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The map label for this gene is ribBA [H]

Identifier: 167038697

GI number: 167038697

Start: 25928

End: 27118

Strand: Direct

Name: ribBA [H]

Synonym: Teth514_0022

Alternate gene names: 167038697

Gene position: 25928-27118 (Clockwise)

Preceding gene: 167038696

Following gene: 167038698

Centisome position: 1.06

GC content: 36.19

Gene sequence:

>1191_bases
ATGTTTGATAGGATAGAAGATGCAATAGAAGATATAAAGCAAGGGAAAATGATTATTGTGGTAGATGATGAAAATAGGGA
AAATGAAGGCGACTTAGTTATGGCAGCAGAAAAAGTTACAGGAGAACACATTAATTTTATGATAAAATATGGACGGGGTC
TTGTATGTGTTCCGATGACAGAAAAGAGACTTAATGAGCTTGGCATTTACCAGATGGTTGAGAATAATACTGACCATAAA
GAAACTGCTTTTACTGTATCTGTAGATTATAAAGAATGTACCACTGGTATTTCTGCATTTGAAAGAGCGCTGACAGTGAA
GAAATTAGTAGACGATAATTCAAAGCCGGAAGATTTTACAAAGCCAGGACATATCTTTCCTTTAAGAGCCAAAGATGGTG
GTGTATTAGTAAGGGCAGGGCATACAGAAGCGGCTGTAGACCTTGCAGTTCTTGCAGGACTCAAACCCGCTGGAGTAATA
TGCGAAATCATAAAAGACGATGGAAATATGGCAAGGTTGCCTGACCTTTTAGAGTTTGCAAAAAAATTTGGATTAAGAAT
CATATCTATTGAAGATTTGATAAAGTACAGAATGAAAAATGAAATACTTGTGAGAAGGGTAGCACAGGCGAAACTTCCAA
CGAAGTATGGAAATTTTGAAATTGTTGGATATGAAGAAATATTAACAGGAAAACAGCATGTAGCTCTGATTAAAGGAGAT
GTAAATAAAGAACCTGTACTTGTAAGGATACATTCTGAATGTCTTACAGGGGATATATTAGGGTCGCTAAGATGTGACTG
TGGTGACCAGCTTCATGCGGCAATGGAAAGAATAGGACAGGAAGGAGGAATACTAGTTTATCTGAGGCAGGAAGGAAGGG
GCATAGGACTTTTAAACAAGATTAAAGCGTATCATCTGCAAGATCAAGGGCTTGATACTGTTGAAGCGAATATTAAGCTT
GGTTTTCCACCCGATTTAAGAGAGTACAATATAGCTGCACAGATTTTGAAAGATATAGGAGTTAAAAAGATAAGGATTAT
GACAAATAATCCGCAAAAAATTACGGAATTATCAGACTATGGCCTTGATGTTGTAGAAAGGGTTTCTATAGAAATTTGTC
CAAATCATTATAATGAAAAATACCTCAAGACAAAAAAGGAAAAAATGGGACATCTAATTTTGGAAGTGTAA

Upstream 100 bases:

>100_bases
GTAGAAAAACTAATAGGGAAAAAGGATATAAAAGATTTATTAAAAGAAAATGGATTTATATAGATGTTGATGACTTTTCT
AAGTTAAGGAGGAAAGACCA

Downstream 100 bases:

>100_bases
AATGCTACAAAAAAATGAATTAAATGTAATTATTAAGTATATAATGAAAGAATATTAATAAGGAGAGTGTATAGTTTATG
AAAATATATGAAGGAAAACT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MFDRIEDAIEDIKQGKMIIVVDDENRENEGDLVMAAEKVTGEHINFMIKYGRGLVCVPMTEKRLNELGIYQMVENNTDHK
ETAFTVSVDYKECTTGISAFERALTVKKLVDDNSKPEDFTKPGHIFPLRAKDGGVLVRAGHTEAAVDLAVLAGLKPAGVI
CEIIKDDGNMARLPDLLEFAKKFGLRIISIEDLIKYRMKNEILVRRVAQAKLPTKYGNFEIVGYEEILTGKQHVALIKGD
VNKEPVLVRIHSECLTGDILGSLRCDCGDQLHAAMERIGQEGGILVYLRQEGRGIGLLNKIKAYHLQDQGLDTVEANIKL
GFPPDLREYNIAAQILKDIGVKKIRIMTNNPQKITELSDYGLDVVERVSIEICPNHYNEKYLKTKKEKMGHLILEV

Sequences:

