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The map label for this gene is holB [H]

Identifier: 167038730

GI number: 167038730

Start: 58399

End: 59373

Strand: Direct

Name: holB [H]

Synonym: Teth514_0056

Alternate gene names: 167038730

Gene position: 58399-59373 (Clockwise)

Preceding gene: 167038729

Following gene: 167038731

Centisome position: 2.38

GC content: 28.51

Gene sequence:

>975_bases
GTGTATAGGATTTATGGGCATGAAACAGTATTAAATATTTTTAAAAATGTAATATCTCAAAATAAAATTTCAAATGCTTA
TTTGTTTGTAGGAGAAGAAGGATTAGGGAAAAGATTTATGGCAGAGTATTTTGCCATGATGATAAATTGTAAAGGGGAAA
CTGCAAAGCCTTGTTTTAAGTGTAGTTCTTGCTTAAAGGTAATGGATAAAAATCATCCAGACGTATTTTTTATAAAGCCG
GAGGAGAATTCTATAAAAGTAGATACTATAAGATATATAACTAATGAAATCAATATAAGACCTTATGAAGCTAACAAAAA
GATTTTTATTATAGACCAAGCTGATAAAATGACTGCAGCAGCTCAAAATGCTTTTCTCAAAACTTTAGAAGAACCTCCCT
TATATGGCCTTTTTATATTGATTGCATCACAACAACAAGAGCTTTTGCCTACAATTGTCTCTCGCTGTAATATAGTCCGT
TTTAATAAGGAAAATAGAAATACGATAAAGAACTATTTAATGTTTGAACACGATATCTCTGAAAAAGAGGCGGAAGTGTT
AGCTCATATTGCTGATGGAAATTTTGCTCAAGCCAACAAATTAACTAATAACGAATATTTAAATTTTAGAAGAGAGACAA
TACAAGAAATAGAAAAAATTCTTACGATTAAAGGATTTGAAGTGATAGAGGAGTTTGAATTTTTTGATAAGAATAAAGAC
AATATAGAAGAAATTTTAAAGATTCTGCTTTCTTATATGAGAGATTTGTTAGTTTTTAAGGCTACAAAAGATGCCTCTTT
TATAAAAAATATAGATTTTTTAAATAGGATACAGGAAATGGAATCCCGATTGACTATTAATAAGCTCAATAATATAATTA
ATAGAATAGAGCAGTTTAATTCACAGATTAATTCAAATATAAACTATCAATTGGCAGTAGAGAATCTATTTTTAGATATG
GCGGGAGGTTTATAA

Upstream 100 bases:

>100_bases
TTACAGAAGAGTTTTTAAAAGATTCCAAACACTTGGAACTTTTAAAAATGATAGATGATATAAGAGGATTATTAATAGAT
ATATATTCATAGGTGATAGC

Downstream 100 bases:

>100_bases
TTTTGGTTATTGTTGTAGGTGTGAGATTTAAAAAAGCAGGGAAGATATACTATTTTGACCCAGGGGATTTGCCAATAAAA
GTAGGAGATAAAGTTATAGT

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MYRIYGHETVLNIFKNVISQNKISNAYLFVGEEGLGKRFMAEYFAMMINCKGETAKPCFKCSSCLKVMDKNHPDVFFIKP
EENSIKVDTIRYITNEINIRPYEANKKIFIIDQADKMTAAAQNAFLKTLEEPPLYGLFILIASQQQELLPTIVSRCNIVR
FNKENRNTIKNYLMFEHDISEKEAEVLAHIADGNFAQANKLTNNEYLNFRRETIQEIEKILTIKGFEVIEEFEFFDKNKD
NIEEILKILLSYMRDLLVFKATKDASFIKNIDFLNRIQEMESRLTINKLNNIINRIEQFNSQINSNINYQLAVENLFLDM
AGGL

Sequences:

>Translated_324_residues
MYRIYGHETVLNIFKNVISQNKISNAYLFVGEEGLGKRFMAEYFAMMINCKGETAKPCFKCSSCLKVMDKNHPDVFFIKP
EENSIKVDTIRYITNEINIRPYEANKKIFIIDQADKMTAAAQNAFLKTLEEPPLYGLFILIASQQQELLPTIVSRCNIVR
FNKENRNTIKNYLMFEHDISEKEAEVLAHIADGNFAQANKLTNNEYLNFRRETIQEIEKILTIKGFEVIEEFEFFDKNKD
NIEEILKILLSYMRDLLVFKATKDASFIKNIDFLNRIQEMESRLTINKLNNIINRIEQFNSQINSNINYQLAVENLFLDM
AGGL
>Mature_324_residues
MYRIYGHETVLNIFKNVISQNKISNAYLFVGEEGLGKRFMAEYFAMMINCKGETAKPCFKCSSCLKVMDKNHPDVFFIKP
EENSIKVDTIRYITNEINIRPYEANKKIFIIDQADKMTAAAQNAFLKTLEEPPLYGLFILIASQQQELLPTIVSRCNIVR
FNKENRNTIKNYLMFEHDISEKEAEVLAHIADGNFAQANKLTNNEYLNFRRETIQEIEKILTIKGFEVIEEFEFFDKNKD
NIEEILKILLSYMRDLLVFKATKDASFIKNIDFLNRIQEMESRLTINKLNNIINRIEQFNSQINSNINYQLAVENLFLDM
AGGL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=207, Percent_Identity=32.8502415458937, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787341, Length=304, Percent_Identity=23.3552631578947, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37758; Mature: 37758

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRIYGHETVLNIFKNVISQNKISNAYLFVGEEGLGKRFMAEYFAMMINCKGETAKPCFK
CEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
CSSCLKVMDKNHPDVFFIKPEENSIKVDTIRYITNEINIRPYEANKKIFIIDQADKMTAA
HHHHHHHHCCCCCCEEEEECCCCCEEEHHHHEEHHHCEEEEEECCCEEEEEECCHHHHHH
AQNAFLKTLEEPPLYGLFILIASQQQELLPTIVSRCNIVRFNKENRNTIKNYLMFEHDIS
HHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCC
EKEAEVLAHIADGNFAQANKLTNNEYLNFRRETIQEIEKILTIKGFEVIEEFEFFDKNKD
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NIEEILKILLSYMRDLLVFKATKDASFIKNIDFLNRIQEMESRLTINKLNNIINRIEQFN
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQINSNINYQLAVENLFLDMAGGL
HHHCCCCCEEEEHHHHHHHHCCCC
>Mature Secondary Structure
MYRIYGHETVLNIFKNVISQNKISNAYLFVGEEGLGKRFMAEYFAMMINCKGETAKPCFK
CEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
CSSCLKVMDKNHPDVFFIKPEENSIKVDTIRYITNEINIRPYEANKKIFIIDQADKMTAA
HHHHHHHHCCCCCCEEEEECCCCCEEEHHHHEEHHHCEEEEEECCCEEEEEECCHHHHHH
AQNAFLKTLEEPPLYGLFILIASQQQELLPTIVSRCNIVRFNKENRNTIKNYLMFEHDIS
HHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCC
EKEAEVLAHIADGNFAQANKLTNNEYLNFRRETIQEIEKILTIKGFEVIEEFEFFDKNKD
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NIEEILKILLSYMRDLLVFKATKDASFIKNIDFLNRIQEMESRLTINKLNNIINRIEQFN
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQINSNINYQLAVENLFLDMAGGL
HHHCCCCCEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]