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The map label for this gene is ipk

Identifier: 167039258

GI number: 167039258

Start: 623253

End: 624122

Strand: Direct

Name: ipk

Synonym: Teth514_0599

Alternate gene names: 167039258

Gene position: 623253-624122 (Clockwise)

Preceding gene: 167039257

Following gene: 167039259

Centisome position: 25.36

GC content: 32.76

Gene sequence:

>870_bases
ATGAAAAAAATCAAAGTAAAGGCCTATGCAAAAATCAATTTGTCTTTAGACGTGCTAGGTAAGAGAAAAGATGGATATCA
TGAAATTTCTACAGTGATGCAATCAATTGATTTGGCTGATATTTTAGAGTTTGAAAAAAGCGAAATAGTCAAGGTTTTTT
GTAGTGGCCATCGAGTTCCTGAAGGAGAAGATAATTTAATAGTAAAGGTCATCAACTTTTTAAAAGAAAAATATCAAATA
GAAGAAGGAGTGTTAGTCAGGCTTGACAAGAAAATCCCTTTAGCTGCCGGCCTTGCTGGGGGAAGTGCTGATGCTGCTGC
TACAATTGTTGCATTAGACAAATTATGGAATTTAAACATGTCAGCAGATGAGAAAAAAGAAATTGCTTTGAAAGTGGGAG
CAGATGTTCCTTTCTGTCTGGAAGGTGGGACAAAGCTTGCAAAAGGCATAGGGGAAATTTTTGAAGATTTGAATGTTCCT
CATATGAATTTACTTCTTGTAAAACCTGATATTGAAATTTTCACAAAAAAAATTTATGATAAATGGGATAGGCTTAATTT
TAAAAGCCATCATGCTACTTGTTCAGTAGTTCAAGCTATACAGGAAGGAAACATATACAAAATTGCAGAAAATATAAAAA
ATGATTTAGAATTAGTAACTTCTCGGGAATGTGAAGTTATTAATCAAATAAAAGAGGAGTTGCTTAAAAAAGGTGCTTTA
GGATGTGCTATGTCGGGCAGTGGTCCCACTGTTTATGGAATTTTTGACGATTTACAAAAGCTTATAAAAGCCTATAAAAA
TTTAGAAGGAATTTACAGTTTTGTATTTTTTTCAAAAACTATAGATAAGGGGTTAGAATTGTATGAATGA

Upstream 100 bases:

>100_bases
GAGACTGCGTATTTTTTTTACAGAAATTTTATTGTATAATGTATAATAAATGTATAATATATGAAACTATAATTATTATT
GAAAAAGCGAGGATAAAGGA

Downstream 100 bases:

>100_bases
GTTTTTTCCATTGGAAAATTACAAACCGTTAAGAGATGTAGTTTTTGATTACATGAAAGATGCCATAATTACAGGTAAAT
TAAGACCTGGAGAGAGACTT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVPEGEDNLIVKVINFLKEKYQI
EEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNMSADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVP
HMNLLLVKPDIEIFTKKIYDKWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGAL
GCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE

Sequences:

>Translated_289_residues
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVPEGEDNLIVKVINFLKEKYQI
EEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNMSADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVP
HMNLLLVKPDIEIFTKKIYDKWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGAL
GCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE
>Mature_289_residues
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVPEGEDNLIVKVINFLKEKYQI
EEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNMSADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVP
HMNLLLVKPDIEIFTKKIYDKWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGAL
GCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=262, Percent_Identity=27.8625954198473, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_THEPX (B0K474)

Other databases:

- EMBL:   CP000923
- RefSeq:   YP_001662243.1
- ProteinModelPortal:   B0K474
- SMR:   B0K474
- GeneID:   5877475
- GenomeReviews:   CP000923_GR
- KEGG:   tex:Teth514_0599
- HOGENOM:   HBG734593
- OMA:   VSTKEVY
- ProtClustDB:   PRK00128
- BioCyc:   TSP1755:TETH514_0599-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 32214; Mature: 32214

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVP
CCCEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
EGEDNLIVKVINFLKEKYQIEEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNM
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
SADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVPHMNLLLVKPDIEIFTKKIYD
CCCCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
KWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGAL
HHHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
GCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE
CEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCC
>Mature Secondary Structure
MKKIKVKAYAKINLSLDVLGKRKDGYHEISTVMQSIDLADILEFEKSEIVKVFCSGHRVP
CCCEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
EGEDNLIVKVINFLKEKYQIEEGVLVRLDKKIPLAAGLAGGSADAAATIVALDKLWNLNM
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
SADEKKEIALKVGADVPFCLEGGTKLAKGIGEIFEDLNVPHMNLLLVKPDIEIFTKKIYD
CCCCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
KWDRLNFKSHHATCSVVQAIQEGNIYKIAENIKNDLELVTSRECEVINQIKEELLKKGAL
HHHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
GCAMSGSGPTVYGIFDDLQKLIKAYKNLEGIYSFVFFSKTIDKGLELYE
CEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA