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The map label for this gene is serA [H]

Identifier: 167038801

GI number: 167038801

Start: 124393

End: 125355

Strand: Direct

Name: serA [H]

Synonym: Teth514_0128

Alternate gene names: 167038801

Gene position: 124393-125355 (Clockwise)

Preceding gene: 167038800

Following gene: 167038802

Centisome position: 5.06

GC content: 38.01

Gene sequence:

>963_bases
ATGTCTAAGTATAAAGTTGTGATTACTGCTAGATCGTTTGGTGAGAGCAGTGATGAGCCGTTCAATATATTAAAAGGGAA
TGACTGTGAAGTGGTTAAGATTCCTGTTGATAGGCCTTTAAGTGCAGAAGAACTTATACCTTTAGTGAAAGATGCTGATG
CACTGATAGTAGGTAACGATAAAGTAACTGAAGATGTAATTAATGCAGGCAAGAAGTTGAAGGTTATTTCTCGATACGGG
GTTGGATATGATAATGTTGATTTGAATGCTGCAAAGAAAAAAGGAATTGTTGTAACAAATACTCCAAACGCTAATAATAA
CTCCGTGGCTGATTTGGTAATTGGGCTCATGCTCGTGCTTGCAAGGAATTTACTTGCTGTAGATAGAATTGTGAAATCTG
GCGGATGGAAGAGAATAATGGGTACTGAAATCTACGGAAAGACTCTGGGCATAATTGGCTTAGGAAAGATAGGGAAAGGT
GTTGCAAAGAGAGCTAAGGGTTTTGATATGAATGTACTTTGCTATGATGTTTATCCAGATCTAAAATTTTCAGAAGAATA
TGGAGTAACTTATTGCTCATTTGAGGAACTTTTGAAGCAGTCAGATATTGTAACTATCCATGTTCCATTGACACCGGAGA
CAAAAGGTCTTATTGGCGAAAGAGAACTTGGCATGATGAAACCAACTGCTTTCTTGATAAATACATCAAGAGGTGGTATT
GTAGATGAACGCGCACTATACAATGCTTTAGCGAATAAGAAAATAGCAGGGGCTGCACTTGACGTTATGGAACAAGAGCC
ACCCATTAATAGCCCACTTCTTCAGCTTGACAATGTTGTAATAACATCCCATATTGGAGGATACACATGTGAGGCCATTA
CTAATATGGGAATTGTGGCTGCAAAAAATGTTGTACTAGTGTTAAATAAAAAGCAAGGCGCACACATAGTTAATGGCGAA
TAA

Upstream 100 bases:

>100_bases
GCTGAGTGGTAATATTATTAAGCAGTAAATAACGCATATATCGGATAATTAAAAAGCAATTTAAACAGTAAATAACATTG
GATTTTCAAGGGGTGATACA

Downstream 100 bases:

>100_bases
TTTTTAGGAGGGAATGATTATGAAAAGCTATGAGGTATTAAATAAGATTAAGGAAGTAGGAATTTGTGCAATTGTAAGGG
GTACATCCGTTGATTCATTA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSKYKVVITARSFGESSDEPFNILKGNDCEVVKIPVDRPLSAEELIPLVKDADALIVGNDKVTEDVINAGKKLKVISRYG
VGYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVLARNLLAVDRIVKSGGWKRIMGTEIYGKTLGIIGLGKIGKG
VAKRAKGFDMNVLCYDVYPDLKFSEEYGVTYCSFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPTAFLINTSRGGI
VDERALYNALANKKIAGAALDVMEQEPPINSPLLQLDNVVITSHIGGYTCEAITNMGIVAAKNVVLVLNKKQGAHIVNGE

Sequences:

