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The map label for this gene is yclK [H]

Identifier: 167039248

GI number: 167039248

Start: 610904

End: 612316

Strand: Direct

Name: yclK [H]

Synonym: Teth514_0589

Alternate gene names: 167039248

Gene position: 610904-612316 (Clockwise)

Preceding gene: 167039247

Following gene: 167039249

Centisome position: 24.86

GC content: 32.41

Gene sequence:

>1413_bases
TTGAGCAAAAATAGACTTTTTAAAAAACTTTTTATAAGCAATATGATTATCATCCTTATTACTTTGTCTATTCTTTCAGG
GATGTTTTATCTGATGTTTCAAAACTATTACTTTGCTGACAAAGAAAAAATAATGTTAGAAGAGGCTCAAGAAATAAATG
CAATTTTAAATGAATTTGCGGTAGGAGACATAAACATAGATAAATGGAATCAAGAACTAAACGTTGTTACTAGATTGATT
AATGCTACTGTATGGATCGTAGATAAAGAAGGGCTAATTTACAGTCAATCACAACAGCAGGGCAAAGCATGGACAGGAGT
AAGCCTCAGTAAAGAAGAAATAAAAAGCATTTTAGATGGACAATCTGTTGTAAAAAAAGGATATTTTGGTGGCAAATTCA
ATCAGCCTGTTTTGACAGTAGGAGTGCCTCTTGTTATAAATGGCCGAATTGAAGGTGCTATATTTATGCATGCTCCTTTG
ACAGAAATGAATAAAACTATTATTAACATCTTTATTTTAATGCTTTTATCTGGAGGAGTAGCTCTTATAATAGGTTTTGT
GCTCATTTCTTATACTTCCAGTAAAATATCTCAGCCTCTTAAAGAGATGAGCTTAGCTGTTCAGCAGGTAGCGAAGGGGA
ATTTTTCTGCAAGGGTACAACATAAGGAAGAAGATGAAATAGGGGATTTGGCTAAATCCTTTAATATTATGGCAAAAGAA
TTAGAACAATTAGAAAACATGAGAAAAGATTTTGTGGCAAATGTTTCTCACGAATTGAGGTCTCCATTGACCTCTATACA
AGGATATATAGATGGGATATTAGACGGTACTATTCCAAAGGAAAAAGCTTGCGATTATCTTAAAATAGTACAAAAAGAAA
CACGGAGGATGTCTCGGCTCATAGACGATTTTCTTGAAATGACTAAACTTGAGTCAGGTCAATTTCCACTGCATAAGACG
GAATTTGATATAAATGAACTTATAAGACTGGCCGTTATAAAGTTTGAAAAAAGAATAGTGGAAAAAGATCTAACCGTTAA
AGTTGATTTTGAAGAAGACAGACGAATAGTTATAGGTGATAAGGACAAGATAGAACAAGTTTTGACAAATCTTATAGACA
ATGCAATAAAATTTTCTAAAGAAAAGGGTATAATTCATATTTTTACTGAAATAAAAGATGACAAAGTATTCATTACTATA
AAAGATAATGGAATAGGTATTTCTCCAGAAGACCAAGAGCATATATGGGATAGATTTTATAAAGCGGACAAATCGAGAGG
AAAAGATGGAGCAGGCCTTGGGCTTTATATAGTAAAGCGTATTATAAATGCTCATAACGAGGAAATATGGGTAGAAAGTG
AAGTTGGTAAAGGTACAGCATTTACTTTTACTTTGTCGGTGAAAAAATTTTAA

Upstream 100 bases:

>100_bases
ATGTTCATATAAAGCGGCTTAGAGAGAAAATGGGAGATGGCCCTAATTGGAAACTTACCACCGTATGGGGTGTAGGTTAT
AAATTTGAGGTGAACTAAAT

Downstream 100 bases:

>100_bases
AAAATCACAATAAAATATTTACACTTTGTTAACACTTTATTCATAAATAAGGGATACAATAATATTTGAGAGCGACAAAT
GCCTCTCCTTGACCTCCCTT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSKNRLFKKLFISNMIIILITLSILSGMFYLMFQNYYFADKEKIMLEEAQEINAILNEFAVGDINIDKWNQELNVVTRLI
NATVWIVDKEGLIYSQSQQQGKAWTGVSLSKEEIKSILDGQSVVKKGYFGGKFNQPVLTVGVPLVINGRIEGAIFMHAPL
TEMNKTIINIFILMLLSGGVALIIGFVLISYTSSKISQPLKEMSLAVQQVAKGNFSARVQHKEEDEIGDLAKSFNIMAKE
LEQLENMRKDFVANVSHELRSPLTSIQGYIDGILDGTIPKEKACDYLKIVQKETRRMSRLIDDFLEMTKLESGQFPLHKT
EFDINELIRLAVIKFEKRIVEKDLTVKVDFEEDRRIVIGDKDKIEQVLTNLIDNAIKFSKEKGIIHIFTEIKDDKVFITI
KDNGIGISPEDQEHIWDRFYKADKSRGKDGAGLGLYIVKRIINAHNEEIWVESEVGKGTAFTFTLSVKKF

Sequences:

