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The map label for this gene is msrA

Identifier: 163845180

GI number: 163845180

Start: 1042103

End: 1042759

Strand: Reverse

Name: msrA

Synonym: BSUIS_B1064

Alternate gene names: 163845180

Gene position: 1042759-1042103 (Counterclockwise)

Preceding gene: 163845181

Following gene: 163845177

Centisome position: 74.44

GC content: 56.77

Gene sequence:

>657_bases
ATGAGTTTCTTCGACAGCTACCGCAAGAAGATGCAGATGCCTTCAAAAGAAGAAGTATTGCCAGGGCGTGTTCAACCGAT
CCCGACGGCTGCGGCGCATTTCGTTTCCGGCCATCCGCTAAAGGGGCCATGGCCTGACGGGATGAAGCAGGTTCTGTTTG
GCATGGGCTGCTTCTGGGGTGCGGAGCGGCTTTTCTGGCAGGTGCCGGGCGTGTATGTGACGGCTGTAGGCTATGCAGGC
GGCATCACACCCAATCCGACCTATGAGGAAACCTGCACGGGGCTGACCGGCCATGCGGAAGTGGTGCTGGTGGTCTATGA
CCCGAAGGTTGTGACGCTCAATGAATTGCTGGCCCTTTTCTGGGAAGAACATGATCCGACCCAGGGGATGCGGCAGGGCA
ATGATATCGGCACGACCTATCGCTCGGTGATCTATACGTTTAATGCGGTCGATCGTGCGGTTGCGGAAAAGAGCCGCGAT
GCTTATTCGCAGGCACTCGCCTCACGCGGCCTTGGTCCTGTCACGACGCAAATCGCCGATGCGCCCGATTTCTATTATGC
TGAGGATTATCATCAGCAATATCTGGCGAAAAATCCGGATGGCTATTGCGGGTTGCGCGGAACCGGTGTGAGTTGCCCGA
TCCCTCTTGCGCATTGA

Upstream 100 bases:

>100_bases
TTCGGTGTGCTTGCGCTTCTGTTCTATGCCATCGGTCATCGCCGGGAGCGGCCTCTTGGCCGCTTCACTGCCCGGTAATT
AAATTCAGGAGGAAGGGGCC

Downstream 100 bases:

>100_bases
TCAGGCGCGCGCTTACCAGTGCGGCGGCTTGGTGACGGGCACGTCCGGCGCAGCCTGTTCTTTCAGTTCCAGAAAGCGGT
TGGTAAGGGCGTTCAGCTTC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAG
GITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRD
AYSQALASRGLGPVTTQIADAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH

Sequences:

>Translated_218_residues
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAG
GITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRD
AYSQALASRGLGPVTTQIADAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
>Mature_217_residues
SFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAGG
ITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDA
YSQALASRGLGPVTTQIADAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=200, Percent_Identity=59, Blast_Score=257, Evalue=5e-69,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=59.2391304347826, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI208609993, Length=200, Percent_Identity=45, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1790665, Length=200, Percent_Identity=56, Blast_Score=224, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=36.0544217687075, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.144578313253, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=40.8450704225352, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=40.1408450704225, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=40, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_BRUA1 (B2SC53)

Other databases:

- EMBL:   CP000888
- RefSeq:   YP_001932886.1
- ProteinModelPortal:   B2SC53
- SMR:   B2SC53
- GeneID:   6325900
- GenomeReviews:   CP000888_GR
- KEGG:   bmc:BAbS19_II09570
- HOGENOM:   HBG748152
- OMA:   QETSFEQ
- ProtClustDB:   PRK00058
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 24017; Mature: 23886

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: ACT_SITE 57-57

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWG
CCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLFWQVPGVYVTAVGYAGGITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALF
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEHHHHHHHH
WEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDAYSQALASRGLGPVTTQIAD
HHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
APDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWG
CHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLFWQVPGVYVTAVGYAGGITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALF
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEHHHHHHHH
WEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDAYSQALASRGLGPVTTQIAD
HHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
APDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA