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The map label for this gene is yugH [H]

Identifier: 167038855

GI number: 167038855

Start: 188052

End: 189218

Strand: Reverse

Name: yugH [H]

Synonym: Teth514_0185

Alternate gene names: 167038855

Gene position: 189218-188052 (Counterclockwise)

Preceding gene: 167038856

Following gene: 167038820

Centisome position: 7.7

GC content: 35.56

Gene sequence:

>1167_bases
ATGAATACAGACAAATACATATCCAACGTAGTAAAAAGTATTCCACCGTCCGGAATCAGAAAATTTTTTGACCTTGTGAC
TAATTCAAAAGACATAATATCACTGGGAGTTGGCGAACCAGATTTTGTAACTCCGTGGGAAATAAGAAAAGAAGGCATTA
ACGCACTAGATAGAGGTAGCACAACATACACCTCAAACTTAGGCTTGCCCGAACTTAGAATGGCCATATCCTATTTCTTA
AAAACTCATTATAATTTAACCTATGACCCTGAAAAAGAAATAATGGTAACTATTGGTGCTAGTGAAGCCATTGACCTTGC
TCTGCGAGCTCTTTTAAATGACGGTGACGAAGTCTTAGTTCCTGAACCTAGCTATGTTTCATATGCCCCCTGTGTAACTT
TGACAAGAGGCATCCCTGTATTTGTTCCTACTGATGAAAAAAACAATTTTATACTAACCCCTGATGACCTAAAATCAAAA
ATAACCTCGAAAACAAAAGCATTAATTCTTCCTTACCCCAATAACCCTACAGGTGCTATCATGAAAAAAGAAGAATTAGA
AGAAATTGTAAACATAATAATCGAGCATGATTTAATAGTAATTTCTGATGAAATATATAGTGAATTGACTTATGAAGGAA
GACACGTAAGCATAGCCTCACTTCCGGGCATGAAAGAAAGGACAATACTTATAAACGGTTTTTCTAAAGCTTTTGCCATG
ACAGGTTGGAGACTTGGATATATTGCAGCAGAACACGGATTCATTGAAGCGATGAATAAAATCCATCAGTACACAACTAT
ATGCGCTCCAATAACAGCACAATATGCAGCTATAAAGGGTATATATCAATGTGAAGAAGACATAGTAAAAATGAGAGAAA
CATATGATAAGAGAAGGAAATTTATTGTAAACGGATTTCGCGAAATAGGTTTTGACTGCTTTGAGCCAAAAGGAGCTTTC
TATATTTTCCCGTCAATAAAAAAGACGGGTATGACTTCACAGGAATTTTGTGAAAAACTCTTAAAAGAAGAAAAAGTAGC
TGTAGTACCAGGAGACGCATTTGGCCCAAGCGGTGAAGGATTTATTCGTGTATCATACGCATATTCTATAGATAAAATAG
CAAGAGCACTTGAAAGAATAAAAAATTTTGCAAAGAGAATATTGTAA

Upstream 100 bases:

>100_bases
GCGTATTAAGCACTACCACACATTTTATTTTAAAAAGATATAAAAAAGACGGAGTTTTTTATGAAGAAGGACAAGACGAC
AAAAGATTGGTGATAACACC

Downstream 100 bases:

>100_bases
AGGAATAACATCCAACATATCGCAAAATACCTTTAATGTAAAAAGGAATCCTTACATCGAAAGGATTCCTTAAACTTTGT
ATGGCAATTAAGCTTCTTGG

Product: class I and II aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNTDKYISNVVKSIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGINALDRGSTTYTSNLGLPELRMAISYFL
KTHYNLTYDPEKEIMVTIGASEAIDLALRALLNDGDEVLVPEPSYVSYAPCVTLTRGIPVFVPTDEKNNFILTPDDLKSK
ITSKTKALILPYPNNPTGAIMKKEELEEIVNIIIEHDLIVISDEIYSELTYEGRHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHGFIEAMNKIHQYTTICAPITAQYAAIKGIYQCEEDIVKMRETYDKRRKFIVNGFREIGFDCFEPKGAF
YIFPSIKKTGMTSQEFCEKLLKEEKVAVVPGDAFGPSGEGFIRVSYAYSIDKIARALERIKNFAKRIL

Sequences:

>Translated_388_residues
MNTDKYISNVVKSIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGINALDRGSTTYTSNLGLPELRMAISYFL
KTHYNLTYDPEKEIMVTIGASEAIDLALRALLNDGDEVLVPEPSYVSYAPCVTLTRGIPVFVPTDEKNNFILTPDDLKSK
ITSKTKALILPYPNNPTGAIMKKEELEEIVNIIIEHDLIVISDEIYSELTYEGRHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHGFIEAMNKIHQYTTICAPITAQYAAIKGIYQCEEDIVKMRETYDKRRKFIVNGFREIGFDCFEPKGAF
YIFPSIKKTGMTSQEFCEKLLKEEKVAVVPGDAFGPSGEGFIRVSYAYSIDKIARALERIKNFAKRIL
>Mature_388_residues
MNTDKYISNVVKSIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGINALDRGSTTYTSNLGLPELRMAISYFL
KTHYNLTYDPEKEIMVTIGASEAIDLALRALLNDGDEVLVPEPSYVSYAPCVTLTRGIPVFVPTDEKNNFILTPDDLKSK
ITSKTKALILPYPNNPTGAIMKKEELEEIVNIIIEHDLIVISDEIYSELTYEGRHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHGFIEAMNKIHQYTTICAPITAQYAAIKGIYQCEEDIVKMRETYDKRRKFIVNGFREIGFDCFEPKGAF
YIFPSIKKTGMTSQEFCEKLLKEEKVAVVPGDAFGPSGEGFIRVSYAYSIDKIARALERIKNFAKRIL