>Translated_470_residues
MSKNRLFKKLFISNMIIILITLSILSGMFYLMFQNYYFADKEKIMLEEAQEINAILNEFAVGDINIDKWNQELNVVTRLI
NATVWIVDKEGLIYSQSQQQGKAWTGVSLSKEEIKSILDGQSVVKKGYFGGKFNQPVLTVGVPLVINGRIEGAIFMHAPL
TEMNKTIINIFILMLLSGGVALIIGFVLISYTSSKISQPLKEMSLAVQQVAKGNFSARVQHKEEDEIGDLAKSFNIMAKE
LEQLENMRKDFVANVSHELRSPLTSIQGYIDGILDGTIPKEKACDYLKIVQKETRRMSRLIDDFLEMTKLESGQFPLHKT
EFDINELIRLAVIKFEKRIVEKDLTVKVDFEEDRRIVIGDKDKIEQVLTNLIDNAIKFSKEKGIIHIFTEIKDDKVFITI
KDNGIGISPEDQEHIWDRFYKADKSRGKDGAGLGLYIVKRIINAHNEEIWVESEVGKGTAFTFTLSVKKF
>Mature_469_residues
SKNRLFKKLFISNMIIILITLSILSGMFYLMFQNYYFADKEKIMLEEAQEINAILNEFAVGDINIDKWNQELNVVTRLIN
ATVWIVDKEGLIYSQSQQQGKAWTGVSLSKEEIKSILDGQSVVKKGYFGGKFNQPVLTVGVPLVINGRIEGAIFMHAPLT
EMNKTIINIFILMLLSGGVALIIGFVLISYTSSKISQPLKEMSLAVQQVAKGNFSARVQHKEEDEIGDLAKSFNIMAKEL
EQLENMRKDFVANVSHELRSPLTSIQGYIDGILDGTIPKEKACDYLKIVQKETRRMSRLIDDFLEMTKLESGQFPLHKTE
FDINELIRLAVIKFEKRIVEKDLTVKVDFEEDRRIVIGDKDKIEQVLTNLIDNAIKFSKEKGIIHIFTEIKDDKVFITIK
DNGIGISPEDQEHIWDRFYKADKSRGKDGAGLGLYIVKRIINAHNEEIWVESEVGKGTAFTFTLSVKKF

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=30.4029304029304, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=35.042735042735, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1789149, Length=350, Percent_Identity=28.8571428571429, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=25.9259259259259, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=32.0175438596491, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=31.2236286919831, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790346, Length=285, Percent_Identity=29.1228070175439, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=28.6259541984733, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790861, Length=317, Percent_Identity=26.813880126183, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=27.2340425531915, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789808, Length=314, Percent_Identity=27.0700636942675, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=269, Percent_Identity=24.907063197026, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=27.3858921161826, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=27.5862068965517, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=23.7388724035608, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=21.2121212121212, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=219, Percent_Identity=27.8538812785388, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789403, Length=267, Percent_Identity=23.9700374531835, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=243, Percent_Identity=25.5144032921811, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787374, Length=279, Percent_Identity=20.4301075268817, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53490; Mature: 53359

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNRLFKKLFISNMIIILITLSILSGMFYLMFQNYYFADKEKIMLEEAQEINAILNEFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VGDINIDKWNQELNVVTRLINATVWIVDKEGLIYSQSQQQGKAWTGVSLSKEEIKSILDG
CCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEECCCHHCCCCCCCCCCCHHHHHHHHCC
QSVVKKGYFGGKFNQPVLTVGVPLVINGRIEGAIFMHAPLTEMNKTIINIFILMLLSGGV
HHHHHCCCCCCCCCCCEEEECCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCH
ALIIGFVLISYTSSKISQPLKEMSLAVQQVAKGNFSARVQHKEEDEIGDLAKSFNIMAKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
LEQLENMRKDFVANVSHELRSPLTSIQGYIDGILDGTIPKEKACDYLKIVQKETRRMSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IDDFLEMTKLESGQFPLHKTEFDINELIRLAVIKFEKRIVEKDLTVKVDFEEDRRIVIGD
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECC
KDKIEQVLTNLIDNAIKFSKEKGIIHIFTEIKDDKVFITIKDNGIGISPEDQEHIWDRFY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHH
KADKSRGKDGAGLGLYIVKRIINAHNEEIWVESEVGKGTAFTFTLSVKKF
HHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEECC
>Mature Secondary Structure 
SKNRLFKKLFISNMIIILITLSILSGMFYLMFQNYYFADKEKIMLEEAQEINAILNEFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VGDINIDKWNQELNVVTRLINATVWIVDKEGLIYSQSQQQGKAWTGVSLSKEEIKSILDG
CCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEECCCHHCCCCCCCCCCCHHHHHHHHCC
QSVVKKGYFGGKFNQPVLTVGVPLVINGRIEGAIFMHAPLTEMNKTIINIFILMLLSGGV
HHHHHCCCCCCCCCCCEEEECCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCH
ALIIGFVLISYTSSKISQPLKEMSLAVQQVAKGNFSARVQHKEEDEIGDLAKSFNIMAKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHH
LEQLENMRKDFVANVSHELRSPLTSIQGYIDGILDGTIPKEKACDYLKIVQKETRRMSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IDDFLEMTKLESGQFPLHKTEFDINELIRLAVIKFEKRIVEKDLTVKVDFEEDRRIVIGD
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECC
KDKIEQVLTNLIDNAIKFSKEKGIIHIFTEIKDDKVFITIKDNGIGISPEDQEHIWDRFY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHH
KADKSRGKDGAGLGLYIVKRIINAHNEEIWVESEVGKGTAFTFTLSVKKF
HHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]