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The map label for this gene is mltA [H]

Identifier: 16273671

GI number: 16273671

Start: 132027

End: 132959

Strand: Direct

Name: mltA [H]

Synonym: HI0117

Alternate gene names: 16273671

Gene position: 132027-132959 (Clockwise)

Preceding gene: 16272087

Following gene: 16272088

Centisome position: 7.21

GC content: 38.26

Gene sequence:

>933_bases
GTGCCTGTTTCCTATATAGAAAACCAAAGTGCGGTAATAAATCAAGGCGATTTTTTAACACAGCTTTCCAATATAAAAAA
TTATTCAAGTAAACTTTCCACAAATTTTTACGATAATTATGAAAAGATTACAAATTGGGTTCTTTCTGGGGCAAATATTA
ATGAACTCACTCAATTTAATATCCAACCACAAATTATGCGTGGCTTTGATGGATTTCAAAATGTGCTGATGACAGGCTAT
TATTCGCCTATACTTTATGCTCGTCATTCCCCACAAGGTCAATTTAAAAATCCAATTTATCGTATGCCTGTAAAAAAACG
TCTAAGTCGAGCACAAATTTATGCGGGAGCATTAGCGGGAAAAAGATTAGAGTTAGCATATAGCGATTCAATGTTAGAAA
ACTTTTTACTTGGTGTACAAGGCAGTGGCTATGTAGATTTTGGCGATGGCAATCTTAACTATTTTGCTTACGCAGGACAA
AATGGTTACCCTTACACGGCTATCGGGCGTTTATTAGTAGAAGATGGCGAAATTCCAAAAGAAAAAATGTCTATTCAAGC
AATTCGAGAATGGGGTAATCGTAATCCCTCTCGTATACAAAGCTTGTTAGAACGCAATGAAGCTTATGTATTCTTTAAAA
ATGATCCAAGTGGCAAAGTGAAAGGCTCTGCGGGCGTTCCTCTTGTAGCAATGGCTTCAGTGGCATCAGATCGCAATATT
ATCCCATCTGGTTCTGTGCTTTTAGTCGAAGTACCCGACATTGATAATAACGGAAACTGGCTTGGCACACACAAATTACA
CTTAATGGTTGCACTTGATGTAGGCGGTGCAGTGAAAGGTCATCACTTTGACTTATATCGTGGTATCGGTGCTAGAGCAG
GACATATTGCAGGGCTTTCAAAACACTACGGTAGAGTATGGGTATTACGGTAA

Upstream 100 bases:

>100_bases
ACACAANAAACACTCAGATTCCAACCNCCTCAAATGGGAGTGATCCTCAACAATTCGGTGTGCAAAATATACCAATCGAA
CTTATCAGCAAACCGCTCTT

Downstream 100 bases:

>100_bases
TGGCTAGAATAGATAATTACGAACAACGCTTTGGTGGCATTGGACGACTTTATACGCCTGATAGCTTAGCACGCTTACGC
CAAGCGCATATTTGCGTAAT

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGY
YSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQ
NGYPYTAIGRLLVEDGEIPKEKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNI
IPSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR

Sequences:

>Translated_310_residues
MPVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGY
YSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQ
NGYPYTAIGRLLVEDGEIPKEKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNI
IPSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR
>Mature_309_residues
PVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFNIQPQIMRGFDGFQNVLMTGYY
SPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAGKRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQN
GYPYTAIGRLLVEDGEIPKEKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNII
PSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLSKHYGRVWVLR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=316, Percent_Identity=52.8481012658228, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 34465; Mature: 34333

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFN
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHEEEC
IQPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAG
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
KRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPK
CEEEEEECHHHHHHHHEECCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCH
EKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNI
HHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEHHHHCCCCCC
IPSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLS
CCCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEHHHHCCCCCCCHHHHHH
KHYGRVWVLR
HCCCEEEEEC
>Mature Secondary Structure 
PVSYIENQSAVINQGDFLTQLSNIKNYSSKLSTNFYDNYEKITNWVLSGANINELTQFN
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHEEEC
IQPQIMRGFDGFQNVLMTGYYSPILYARHSPQGQFKNPIYRMPVKKRLSRAQIYAGALAG
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
KRLELAYSDSMLENFLLGVQGSGYVDFGDGNLNYFAYAGQNGYPYTAIGRLLVEDGEIPK
CEEEEEECHHHHHHHHEECCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCH
EKMSIQAIREWGNRNPSRIQSLLERNEAYVFFKNDPSGKVKGSAGVPLVAMASVASDRNI
HHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEHHHHCCCCCC
IPSGSVLLVEVPDIDNNGNWLGTHKLHLMVALDVGGAVKGHHFDLYRGIGARAGHIAGLS
CCCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEHHHHCCCCCCCHHHHHH
KHYGRVWVLR
HCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]