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=390, Percent_Identity=31.5384615384615, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI56713256, Length=390, Percent_Identity=31.5384615384615, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI95147551, Length=323, Percent_Identity=31.2693498452012, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI169881279, Length=323, Percent_Identity=31.2693498452012, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI169881281, Length=228, Percent_Identity=32.0175438596491, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4507369, Length=393, Percent_Identity=25.9541984732824, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI19263340, Length=367, Percent_Identity=23.7057220708447, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI215599424, Length=367, Percent_Identity=23.7057220708447, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI187936925, Length=395, Percent_Identity=23.5443037974684, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI14211921, Length=395, Percent_Identity=23.5443037974684, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI7705897, Length=409, Percent_Identity=22.7383863080685, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI33469970, Length=409, Percent_Identity=22.7383863080685, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788722, Length=383, Percent_Identity=31.8537859007833, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786816, Length=362, Percent_Identity=27.9005524861878, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788627, Length=398, Percent_Identity=31.6582914572864, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790797, Length=313, Percent_Identity=26.1980830670927, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787710, Length=238, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788332, Length=226, Percent_Identity=27.4336283185841, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=406, Percent_Identity=29.8029556650246, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71994472, Length=406, Percent_Identity=29.8029556650246, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17567369, Length=393, Percent_Identity=27.9898218829517, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17567663, Length=382, Percent_Identity=29.5811518324607, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322401, Length=386, Percent_Identity=28.4974093264249, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323118, Length=370, Percent_Identity=24.8648648648649, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320317, Length=341, Percent_Identity=25.2199413489736, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28573069, Length=408, Percent_Identity=26.4705882352941, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646114, Length=408, Percent_Identity=26.4705882352941, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28573067, Length=408, Percent_Identity=26.4705882352941, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28573065, Length=408, Percent_Identity=26.4705882352941, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI18859735, Length=420, Percent_Identity=25.4761904761905, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45551451, Length=396, Percent_Identity=22.4747474747475, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24641770, Length=396, Percent_Identity=22.4747474747475, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641760, Length=396, Percent_Identity=22.4747474747475, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641768, Length=396, Percent_Identity=22.4747474747475, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641766, Length=396, Percent_Identity=22.4747474747475, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641764, Length=396, Percent_Identity=22.4747474747475, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 43624; Mature: 43624

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDKYISNVVKSIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGINALDRGS
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHCCC
TTYTSNLGLPELRMAISYFLKTHYNLTYDPEKEIMVTIGASEAIDLALRALLNDGDEVLV
CEEECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEEE
PEPSYVSYAPCVTLTRGIPVFVPTDEKNNFILTPDDLKSKITSKTKALILPYPNNPTGAI
CCCCCCCCCCHHHHHCCCEEEEECCCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCCCC
MKKEELEEIVNIIIEHDLIVISDEIYSELTYEGRHVSIASLPGMKERTILINGFSKAFAM
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCHHHHHH
TGWRLGYIAAEHGFIEAMNKIHQYTTICAPITAQYAAIKGIYQCEEDIVKMRETYDKRRK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVNGFREIGFDCFEPKGAFYIFPSIKKTGMTSQEFCEKLLKEEKVAVVPGDAFGPSGEG
HHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
FIRVSYAYSIDKIARALERIKNFAKRIL
EEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTDKYISNVVKSIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGINALDRGS
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHCCC
TTYTSNLGLPELRMAISYFLKTHYNLTYDPEKEIMVTIGASEAIDLALRALLNDGDEVLV
CEEECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEEE
PEPSYVSYAPCVTLTRGIPVFVPTDEKNNFILTPDDLKSKITSKTKALILPYPNNPTGAI
CCCCCCCCCCHHHHHCCCEEEEECCCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCCCC
MKKEELEEIVNIIIEHDLIVISDEIYSELTYEGRHVSIASLPGMKERTILINGFSKAFAM
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCHHHHHH
TGWRLGYIAAEHGFIEAMNKIHQYTTICAPITAQYAAIKGIYQCEEDIVKMRETYDKRRK
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVNGFREIGFDCFEPKGAFYIFPSIKKTGMTSQEFCEKLLKEEKVAVVPGDAFGPSGEG
HHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
FIRVSYAYSIDKIARALERIKNFAKRIL
EEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]