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The map label for this gene is ahpC [H]

Identifier: 163844838

GI number: 163844838

Start: 674728

End: 675282

Strand: Reverse

Name: ahpC [H]

Synonym: BSUIS_B0694

Alternate gene names: 163844838

Gene position: 675282-674728 (Counterclockwise)

Preceding gene: 163844841

Following gene: 163844837

Centisome position: 48.21

GC content: 56.22

Gene sequence:

>555_bases
ATGCTCGGCATCGGCGACAAGCTTCCCTCTTTCAAGGTCACCGGCGTAAAGCCCGGTTTCAACCATCATCAAGAAAACGG
CGTTTCGGCATTCGAGGAAGTGACGGAACAGAGCTTCCCCGGCAAGTGGAAAGTCATTTTCTTCTACCCGAAGGACTTCA
CCTTCGTCTGCCCGACGGAAATCGCTGAATTTGCGCGTCTGGCTTCGGAATTTGAAGATCGCGATGCAGTTGTGCTTGGC
GGTTCGACCGATAATGAATTCGTCAAGCTGGCATGGCGCCGCGACCACAAGGATCTCAACAAGCTGCCGATCTGGTCGTT
TGCTGATACCAATGGTTCGCTGGTCGATGGCCTCGGCGTTCGTTCGCCCGATGGTGTTGCCTATCGCTACACCTTCGTTG
TGGACCCGGACAATGTGATCCAGCACGTCTATGCAACCAATCTCAATGTCGGCCGTGCACCGAAGGACACGCTGCGTGTT
CTCGACGCCCTCCAGACCGACGAGCTTTGCCCGTGCAACCGCGAAGTCGGTGGTGAGACGCTCAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
CTTTGACCGATGGTTGCAAGCGGCCTATAAAGGAGTCGCGAAGGAAAATTCTGAAATTTCTGAATTTTCTGTATAACCAT
AGAATTACAGGCAGGTAAAA

Downstream 100 bases:

>100_bases
TCGGCTATGACAATGGCGTGTGAGGCGGGTTCAGGCCCGCCTTTCTTTTATCCTGTTTCAAAGACATAATGAGGGTTCCA
TGTCGATTGACGACCTGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MLGIGDKLPSFKVTGVKPGFNHHQENGVSAFEEVTEQSFPGKWKVIFFYPKDFTFVCPTEIAEFARLASEFEDRDAVVLG
GSTDNEFVKLAWRRDHKDLNKLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFVVDPDNVIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKAA

Sequences:

>Translated_184_residues
MLGIGDKLPSFKVTGVKPGFNHHQENGVSAFEEVTEQSFPGKWKVIFFYPKDFTFVCPTEIAEFARLASEFEDRDAVVLG
GSTDNEFVKLAWRRDHKDLNKLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFVVDPDNVIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKAA
>Mature_184_residues
MLGIGDKLPSFKVTGVKPGFNHHQENGVSAFEEVTEQSFPGKWKVIFFYPKDFTFVCPTEIAEFARLASEFEDRDAVVLG
GSTDNEFVKLAWRRDHKDLNKLPIWSFADTNGSLVDGLGVRSPDGVAYRYTFVVDPDNVIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKAA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=39.0374331550802, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=34.7593582887701, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=34.7593582887701, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=34.7593582887701, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI32483377, Length=185, Percent_Identity=36.2162162162162, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI5802974, Length=188, Percent_Identity=35.6382978723404, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=35.8490566037736, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI33188454, Length=89, Percent_Identity=46.0674157303371, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786822, Length=174, Percent_Identity=37.3563218390805, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=38.5026737967914, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=38.5026737967914, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=189, Percent_Identity=37.5661375661376, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI25153706, Length=138, Percent_Identity=29.7101449275362, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323613, Length=187, Percent_Identity=39.572192513369, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320661, Length=187, Percent_Identity=36.8983957219251, Blast_Score=110, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6319407, Length=169, Percent_Identity=31.3609467455621, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17157991, Length=166, Percent_Identity=37.9518072289157, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641739, Length=166, Percent_Identity=37.9518072289157, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357347, Length=191, Percent_Identity=32.4607329842932, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=35.2941176470588, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656348, Length=157, Percent_Identity=34.3949044585987, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864676, Length=157, Percent_Identity=34.3949044585987, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20469; Mature: 20469

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGDKLPSFKVTGVKPGFNHHQENGVSAFEEVTEQSFPGKWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECHHH
IAEFARLASEFEDRDAVVLGGSTDNEFVKLAWRRDHKDLNKLPIWSFADTNGSLVDGLGV
HHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEECCCCC
RSPDGVAYRYTFVVDPDNVIQHVYATNLNVGRAPKDTLRVLDALQTDELCPCNREVGGET
CCCCCEEEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCE
LKAA
ECCC
>Mature Secondary Structure
MLGIGDKLPSFKVTGVKPGFNHHQENGVSAFEEVTEQSFPGKWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECHHH
IAEFARLASEFEDRDAVVLGGSTDNEFVKLAWRRDHKDLNKLPIWSFADTNGSLVDGLGV
HHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCEECCCCC
RSPDGVAYRYTFVVDPDNVIQHVYATNLNVGRAPKDTLRVLDALQTDELCPCNREVGGET
CCCCCEEEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCE
LKAA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]