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The map label for this gene is rmlC

Identifier: 16519754

GI number: 16519754

Start: 449037

End: 449624

Strand: Direct

Name: rmlC

Synonym: NGR_a03520

Alternate gene names: 16519754

Gene position: 449037-449624 (Clockwise)

Preceding gene: 16519755

Following gene: 16519752

Centisome position: 83.75

GC content: 53.4

Gene sequence:

>588_bases
GTGGGCGGAACTGAGTTGGACGAAATGTATTTTCAAAGCCTGTCGATAGCCGAAGTCAAGTTAATTAGGCCTAGGAAGTT
TGGCGATTGCCGCGGCTATTTCAGCGAAGTATTCAGGGAAAAATGGTTCCGCAAAAATGTTGCCGATGTCGGACTTGTTC
AGGATAATGAATCACTCTCCGCTCAGATCGGGACGGTAAGGGGCCTTCACTTTCAGCTCGAGCCTTTCGCGCAAGGAAAG
CTTGTCCGCTGTACACGCGGCGCGCTGTTCGACGTCGCGGTGGACGTCAGGGTCGGGTCACCAACATACGGGAAATGGGT
TTCCGCCGAGCTATCTCAGGAAAATGGCGCGCAGCTTTGGGTTCCTGCGGGCTTCGCGCATGGTTTCATGACGCTTAAGG
CGGACACGGTAATCAGCTACAAGGTGACAGCGCCCTATAGCGCTGAACATGATCGCGGACTGAAATGGGACGATCCCGCC
ATCGGAATCAATTGGCCAAAGATGACCACGTACGTTCTGTCGGAAAAGGACTCCAGTCAGCCATCACTCTGCGAACTTCC
GGTCTCGTTTCAATACGTGAAGGTGTAG

Upstream 100 bases:

>100_bases
TGCCGAGCGCCTAAGTGAGTCTCTGGATCGGAGCCCACAATCGCGCTATGAGTTGAGGTTCGGTTTTTATCCTCAACTCC
TTGCCAGAGCACGAGAATTA

Downstream 100 bases:

>100_bases
CTCTCGCCAACTTCAAAACGACCTTCGACGCACTCTCGAAGACCATCGGCAACGTTTGCAATCCCATCAACAGAACGCTG
GAACTGCCTCAATCCTCAAG

Product: dTDP-rhamnose 3,5-epimerase RmlC

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MGGTELDEMYFQSLSIAEVKLIRPRKFGDCRGYFSEVFREKWFRKNVADVGLVQDNESLSAQIGTVRGLHFQLEPFAQGK
LVRCTRGALFDVAVDVRVGSPTYGKWVSAELSQENGAQLWVPAGFAHGFMTLKADTVISYKVTAPYSAEHDRGLKWDDPA
IGINWPKMTTYVLSEKDSSQPSLCELPVSFQYVKV

Sequences:

>Translated_195_residues
MGGTELDEMYFQSLSIAEVKLIRPRKFGDCRGYFSEVFREKWFRKNVADVGLVQDNESLSAQIGTVRGLHFQLEPFAQGK
LVRCTRGALFDVAVDVRVGSPTYGKWVSAELSQENGAQLWVPAGFAHGFMTLKADTVISYKVTAPYSAEHDRGLKWDDPA
IGINWPKMTTYVLSEKDSSQPSLCELPVSFQYVKV
>Mature_194_residues
GGTELDEMYFQSLSIAEVKLIRPRKFGDCRGYFSEVFREKWFRKNVADVGLVQDNESLSAQIGTVRGLHFQLEPFAQGKL
VRCTRGALFDVAVDVRVGSPTYGKWVSAELSQENGAQLWVPAGFAHGFMTLKADTVISYKVTAPYSAEHDRGLKWDDPAI
GINWPKMTTYVLSEKDSSQPSLCELPVSFQYVKV

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family

Homologues:

Organism=Escherichia coli, GI1788350, Length=172, Percent_Identity=47.6744186046512, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550412, Length=176, Percent_Identity=39.7727272727273, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RMLC_RHISN (P55468)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443874.1
- ProteinModelPortal:   P55468
- SMR:   P55468
- GeneID:   962164
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a03520
- HOGENOM:   HBG730537
- ProtClustDB:   CLSK881676
- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- PANTHER:   PTHR21047
- ProDom:   PD001462
- TIGRFAMs:   TIGR01221

Pfam domain/function: PF00908 dTDP_sugar_isom; SSF51182 RmlC_like_cupin

EC number: =5.1.3.13

Molecular weight: Translated: 21852; Mature: 21721

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: BINDING 31-31 BINDING 36-36 BINDING 54-54 BINDING 56-56 BINDING 67-67 BINDING 70-70 BINDING 80-80 BINDING 91-91 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGTELDEMYFQSLSIAEVKLIRPRKFGDCRGYFSEVFREKWFRKNVADVGLVQDNESLS
CCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCE
AQIGTVRGLHFQLEPFAQGKLVRCTRGALFDVAVDVRVGSPTYGKWVSAELSQENGAQLW
EEECEEEEEEEEECCCCCCCEEEECCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCEEE
VPAGFAHGFMTLKADTVISYKVTAPYSAEHDRGLKWDDPAIGINWPKMTTYVLSEKDSSQ
EECCCCCCEEEEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
PSLCELPVSFQYVKV
CCEEECCCCEEEEEC
>Mature Secondary Structure 
GGTELDEMYFQSLSIAEVKLIRPRKFGDCRGYFSEVFREKWFRKNVADVGLVQDNESLS
CCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCE
AQIGTVRGLHFQLEPFAQGKLVRCTRGALFDVAVDVRVGSPTYGKWVSAELSQENGAQLW
EEECEEEEEEEEECCCCCCCEEEECCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCEEE
VPAGFAHGFMTLKADTVISYKVTAPYSAEHDRGLKWDDPAIGINWPKMTTYVLSEKDSSQ
EECCCCCCEEEEEECEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
PSLCELPVSFQYVKV
CCEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424