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The map label for this gene is fcl [C]

Identifier: 163844588

GI number: 163844588

Start: 404026

End: 405006

Strand: Reverse

Name: fcl [C]

Synonym: BSUIS_B0421

Alternate gene names: 163844588

Gene position: 405006-404026 (Counterclockwise)

Preceding gene: 163844589

Following gene: 163844581

Centisome position: 28.91

GC content: 59.02

Gene sequence:

>981_bases
ATGATTTCTACGGCTGAGACCGGGCGCGAACCCGTCTATTCACTCACGGGAAAGAAAATCTTCGTCGCCGGTCACACCGG
CATGGTCGGCTCAGCCATTTTGCGGCGCCTCCAGCATGAGGATTGCGACATCATCACCGCCGCGCACAGCGTGCTGGACC
TGACCCGACAAGGCCCAACGGAAAATTTCATCAGCGGCCACAGGCCCGATGTCATTATCATCGCTGCCGCGCGCGTTGGC
GGCATTCTCGCAAATTCGCGATTTCCAGCGGATTTTCTCTATGACAATCTGGCCATCGGCATGAACCTCATTCATGCCGC
ACATCAGATCGGTGTGGAACGCCTGCTCTGGCTGGGATCAAGCTGCATCTATCCGCGCGACGCCGCCCAGCCACTCACCG
AGGATGCCCTGTTGACCGGCCCGCTGGAGCCGACCAACGAGGCCTATGCCATCGCCAAGATTGCCGGATTGAAATATGCG
CAAAGCTGCGCGCGCCAGTTTGGCGACCGTTTCATCACGGCCATGCCGACCAATCTTTATGGACCGAACGACAATTTCGA
TCCCACCAGCTCGCATGTCCTGCCGGCGCTGATAAGGCGGGTGCATGAAGCCAGGATGAGAGGTGCGGAAGAAGTGGTGC
TTTGGGGCAGCGGCAAGCCCTTGCGGGAATTCCTGCATGTGGACGACCTCGCCGATGCGTGCCTGCATCTCCTGCGCTTT
TATAATGGCATCGAGCCGGTGAATATCGGCAGCGGAGAAGAAATCTCGATCAAGGAACTGGCACTCACCGTTGCACGTAT
CGTTGGCTATGAAGGCCGCTTCGAGCACGACCTGAGTAAACCGGACGGCACGCCGCGCAAGCTGCTCGATACATCGCGCA
TAGAGGCGCTTGGCTGGCAGCCGCGCATCCGTCTCGAAGACGGCTTGCGCGATGTCTATCGAAACTGGCTGGAAGAAACC
GCAGGCTCCGTCGCCGCTTAA

Upstream 100 bases:

>100_bases
AAAGACCGTCTGGGCTGGCAACATACGACCGGCTTTGAAAATCTCGTGGCTGAAATGGTGGATTGGGATCTGCGCAACAT
CATGCGGGAGGTAGGACGCA

Downstream 100 bases:

>100_bases
AAACAAATAGTTATAGCTGTTTCCAAGACGCCACTTTAACCGGAACCACTCTAAAAAGCGCCGATCTGTTTGTGTCAGAT
CGGCGCTATTATTGTATCAC

Product: hypothetical protein

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MISTAETGREPVYSLTGKKIFVAGHTGMVGSAILRRLQHEDCDIITAAHSVLDLTRQGPTENFISGHRPDVIIIAAARVG
GILANSRFPADFLYDNLAIGMNLIHAAHQIGVERLLWLGSSCIYPRDAAQPLTEDALLTGPLEPTNEAYAIAKIAGLKYA
QSCARQFGDRFITAMPTNLYGPNDNFDPTSSHVLPALIRRVHEARMRGAEEVVLWGSGKPLREFLHVDDLADACLHLLRF
YNGIEPVNIGSGEEISIKELALTVARIVGYEGRFEHDLSKPDGTPRKLLDTSRIEALGWQPRIRLEDGLRDVYRNWLEET
AGSVAA

Sequences:

>Translated_326_residues
MISTAETGREPVYSLTGKKIFVAGHTGMVGSAILRRLQHEDCDIITAAHSVLDLTRQGPTENFISGHRPDVIIIAAARVG
GILANSRFPADFLYDNLAIGMNLIHAAHQIGVERLLWLGSSCIYPRDAAQPLTEDALLTGPLEPTNEAYAIAKIAGLKYA
QSCARQFGDRFITAMPTNLYGPNDNFDPTSSHVLPALIRRVHEARMRGAEEVVLWGSGKPLREFLHVDDLADACLHLLRF
YNGIEPVNIGSGEEISIKELALTVARIVGYEGRFEHDLSKPDGTPRKLLDTSRIEALGWQPRIRLEDGLRDVYRNWLEET
AGSVAA
>Mature_326_residues
MISTAETGREPVYSLTGKKIFVAGHTGMVGSAILRRLQHEDCDIITAAHSVLDLTRQGPTENFISGHRPDVIIIAAARVG
GILANSRFPADFLYDNLAIGMNLIHAAHQIGVERLLWLGSSCIYPRDAAQPLTEDALLTGPLEPTNEAYAIAKIAGLKYA
QSCARQFGDRFITAMPTNLYGPNDNFDPTSSHVLPALIRRVHEARMRGAEEVVLWGSGKPLREFLHVDDLADACLHLLRF
YNGIEPVNIGSGEEISIKELALTVARIVGYEGRFEHDLSKPDGTPRKLLDTSRIEALGWQPRIRLEDGLRDVYRNWLEET
AGSVAA

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=284, Percent_Identity=32.7464788732394, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI7657641, Length=337, Percent_Identity=23.1454005934718, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI42516563, Length=332, Percent_Identity=25.6024096385542, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788365, Length=314, Percent_Identity=51.5923566878981, Blast_Score=335, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17554428, Length=286, Percent_Identity=30.4195804195804, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI115532424, Length=336, Percent_Identity=22.9166666666667, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19922778, Length=291, Percent_Identity=31.6151202749141, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21356223, Length=326, Percent_Identity=24.8466257668712, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35842; Mature: 35842

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTAETGREPVYSLTGKKIFVAGHTGMVGSAILRRLQHEDCDIITAAHSVLDLTRQGPT
CCCCCCCCCCCCEECCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
ENFISGHRPDVIIIAAARVGGILANSRFPADFLYDNLAIGMNLIHAAHQIGVERLLWLGS
HHHCCCCCCCEEEEECHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SCIYPRDAAQPLTEDALLTGPLEPTNEAYAIAKIAGLKYAQSCARQFGDRFITAMPTNLY
CCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
GPNDNFDPTSSHVLPALIRRVHEARMRGAEEVVLWGSGKPLREFLHVDDLADACLHLLRF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YNGIEPVNIGSGEEISIKELALTVARIVGYEGRFEHDLSKPDGTPRKLLDTSRIEALGWQ
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PRIRLEDGLRDVYRNWLEETAGSVAA
CCEEHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MISTAETGREPVYSLTGKKIFVAGHTGMVGSAILRRLQHEDCDIITAAHSVLDLTRQGPT
CCCCCCCCCCCCEECCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
ENFISGHRPDVIIIAAARVGGILANSRFPADFLYDNLAIGMNLIHAAHQIGVERLLWLGS
HHHCCCCCCCEEEEECHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SCIYPRDAAQPLTEDALLTGPLEPTNEAYAIAKIAGLKYAQSCARQFGDRFITAMPTNLY
CCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
GPNDNFDPTSSHVLPALIRRVHEARMRGAEEVVLWGSGKPLREFLHVDDLADACLHLLRF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YNGIEPVNIGSGEEISIKELALTVARIVGYEGRFEHDLSKPDGTPRKLLDTSRIEALGWQ
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PRIRLEDGLRDVYRNWLEETAGSVAA
CCEEHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]