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The map label for this gene is serA [H]

Identifier: 167038797

GI number: 167038797

Start: 120618

End: 121577

Strand: Direct

Name: serA [H]

Synonym: Teth514_0124

Alternate gene names: 167038797

Gene position: 120618-121577 (Clockwise)

Preceding gene: 167038796

Following gene: 167038798

Centisome position: 4.91

GC content: 33.23

Gene sequence:

>960_bases
ATGAAAAAATGGAAAGTTGTTAGTACAGCAGTTACATTTGGAAAAATTAATAAAGAACCAGTAAAACGTCTCGAAGAATT
TGGTTGTGAAGTTGTACTTAATCCTTTTGGAAGACCTTTTACAAATGAAGAAATAATAAGATATGCTTCTGATGCGGATG
CACTGATAGTAGGAAATGATAAAGTTCCAGGGGATGTTATCAAAAAATGTAAGAAACTCAAGATTATTGCAAAACATGGA
GTAGGAGTAGATAGCATCGACGTTAAAACTGCGAATCAATTAGGCATTGTTGTTACTAATGCCCCTGGCACTAACAGCGA
AGAAGTTGCTGATTTAGCTTTTGGATTACTTCATATGCTTGCTCGTGGGCTTTATCAAGCAAATACTGATACAAAAAATG
GCAAGTGGATTAAGCCAGTTGGTATAAGTTTAAGCAAAAAAACTATTGGAATTATCGGAGTTGGTACAATAGGTACTGCA
GTGGCAAAACGAGCTACTGGATATGATATGAATATTTTAGGATATGATATCAAGAAAAATCCATTAGCCTTGGAGCTAGG
AGTAAAGTATGTGGGGCTAGATGAACTTTTATCAGAAGCAGATTTTATAAGTTTGCATTTACCATTAACCAACGATACAT
TAAATATTCTTAATGCAGATAAATTTAAATTAATAAAAAAAGGTGCTATTATGATTAATACTGCTAGGAGTCAACTTATT
GATAATGAAGCTCTTTACAACTCTTTGATAGATGGAACTTTAAAGGGGTATGCTACTGATGTATATGATTTTGAACCTCC
AATGCATTTGCCTCTTTTTGATTTACCTAATGTTATATTAACACCTCATATTGGTGGAACAACTGTTGAATCAAATAAAC
GAATGGGTAATACTGCTGTTGATAATGTAATTGCAGTTTTAAAAGGCGAAACTCCTCCTAATATTGTTTTGGTTGATTAG

Upstream 100 bases:

>100_bases
AGTTGATAGTTTATTCTTGTTTGGTACTATAATTTGTTGATGTGAATCATAATAATGAATATAGGCAGATCTGTTTGTGA
GACGAGGGAGGAATATTTAA

Downstream 100 bases:

>100_bases
AGCTAAGCTAAAGTAAATGAGGGGAGATATTAAATGCCTAGTATAAAAAAAGCAATTCTTTTAAATAAAGCGGATAGTGT
TGCAACGGCATTGTCACAGA

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKKWKVVSTAVTFGKINKEPVKRLEEFGCEVVLNPFGRPFTNEEIIRYASDADALIVGNDKVPGDVIKKCKKLKIIAKHG
VGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGLLHMLARGLYQANTDTKNGKWIKPVGISLSKKTIGIIGVGTIGTA
VAKRATGYDMNILGYDIKKNPLALELGVKYVGLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTARSQLI
DNEALYNSLIDGTLKGYATDVYDFEPPMHLPLFDLPNVILTPHIGGTTVESNKRMGNTAVDNVIAVLKGETPPNIVLVD

Sequences:

>Translated_319_residues
MKKWKVVSTAVTFGKINKEPVKRLEEFGCEVVLNPFGRPFTNEEIIRYASDADALIVGNDKVPGDVIKKCKKLKIIAKHG
VGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGLLHMLARGLYQANTDTKNGKWIKPVGISLSKKTIGIIGVGTIGTA
VAKRATGYDMNILGYDIKKNPLALELGVKYVGLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTARSQLI
DNEALYNSLIDGTLKGYATDVYDFEPPMHLPLFDLPNVILTPHIGGTTVESNKRMGNTAVDNVIAVLKGETPPNIVLVD
>Mature_319_residues
MKKWKVVSTAVTFGKINKEPVKRLEEFGCEVVLNPFGRPFTNEEIIRYASDADALIVGNDKVPGDVIKKCKKLKIIAKHG
VGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGLLHMLARGLYQANTDTKNGKWIKPVGISLSKKTIGIIGVGTIGTA
VAKRATGYDMNILGYDIKKNPLALELGVKYVGLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTARSQLI
DNEALYNSLIDGTLKGYATDVYDFEPPMHLPLFDLPNVILTPHIGGTTVESNKRMGNTAVDNVIAVLKGETPPNIVLVD

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=299, Percent_Identity=36.4548494983278, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=34.469696969697, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=264, Percent_Identity=34.469696969697, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI6912396, Length=296, Percent_Identity=31.4189189189189, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI145580578, Length=262, Percent_Identity=32.824427480916, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI4557499, Length=262, Percent_Identity=32.824427480916, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=32.824427480916, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI87082289, Length=306, Percent_Identity=33.6601307189542, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787645, Length=309, Percent_Identity=32.0388349514563, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=37.6569037656904, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1788660, Length=268, Percent_Identity=30.5970149253731, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081824, Length=229, Percent_Identity=25.764192139738, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=299, Percent_Identity=33.1103678929766, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=34.5195729537367, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=297, Percent_Identity=32.6599326599327, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=297, Percent_Identity=31.986531986532, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=29.9212598425197, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=310, Percent_Identity=25.4838709677419, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=25.6544502617801, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=34.0983606557377, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=32.4232081911263, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585516, Length=281, Percent_Identity=27.7580071174377, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI45552429, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574284, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=33.976833976834, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=33.976833976834, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=33.976833976834, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=33.976833976834, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=33.976833976834, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28574286, Length=297, Percent_Identity=31.3131313131313, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34550; Mature: 34550

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWKVVSTAVTFGKINKEPVKRLEEFGCEVVLNPFGRPFTNEEIIRYASDADALIVGND
CCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHEECCCCCEEEEECC
KVPGDVIKKCKKLKIIAKHGVGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGLLHML
CCCHHHHHHHHHEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ARGLYQANTDTKNGKWIKPVGISLSKKTIGIIGVGTIGTAVAKRATGYDMNILGYDIKKN
HHHHHHCCCCCCCCCEEEECCCEECCCEEEEEEECHHHHHHHHHCCCCCEEEEEEECCCC
PLALELGVKYVGLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTARSQLI
CEEEEECCEEECHHHHHCCCCEEEEEEEECCCCEEECCCHHHHHHHCCEEEEECHHHHHH
DNEALYNSLIDGTLKGYATDVYDFEPPMHLPLFDLPNVILTPHIGGTTVESNKRMGNTAV
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCCCCCCHHH
DNVIAVLKGETPPNIVLVD
HHEEEEEECCCCCCEEEEC
>Mature Secondary Structure
MKKWKVVSTAVTFGKINKEPVKRLEEFGCEVVLNPFGRPFTNEEIIRYASDADALIVGND
CCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHEECCCCCEEEEECC
KVPGDVIKKCKKLKIIAKHGVGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGLLHML
CCCHHHHHHHHHEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHH
ARGLYQANTDTKNGKWIKPVGISLSKKTIGIIGVGTIGTAVAKRATGYDMNILGYDIKKN
HHHHHHCCCCCCCCCEEEECCCEECCCEEEEEEECHHHHHHHHHCCCCCEEEEEEECCCC
PLALELGVKYVGLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTARSQLI
CEEEEECCEEECHHHHHCCCCEEEEEEEECCCCEEECCCHHHHHHHCCEEEEECHHHHHH
DNEALYNSLIDGTLKGYATDVYDFEPPMHLPLFDLPNVILTPHIGGTTVESNKRMGNTAV
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCCCCCCHHH
DNVIAVLKGETPPNIVLVD
HHEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]