>Translated_320_residues
MSKYKVVITARSFGESSDEPFNILKGNDCEVVKIPVDRPLSAEELIPLVKDADALIVGNDKVTEDVINAGKKLKVISRYG
VGYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVLARNLLAVDRIVKSGGWKRIMGTEIYGKTLGIIGLGKIGKG
VAKRAKGFDMNVLCYDVYPDLKFSEEYGVTYCSFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPTAFLINTSRGGI
VDERALYNALANKKIAGAALDVMEQEPPINSPLLQLDNVVITSHIGGYTCEAITNMGIVAAKNVVLVLNKKQGAHIVNGE
>Mature_319_residues
SKYKVVITARSFGESSDEPFNILKGNDCEVVKIPVDRPLSAEELIPLVKDADALIVGNDKVTEDVINAGKKLKVISRYGV
GYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVLARNLLAVDRIVKSGGWKRIMGTEIYGKTLGIIGLGKIGKGV
AKRAKGFDMNVLCYDVYPDLKFSEEYGVTYCSFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPTAFLINTSRGGIV
DERALYNALANKKIAGAALDVMEQEPPINSPLLQLDNVVITSHIGGYTCEAITNMGIVAAKNVVLVLNKKQGAHIVNGE

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=43.6619718309859, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI6912396, Length=310, Percent_Identity=38.0645161290323, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI4557497, Length=307, Percent_Identity=35.1791530944625, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI61743967, Length=307, Percent_Identity=35.1791530944625, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI145580578, Length=307, Percent_Identity=34.8534201954397, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI4557499, Length=307, Percent_Identity=34.8534201954397, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI145580575, Length=307, Percent_Identity=34.8534201954397, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789279, Length=274, Percent_Identity=41.970802919708, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=38.1944444444444, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=33.7078651685393, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=32.9588014981273, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=238, Percent_Identity=26.890756302521, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=292, Percent_Identity=37.6712328767123, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25147481, Length=342, Percent_Identity=28.3625730994152, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=295, Percent_Identity=37.6271186440678, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=37.6271186440678, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=36.7768595041322, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324964, Length=283, Percent_Identity=30.3886925795053, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=26.6187050359712, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=167, Percent_Identity=29.3413173652695, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19921140, Length=281, Percent_Identity=38.0782918149466, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28571528, Length=317, Percent_Identity=36.5930599369085, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=35.5769230769231, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552429, Length=312, Percent_Identity=33.974358974359, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24585514, Length=312, Percent_Identity=33.974358974359, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574282, Length=312, Percent_Identity=33.974358974359, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI45551003, Length=312, Percent_Identity=33.974358974359, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574284, Length=312, Percent_Identity=33.974358974359, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24585516, Length=275, Percent_Identity=33.4545454545455, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=36.5758754863813, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=36.5758754863813, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=36.5758754863813, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=36.5758754863813, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=36.5758754863813, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34544; Mature: 34412

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYKVVITARSFGESSDEPFNILKGNDCEVVKIPVDRPLSAEELIPLVKDADALIVGND
CCCEEEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECCC
KVTEDVINAGKKLKVISRYGVGYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHH
ARNLLAVDRIVKSGGWKRIMGTEIYGKTLGIIGLGKIGKGVAKRAKGFDMNVLCYDVYPD
HHHHHHHHHHHHCCCCEEEECCEECCCEECEEEECHHHHHHHHHHCCCCCEEEEEECCCC
LKFSEEYGVTYCSFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPTAFLINTSRGGI
CEECHHHCCEEECHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
VDERALYNALANKKIAGAALDVMEQEPPINSPLLQLDNVVITSHIGGYTCEAITNMGIVA
CHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCEEHHHHHCCCEEE
AKNVVLVLNKKQGAHIVNGE
ECCEEEEEECCCCCEECCCC
>Mature Secondary Structure 
SKYKVVITARSFGESSDEPFNILKGNDCEVVKIPVDRPLSAEELIPLVKDADALIVGND
CCEEEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECCC
KVTEDVINAGKKLKVISRYGVGYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHHHH
ARNLLAVDRIVKSGGWKRIMGTEIYGKTLGIIGLGKIGKGVAKRAKGFDMNVLCYDVYPD
HHHHHHHHHHHHCCCCEEEECCEECCCEECEEEECHHHHHHHHHHCCCCCEEEEEECCCC
LKFSEEYGVTYCSFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPTAFLINTSRGGI
CEECHHHCCEEECHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
VDERALYNALANKKIAGAALDVMEQEPPINSPLLQLDNVVITSHIGGYTCEAITNMGIVA
CHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCEEHHHHHCCCEEE
AKNVVLVLNKKQGAHIVNGE
ECCEEEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]