAEIAKFLGLPASTIE
EGVKSLIEAIKNLMKELNLPLTLKEAGINKEEFEKQIMEMSDIAFNDQCTGSNPRMPLVSEIAEIYRKAYGE
>Mature_871_residues
PTLLQEKKETKEKTEVKETTDVKKQIDLLVERAKRAQEKFMSYTQEQINEIVKAMALAGIEKHVELAKLAHEETKMGVYE
DKITKNLFAVEYVYNYIKDKKTVGILKENLEENYMEVAEPVGVIAGVTPVTNPTSTTMFKCLIAIKTRNPIIFSFHPKAL
KCSIEAAKTMYEAALKAGAPEGCIGWIETPSIEATQLLMTHPDISLILATGGAGMVKAAYSSGKPALGVGPGNVPCYIEK
TANIKRAVSDLILSKTFDNGTVCASEQAVIIDEEIADEVKKLMREYGCYFLNKEETKKLEEFAIDKNTGLMNPAVVGQPA
TKIAEMAGFKVPENTKILVAEYPAVGPEYPLSREKLSPILALYTVKDYNEGIKRCEEMTEFGGLGHSAVIHSENQQIINE
FAKRVRAGRILVNAPASQGAIGDIYNTAIPSLTLGCGTMGRNSTTDNVSVYNLINIKRVFIRKERMKWFRVPPQIYFERG
SLQYLSQVKGKKAFIVTDPVMVKLGFVDKVTYQLDKANIKYEIFSEVEPDPSVDTVEKGVKIMRGFEPDLLIAVGGGSAI
DAAKGMWLFYEYPDTKFEDLRLKFMDIRKRTYRFPELGKKALFIAIPTTSGTGSEVTAFAVITDKKKNIKYPLTDYELTP
DIAIIDPDLTMTIPPSVTADTGMDALTHAIEAYVSVMASDYTDALAEKAIKLIFEYLPKAYKNGQDKVAREKMHNASCIA
GMAFTNAFLGINHSMAHILGAKFHLPHGRANAILLPYVIEYNAELPKKFASFPQYEYPKAAEKYAEIAKFLGLPASTIEE
GVKSLIEAIKNLMKELNLPLTLKEAGINKEEFEKQIMEMSDIAFNDQCTGSNPRMPLVSEIAEIYRKAYGE

Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=388, Percent_Identity=25.5154639175258, Blast_Score=104, Evalue=4e-22,
Organism=Escherichia coli, GI1787493, Length=857, Percent_Identity=50.6417736289382, Blast_Score=864, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=400, Percent_Identity=37.25, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=37.467018469657, Blast_Score=233, Evalue=5e-62,
Organism=Escherichia coli, GI87082107, Length=409, Percent_Identity=35.6968215158924, Blast_Score=229, Evalue=6e-61,
Organism=Escherichia coli, GI1788797, Length=440, Percent_Identity=30.2272727272727, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1789386, Length=376, Percent_Identity=27.1276595744681, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17537053, Length=384, Percent_Identity=24.4791666666667, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=416, Percent_Identity=37.5, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24657991, Length=390, Percent_Identity=27.6923076923077, Blast_Score=113, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 96854; Mature: 96723

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLLQEKKETKEKTEVKETTDVKKQIDLLVERAKRAQEKFMSYTQEQINEIVKAMALAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKHVELAKLAHEETKMGVYEDKITKNLFAVEYVYNYIKDKKTVGILKENLEENYMEVAE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
PVGVIAGVTPVTNPTSTTMFKCLIAIKTRNPIIFSFHPKALKCSIEAAKTMYEAALKAGA
HHHHHCCCCCCCCCCHHHHHHHHHEEECCCCEEEEECCCHHEEHHHHHHHHHHHHHHCCC
PEGCIGWIETPSIEATQLLMTHPDISLILATGGAGMVKAAYSSGKPALGVGPGNVPCYIE
CCCCEECCCCCCCCHHEEEEECCCEEEEEEECCCCHHHHHHCCCCCCEECCCCCCCEEEE
KTANIKRAVSDLILSKTFDNGTVCASEQAVIIDEEIADEVKKLMREYGCYFLNKEETKKL
CCCHHHHHHHHHHHHCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHCCEEECHHHHHHH
EEFAIDKNTGLMNPAVVGQPATKIAEMAGFKVPENTKILVAEYPAVGPEYPLSREKLSPI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHCCE
LALYTVKDYNEGIKRCEEMTEFGGLGHSAVIHSENQQIINEFAKRVRAGRILVNAPASQG
EEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCEEEEECCCCCC
AIGDIYNTAIPSLTLGCGTMGRNSTTDNVSVYNLINIKRVFIRKERMKWFRVPPQIYFER
CCHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHEEEC
GSLQYLSQVKGKKAFIVTDPVMVKLGFVDKVTYQLDKANIKYEIFSEVEPDPSVDTVEKG
CCHHHHHHHCCCEEEEEECCEEEEECCHHHHHHEEECCCCEEEEECCCCCCCCHHHHHHH
VKIMRGFEPDLLIAVGGGSAIDAAKGMWLFYEYPDTKFEDLRLKFMDIRKRTYRFPELGK
HHHHHCCCCCEEEEECCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
KALFIAIPTTSGTGSEVTAFAVITDKKKNIKYPLTDYELTPDIAIIDPDLTMTIPPSVTA
CEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCC
DTGMDALTHAIEAYVSVMASDYTDALAEKAIKLIFEYLPKAYKNGQDKVAREKMHNASCI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
AGMAFTNAFLGINHSMAHILGAKFHLPHGRANAILLPYVIEYNAELPKKFASFPQYEYPK
HHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCH
AAEKYAEIAKFLGLPASTIEEGVKSLIEAIKNLMKELNLPLTLKEAGINKEEFEKQIMEM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHH
SDIAFNDQCTGSNPRMPLVSEIAEIYRKAYGE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTLLQEKKETKEKTEVKETTDVKKQIDLLVERAKRAQEKFMSYTQEQINEIVKAMALAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKHVELAKLAHEETKMGVYEDKITKNLFAVEYVYNYIKDKKTVGILKENLEENYMEVAE
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
PVGVIAGVTPVTNPTSTTMFKCLIAIKTRNPIIFSFHPKALKCSIEAAKTMYEAALKAGA
HHHHHCCCCCCCCCCHHHHHHHHHEEECCCCEEEEECCCHHEEHHHHHHHHHHHHHHCCC
PEGCIGWIETPSIEATQLLMTHPDISLILATGGAGMVKAAYSSGKPALGVGPGNVPCYIE
CCCCEECCCCCCCCHHEEEEECCCEEEEEEECCCCHHHHHHCCCCCCEECCCCCCCEEEE
KTANIKRAVSDLILSKTFDNGTVCASEQAVIIDEEIADEVKKLMREYGCYFLNKEETKKL
CCCHHHHHHHHHHHHCCCCCCCEECCCCEEEECHHHHHHHHHHHHHHCCEEECHHHHHHH
EEFAIDKNTGLMNPAVVGQPATKIAEMAGFKVPENTKILVAEYPAVGPEYPLSREKLSPI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHCCE
LALYTVKDYNEGIKRCEEMTEFGGLGHSAVIHSENQQIINEFAKRVRAGRILVNAPASQG
EEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCEEEEECCCCCC
AIGDIYNTAIPSLTLGCGTMGRNSTTDNVSVYNLINIKRVFIRKERMKWFRVPPQIYFER
CCHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHEEEC
GSLQYLSQVKGKKAFIVTDPVMVKLGFVDKVTYQLDKANIKYEIFSEVEPDPSVDTVEKG
CCHHHHHHHCCCEEEEEECCEEEEECCHHHHHHEEECCCCEEEEECCCCCCCCHHHHHHH
VKIMRGFEPDLLIAVGGGSAIDAAKGMWLFYEYPDTKFEDLRLKFMDIRKRTYRFPELGK
HHHHHCCCCCEEEEECCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
KALFIAIPTTSGTGSEVTAFAVITDKKKNIKYPLTDYELTPDIAIIDPDLTMTIPPSVTA
CEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCC
DTGMDALTHAIEAYVSVMASDYTDALAEKAIKLIFEYLPKAYKNGQDKVAREKMHNASCI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
AGMAFTNAFLGINHSMAHILGAKFHLPHGRANAILLPYVIEYNAELPKKFASFPQYEYPK
HHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCH
AAEKYAEIAKFLGLPASTIEEGVKSLIEAIKNLMKELNLPLTLKEAGINKEEFEKQIMEM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHH
SDIAFNDQCTGSNPRMPLVSEIAEIYRKAYGE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]