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The map label for this gene is panB

Identifier: 167039088

GI number: 167039088

Start: 442469

End: 443293

Strand: Reverse

Name: panB

Synonym: Teth514_0427

Alternate gene names: 167039088

Gene position: 443293-442469 (Counterclockwise)

Preceding gene: 167039089

Following gene: 167039087

Centisome position: 18.04

GC content: 39.03

Gene sequence:

>825_bases
ATGGAGGAAAAAGTATCAACTCTCACACTAAGGAAATTTAAGAAAGAAGGAAGAAAGATAACAGCTTTAACTGCTTATGA
CTTCCCCACAGCTAAAATCCTTGACAATTGCGGAATTGACATGATTTTAGTAGGAGATTCTCTCGGGATGGTGGTTTTAG
GATACGAAAGCACAATACCTGTCACAATGGAAGACATGATACATCACACAAAAGCCGTTTCAAGGGCAGTCAATCGTGCA
TTTATAGTTGCTGACATGCCTTTTATGTCATATCACATATCAAAAGAACAGGCTATGACAAATGCTGCAAGGCTTATTGC
AGAAGGCGGAGCCCACGCCGTAAAATTAGAAGGAGGAGAAGAAATAGCTTCAATAGTCAAAGCCATAGTAGACGCAGGAA
TACCAGTGGTAGGTCATCTCGGTCTCACTCCTCAATCAGTCCATCAACTGGGAGGGTATAAAGTCCAAGGCAAAGAAAAG
GAACAAGCAAAAAAGATTTTTAACGATGCCAAAGTATTAGAACAAGCAGGTATATGTGCCCTTGTGCTTGAAAGCATTCC
AATGGAGCTTGCAAAAAACATTACAGAAAATATTTCAGTTCCAACTATTGGAATAGGTGCCGGTCCTTACTGCGATGGTC
AAATCCTTGTCACCCACGACATGCTGGGAATAACTCAAGGTCATAGGCCTAAATTTGTAAAACAATACGCAGATATTGAA
AAAATAATGATTGATGGCATAAATGCTTACATTAAAGAAGTACAACAAGTCTTATTCCCAGATGAAGAACATTCTTTTAC
TTTAGAAAAGAGGGAGAATAAATGA

Upstream 100 bases:

>100_bases
GAAGAGCTTTATAAAAGTTTGGGTAAATTAACTCTTGAGATTGCTTATGAAAAAGGAAGTTTTAACGATGAAAAATATTT
TGAATTGGAGGGTATATTAA

Downstream 100 bases:

>100_bases
TAGTAACAGATAAAATTAGTGATGTAAGAAATATAATTAAAGAACAAAAATTGTCAGGTAAAAAAATTGGACTTGTACCT
ACAATGGGATATTTGCACGA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIPVTMEDMIHHTKAVSRAVNRA
FIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGEEIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEK
EQAKKIFNDAKVLEQAGICALVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIE
KIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK

Sequences:

>Translated_274_residues
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIPVTMEDMIHHTKAVSRAVNRA
FIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGEEIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEK
EQAKKIFNDAKVLEQAGICALVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIE
KIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK
>Mature_274_residues
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIPVTMEDMIHHTKAVSRAVNRA
FIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGEEIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEK
EQAKKIFNDAKVLEQAGICALVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIE
KIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=48.2490272373541, Blast_Score=251, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319653, Length=262, Percent_Identity=37.7862595419847, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_THEP3 (B0KC90)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665780.1
- ProteinModelPortal:   B0KC90
- SMR:   B0KC90
- GeneID:   5874469
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1808
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- ProtClustDB:   PRK00311
- BioCyc:   TPSE340099:TETH39_1808-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 29988; Mature: 29988

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 184-184 BINDING 85-85 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIP
CCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCEEEEECCCCCEEEEECCCCCC
VTMEDMIHHTKAVSRAVNRAFIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGE
EEHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHH
EIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEKEQAKKIFNDAKVLEQAGICA
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHCCHHH
LVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIE
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECHHHCCCCCCHHHHHHHHHHH
KIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
>Mature Secondary Structure
MEEKVSTLTLRKFKKEGRKITALTAYDFPTAKILDNCGIDMILVGDSLGMVVLGYESTIP
CCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCEEEEECCCCCEEEEECCCCCC
VTMEDMIHHTKAVSRAVNRAFIVADMPFMSYHISKEQAMTNAARLIAEGGAHAVKLEGGE
EEHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHH
EIASIVKAIVDAGIPVVGHLGLTPQSVHQLGGYKVQGKEKEQAKKIFNDAKVLEQAGICA
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHCCHHH
LVLESIPMELAKNITENISVPTIGIGAGPYCDGQILVTHDMLGITQGHRPKFVKQYADIE
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECHHHCCCCCCHHHHHHHHHHH
KIMIDGINAYIKEVQQVLFPDEEHSFTLEKRENK
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA