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The map label for this gene is cycA [H]

Identifier: 163844254

GI number: 163844254

Start: 53160

End: 54563

Strand: Reverse

Name: cycA [H]

Synonym: BSUIS_B0060

Alternate gene names: 163844254

Gene position: 54563-53160 (Counterclockwise)

Preceding gene: 163844255

Following gene: 163844251

Centisome position: 3.9

GC content: 52.92

Gene sequence:

>1404_bases
ATGAATACTATATCAAAGCCTTCCGTTGATTTGCACCGGGAGGAGGAACCTCATCTTGCACGTAATCTATCCAATCGACA
CCTCCAGCTGATCGCCATCGGCGGCACGATCGGCACCGGCCTTTTCATGGGGTCGGGCAAAGCCGTTTCGCTGGCGGGGC
CTTCGATCCTGCTCATCTATGCGATCACCGGCTTCATGCTGTTTTTCGTCATGCGCGCGCTGGGCGAAATTCTGCTTTCC
AACCTGCAATATCGCTCCTTCGCGGACTTCGCGGGTGACTATCTGGGGCCATGCGCACAATTTTTCACCGGCTGGACCTA
CTGGCTATGCTGGATCGTGACGGCCGTGGCCGAAGTCGTGGCCGTTTCCGGCTATGTCTCATTCTGGTTTCCTCATCTGG
CGCCGTGGATCCCGGCCCTCGGCCTCATCACAATACTGCTGATACTGAATCTGCCGACCGTGCGCAATTTTGGTGAAATC
GAATTCTGGTTCGCTCTCATCAAAATTATCACCATTATCGGGCTGATTATTACTGGCATATACATGCTCATGACGGGCTT
TGTCTTGCCCAATGACACCCAGGCATCAATTGCCCATCTGTGGAACCATGGCGGGTTCTTCCCCAATGGTTCTCTTGGCT
TTATCGCCGGGTTCCAGATATCGGTTTTTGCTTTCGTCGGTATCGAACTCGTGGGCACGGCTGCTGCGGAGGCCGAAAAC
CCGATGCGAAACCTGCCGAAGGCGATCAATAATATCCCGATCCGTATCGTTCTTTTTTATATTGGCGCGCTGTTTGTCAT
CATCACCGTCACTCCGTGGAATCAGGTGGACCCGAATTCAAGCCCCTTCGTGGCCATGTTCTCGCTCGCCGGTATCGGCA
TAGCAGCCCATTTCATAAATTTTGTCGTTCTGACTTCGGCATCGTCGAGTTCAAATTCCGGCATCTACTCGACCTCGCGC
ATGGTCTACGGCCTTGCCACTGTCGGGCTTGCACCGAAAGCCTTCAGTAAACTGAGCAATCGCAAGGTGCCGGTCCACGC
GCTAATCTTCTCTTGCATATTCCTGCTGTCGAGCGTGGTTCTGCTTTATGCAGGCCAGAGCATGATCCAGGTCTTCACAC
TCGTCACGACGATTTCGGCGCTCCTGTTCATTTTCATCTGGTCGATTATCCTGGTGTCTTACCTGCAATATCGCCGCAAG
CACCCCGAACGGCATGAAAAATCCACCTTCAAGATGCCCGGTAGACGTGCATCTGTCGTTATGGTCTTCATTTTCTTTGC
CTTCGTCCTTTGGGCGCTGACACAGGAACCGGATACGTTAGCCGCGATGAAAGTCACGCCATTGTGGTTCGTGCTTCTGG
GCATTGCCTATTGGGTCATGAAATTAAAGCAAAAGCAGAGCTAA

Upstream 100 bases:

>100_bases
AGAAAGCGTCGTGTGCCTGAAACGACATATAGGAGAGGGTGCAGCTACGCGCATTCGCGCGCAGTGTGATTATGCGTTTA
CCAACATAAGAGGCGCTTGC

Downstream 100 bases:

>100_bases
AAAATATGAAGCCCGCCATTTGGCGGGCTTTCCATGCACATCTCTCAACGAGGCAAAACGGAACTGCCCATCAAATCCGC
ATCAATAGCATGGGCTGCCT

Product: hypothetical protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVSGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNDTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGRRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS

Sequences:

>Translated_467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVSGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNDTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGRRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
>Mature_467_residues
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIYAITGFMLFFVMRALGEILLS
NLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVVAVSGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEI
EFWFALIKIITIIGLIITGIYMLMTGFVLPNDTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFINFVVLTSASSSSNSGIYSTSR
MVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVVLLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRK
HPERHEKSTFKMPGRRASVVMVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=363, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI258645169, Length=504, Percent_Identity=23.2142857142857, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI114326544, Length=430, Percent_Identity=22.7906976744186, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI114326550, Length=430, Percent_Identity=22.7906976744186, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI258614003, Length=505, Percent_Identity=23.5643564356436, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI258614005, Length=505, Percent_Identity=23.5643564356436, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4507047, Length=446, Percent_Identity=22.8699551569507, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI181337167, Length=363, Percent_Identity=22.038567493113, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=452, Percent_Identity=59.9557522123894, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=38.4449244060475, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=38.876404494382, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=39.3406593406593, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI48994972, Length=399, Percent_Identity=43.3583959899749, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=38.423645320197, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=36.9727047146402, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081708, Length=397, Percent_Identity=34.5088161209068, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789017, Length=404, Percent_Identity=31.9306930693069, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17532491, Length=427, Percent_Identity=24.3559718969555, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=401, Percent_Identity=25.4364089775561, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17533459, Length=377, Percent_Identity=25.7294429708223, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=424, Percent_Identity=33.7264150943396, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=432, Percent_Identity=30.787037037037, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=32.0276497695853, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=423, Percent_Identity=31.6784869976359, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=431, Percent_Identity=32.0185614849188, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=426, Percent_Identity=30.2816901408451, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=30, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=391, Percent_Identity=30.690537084399, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=29.2682926829268, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=416, Percent_Identity=26.4423076923077, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319608, Length=421, Percent_Identity=27.3159144893112, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=418, Percent_Identity=30.622009569378, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=406, Percent_Identity=29.5566502463054, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=26.9521410579345, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=390, Percent_Identity=28.974358974359, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=389, Percent_Identity=29.5629820051414, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=467, Percent_Identity=24.4111349036403, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24666159, Length=427, Percent_Identity=22.248243559719, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221512776, Length=427, Percent_Identity=22.248243559719, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24668806, Length=432, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356285, Length=432, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24668802, Length=432, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24667468, Length=410, Percent_Identity=23.4146341463415, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51618; Mature: 51618

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHEEECCCCEEEECCCHHHHHH
AITGFMLFFVMRALGEILLSNLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEIEFWFALIKIITIIGLIITGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMLMTGFVLPNDTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
HHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCC
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVVLTSASSSSNSGIYSTSRMVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVV
HHHEECCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRKHPERHEKSTFKMPGRRASVV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHCCCCCHHHHH
MVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTISKPSVDLHREEEPHLARNLSNRHLQLIAIGGTIGTGLFMGSGKAVSLAGPSILLIY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHEEECCCCEEEECCCHHHHHH
AITGFMLFFVMRALGEILLSNLQYRSFADFAGDYLGPCAQFFTGWTYWLCWIVTAVAEVV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSGYVSFWFPHLAPWIPALGLITILLILNLPTVRNFGEIEFWFALIKIITIIGLIITGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YMLMTGFVLPNDTQASIAHLWNHGGFFPNGSLGFIAGFQISVFAFVGIELVGTAAAEAEN
HHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHCC
PMRNLPKAINNIPIRIVLFYIGALFVIITVTPWNQVDPNSSPFVAMFSLAGIGIAAHFIN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FVVLTSASSSSNSGIYSTSRMVYGLATVGLAPKAFSKLSNRKVPVHALIFSCIFLLSSVV
HHHEECCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLYAGQSMIQVFTLVTTISALLFIFIWSIILVSYLQYRRKHPERHEKSTFKMPGRRASVV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHCCCCCHHHHH
MVFIFFAFVLWALTQEPDTLAAMKVTPLWFVLLGIAYWVMKLKQKQS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]