>Translated_396_residues
MFDRIEDAIEDIKQGKMIIVVDDENRENEGDLVMAAEKVTGEHINFMIKYGRGLVCVPMTEKRLNELGIYQMVENNTDHK
ETAFTVSVDYKECTTGISAFERALTVKKLVDDNSKPEDFTKPGHIFPLRAKDGGVLVRAGHTEAAVDLAVLAGLKPAGVI
CEIIKDDGNMARLPDLLEFAKKFGLRIISIEDLIKYRMKNEILVRRVAQAKLPTKYGNFEIVGYEEILTGKQHVALIKGD
VNKEPVLVRIHSECLTGDILGSLRCDCGDQLHAAMERIGQEGGILVYLRQEGRGIGLLNKIKAYHLQDQGLDTVEANIKL
GFPPDLREYNIAAQILKDIGVKKIRIMTNNPQKITELSDYGLDVVERVSIEICPNHYNEKYLKTKKEKMGHLILEV
>Mature_396_residues
MFDRIEDAIEDIKQGKMIIVVDDENRENEGDLVMAAEKVTGEHINFMIKYGRGLVCVPMTEKRLNELGIYQMVENNTDHK
ETAFTVSVDYKECTTGISAFERALTVKKLVDDNSKPEDFTKPGHIFPLRAKDGGVLVRAGHTEAAVDLAVLAGLKPAGVI
CEIIKDDGNMARLPDLLEFAKKFGLRIISIEDLIKYRMKNEILVRRVAQAKLPTKYGNFEIVGYEEILTGKQHVALIKGD
VNKEPVLVRIHSECLTGDILGSLRCDCGDQLHAAMERIGQEGGILVYLRQEGRGIGLLNKIKAYHLQDQGLDTVEANIKL
GFPPDLREYNIAAQILKDIGVKKIRIMTNNPQKITELSDYGLDVVERVSIEICPNHYNEKYLKTKKEKMGHLILEV

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=58.3333333333333, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=49.2537313432836, Blast_Score=222, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=48.5576923076923, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319438, Length=175, Percent_Identity=45.7142857142857, Blast_Score=139, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44428; Mature: 44428

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRIEDAIEDIKQGKMIIVVDDENRENEGDLVMAAEKVTGEHINFMIKYGRGLVCVPMT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHHCCCCEEEEEEECCCEEEECCC
EKRLNELGIYQMVENNTDHKETAFTVSVDYKECTTGISAFERALTVKKLVDDNSKPEDFT
HHHHHHCCHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPGHIFPLRAKDGGVLVRAGHTEAAVDLAVLAGLKPAGVICEIIKDDGNMARLPDLLEFA
CCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHHH
KKFGLRIISIEDLIKYRMKNEILVRRVAQAKLPTKYGNFEIVGYEEILTGKQHVALIKGD
HHHCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCEEEEEECC
VNKEPVLVRIHSECLTGDILGSLRCDCGDQLHAAMERIGQEGGILVYLRQEGRGIGLLNK
CCCCCEEEEEECHHHCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
IKAYHLQDQGLDTVEANIKLGFPPDLREYNIAAQILKDIGVKKIRIMTNNPQKITELSDY
HHHEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHC
GLDVVERVSIEICPNHYNEKYLKTKKEKMGHLILEV
CCCHHHHEEEEECCCCCCHHHHHHHHHHHCCEEEEC
>Mature Secondary Structure
MFDRIEDAIEDIKQGKMIIVVDDENRENEGDLVMAAEKVTGEHINFMIKYGRGLVCVPMT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHHCCCCEEEEEEECCCEEEECCC
EKRLNELGIYQMVENNTDHKETAFTVSVDYKECTTGISAFERALTVKKLVDDNSKPEDFT
HHHHHHCCHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPGHIFPLRAKDGGVLVRAGHTEAAVDLAVLAGLKPAGVICEIIKDDGNMARLPDLLEFA
CCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHHH
KKFGLRIISIEDLIKYRMKNEILVRRVAQAKLPTKYGNFEIVGYEEILTGKQHVALIKGD
HHHCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCEEEEEECC
VNKEPVLVRIHSECLTGDILGSLRCDCGDQLHAAMERIGQEGGILVYLRQEGRGIGLLNK
CCCCCEEEEEECHHHCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
IKAYHLQDQGLDTVEANIKLGFPPDLREYNIAAQILKDIGVKKIRIMTNNPQKITELSDY
HHHEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHC
GLDVVERVSIEICPNHYNEKYLKTKKEKMGHLILEV
CCCHHHHEEEEECCCCCCHHHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA