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Identifier: 16519736

GI number: 16519736

Start: 474885

End: 475712

Strand: Direct

Name: Not Available

Synonym: NGR_a03700

Alternate gene names: 16519736

Gene position: 474885-475712 (Clockwise)

Preceding gene: 16519737

Following gene: 16519735

Centisome position: 88.57

GC content: 60.63

Gene sequence:

>828_bases
TTGACAAGCGACCTCGACACTCGGCTCGATTTGCTTCGGAACATCACCAGCAAGGTTGGAGCCTTCGCGCTGGCCCGGTT
TGGCAATCTTTCCCACATCGTCATCGAGACCAAGGGTGAGGCCGACTACGTCAGCGCAGCCGATCGTGACGCCGAAAGTC
TTGCCCGCAGGCTGATCCACGCCCAGTTCCCCGCCGACGCGATCGTCGGCGAGGAACAGCTTGGCGATGCCGAAGTTGAC
CATTGGTTGATCGATCCGATCGATGGGACCGCGAATTTCCTGTCGGGCATACCGCTCTGGGCGGTCTCTATCGCTTTTGT
CCGCAACAAGGAGCCGGTCCTCGGCGCTGTTGCGCTACCGGCACTCGATACTCTGTTGTGGGCTTCTGTGGATGGCCCAT
TGCATGGGACAGGCTCGGTTTCGCCGCTTGTCGGGGCGCAGCCGATCGCCTTTGGCATAGGCCGCAACCGAACATGGCCC
CTCGCCCATCGCCTCGAAGTCGAGGCCGCGTTTGAGGCGCGCGGTTATCATATCGTCTGCCTTGGAAGCTGTGCCGCAGC
ACTTGCGATGGTCGCGGCGGGTCGGCTTGCCGGCTATGTCGAGCACGGCACCCATCTTTGGGATTGTGCGGCCGGACATG
TCTTGTGTCGCGCAGCCGGTGCGCCTTCGTCCATTCTCTTCGAGGCAGATGGGAAAGTCGCCATCATTGCCGCTCCGCAG
CATCTCAGAGTAACGGCCAAAGCCGACGCGCGATCCCTATCCGAAAAACACATCTTCGATCCGGGTTCAGATCGAATATC
GCACAGGATGGAGAGCAGTGCAGATTGA

Upstream 100 bases:

>100_bases
ACCGCTACGTGCTGTCGGAGTCGTCCTACTATCAGCGGGCACACGCTATCGCTCTGCGGCTTGAAGAGATGGTTGCGTCG
GCGCGGGATCGGGCGGCAAA

Downstream 100 bases:

>100_bases
CGCGCGTCATGGCTCTGCTGATAAAACGAGCCACCAAGTGATGCCCTTGCCGTTCGGCAAGCTGGTCCTGTGCCTGCTCG
TCGCTGGGACGATTGCTGCT

Product: inositol-1-monophosphatase; 29.1 kDa integral membrane protein

Products: myo-Inositol; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MTSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIHAQFPADAIVGEEQLGDAEVD
HWLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALPALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWP
LAHRLEVEAAFEARGYHIVCLGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQ
HLRVTAKADARSLSEKHIFDPGSDRISHRMESSAD

Sequences:

>Translated_275_residues
MTSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIHAQFPADAIVGEEQLGDAEVD
HWLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALPALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWP
LAHRLEVEAAFEARGYHIVCLGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQ
HLRVTAKADARSLSEKHIFDPGSDRISHRMESSAD
>Mature_274_residues
TSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIHAQFPADAIVGEEQLGDAEVDH
WLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALPALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWPL
AHRLEVEAAFEARGYHIVCLGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQH
LRVTAKADARSLSEKHIFDPGSDRISHRMESSAD

Specific function: Unknown

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

Organism=Homo sapiens, GI5031789, Length=235, Percent_Identity=26.3829787234043, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI221625487, Length=235, Percent_Identity=26.3829787234043, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=227, Percent_Identity=26.8722466960352, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202570, Length=232, Percent_Identity=26.2931034482759, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321836, Length=244, Percent_Identity=27.8688524590164, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357303, Length=232, Percent_Identity=26.7241379310345, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357329, Length=232, Percent_Identity=29.3103448275862, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664918, Length=243, Percent_Identity=29.6296296296296, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357957, Length=241, Percent_Identity=26.5560165975104, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664922, Length=211, Percent_Identity=31.7535545023697, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664926, Length=245, Percent_Identity=26.9387755102041, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4FL_RHISN (P55450)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443856.1
- ProteinModelPortal:   P55450
- SMR:   P55450
- GeneID:   962177
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a03700
- HOGENOM:   HBG730251
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550
- PANTHER:   PTHR20854
- PRINTS:   PR00377

Pfam domain/function: PF00459 Inositol_P

EC number: 3.1.3.25 [C]

Molecular weight: Translated: 29147; Mature: 29016

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 71-71 BINDING 208-208

Signals:

None

Transmembrane regions:

HASH(0xc723c54)-; HASH(0xb01c378)-; HASH(0xc30a5d4)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIH
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHH
AQFPADAIVGEEQLGDAEVDHWLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALP
HCCCCHHHCCHHHCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHH
ALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWPLAHRLEVEAAFEARGYHIVC
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHEEEEEEECCCCEEEEE
LGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQ
HHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHEEECCCCCCEEEEECCCCEEEEECCC
HLRVTAKADARSLSEKHIFDPGSDRISHRMESSAD
EEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCH
>Mature Secondary Structure 
TSDLDTRLDLLRNITSKVGAFALARFGNLSHIVIETKGEADYVSAADRDAESLARRLIH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHH
AQFPADAIVGEEQLGDAEVDHWLIDPIDGTANFLSGIPLWAVSIAFVRNKEPVLGAVALP
HCCCCHHHCCHHHCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHH
ALDTLLWASVDGPLHGTGSVSPLVGAQPIAFGIGRNRTWPLAHRLEVEAAFEARGYHIVC
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHEEEEEEECCCCEEEEE
LGSCAAALAMVAAGRLAGYVEHGTHLWDCAAGHVLCRAAGAPSSILFEADGKVAIIAAPQ
HHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHEEECCCCCCEEEEECCCCEEEEECCC
HLRVTAKADARSLSEKHIFDPGSDRISHRMESSAD
EEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; 1D-myo-Inositol 1-phosphate [C]

Specific reaction: H2O + 1D-myo-Inositol 1-phosphate --> myo-Inositol + Phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424