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The map label for this gene is lldD [H]

Identifier: 16273624

GI number: 16273624

Start: 1822366

End: 1823511

Strand: Reverse

Name: lldD [H]

Synonym: HI1739.1

Alternate gene names: 16273624

Gene position: 1823511-1822366 (Counterclockwise)

Preceding gene: 16273625

Following gene: 16273623

Centisome position: 99.64

GC content: 43.54

Gene sequence:

>1146_bases
ATGATTATTTCATCAGCTAGCGATTATCGTGAAGCGGCGCGTCGCCGTGTTCCTCCCTTTATGTTCCATTATGCCGATGG
CGGTTCTTATGCCGAGCAAACACTTGCGCGTAATGTGAGTGATTTGGAAAATATTGCTTTAAGACAACGTGTCTTAAAAG
ATATGTCTGAATTGGATACTAGTATAGAATTATTTGGTGAAAAACTTTCAATGCCAACTATTCTTGCACCAGTTGGGGCG
TGCGGAATGTATGCGCGTCGTGGAGAAGTACAAGCAGCACAAGCGGCGGACAATAAAGGTGTGCCGTTTACCCTTTCAAC
AGTATCAATTTGTCCAATTGAAGAAGTCGCCCCTGCGATTAAGCGTCCAATGTGGTTTCAGCTTTATGTGTTAAAAGATC
GTGGTTTTATGAAAAACGCGCTTGAGCGTGCGAAAGCAGCAGGCTGTTCTACTTTAGTGTTTACGGTCGATATGCCTACT
CCAGGTGCACGTTATCGTGATATGCACTCAGGTATGAGCGGGCCTTACAAAGAAATTCGCCGTGTATTACAAGGCTTTAC
ACACCCATTCTGGGCGTATGATGTGGGTATCAAAGGCAAACCGCACACCTTGGGTAATGTTTCAACTTATATGGGTAGAC
AAATAGGTTTAGATGACTATATTGGCTGGCTAACAGAAAACTTTGATCCATCAATTTCGTGGAAAGATTTAGAGTGGATC
CGTGAGTTTTGGGAAGGTCCAATGGTCATTAAAGGTATTCTCGACCCTGAAGATGCGAAAGATGCGGTGCGTTTCGGTGC
TGATGGAATTGTTGTTTCAAATCACGGTGGCCGTCAGTTAGATGGCGTGCTTTCAAGTGCAAGAGCGTTGCCACCAATTG
CCGATGCAGTGAAAGGGGATATTAAAATTATTGCCGATTCAGGTATTCGCAATGGTTTAGACATAGTCCGTATGTTGGCA
TTAGGGGCAGATGCAACAATGTTAGGTCGAGCATTTGTTTATGCTTTAGGGGCAGAAGGTCGTCAAGGTGTTGAAAATAT
GCTCGACATTTTCAAAAAAGAGATGCACGTAGCGATGACATTAACCAGCAATCGTACTATTGCCGATATTAAACCAGAGG
CTTTGGTTGATCTAAGTAAACTTTAA

Upstream 100 bases:

>100_bases
GATCTAGTTCTCAAAATAATTATGATTTTTATTGAATTTGTTAAAATAGTGTTATAATACCTCTCAGGTTTCTCACTATT
TTATTGAATAAGAGGTAAAA

Downstream 100 bases:

>100_bases
TTTATAAATTGAGATCAAAAATCAACCATTTGTTGGCGGAATTATGTATTTTACGTATGTATTTTCAACAAACGGTCGAG
TTTTTCAAAAATTTTTGCAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDTSIELFGEKLSMPTILAPVGA
CGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAIKRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPT
PGARYRDMHSGMSGPYKEIRRVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWI
REFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGDIKIIADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMTLTSNRTIADIKPEALVDLSKL

Sequences:

>Translated_381_residues
MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDTSIELFGEKLSMPTILAPVGA
CGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAIKRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPT
PGARYRDMHSGMSGPYKEIRRVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWI
REFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGDIKIIADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMTLTSNRTIADIKPEALVDLSKL
>Mature_381_residues
MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDTSIELFGEKLSMPTILAPVGA
CGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAIKRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPT
PGARYRDMHSGMSGPYKEIRRVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWI
REFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGDIKIIADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMTLTSNRTIADIKPEALVDLSKL

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=365, Percent_Identity=33.6986301369863, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI54234014, Length=382, Percent_Identity=34.0314136125654, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7705393, Length=382, Percent_Identity=34.0314136125654, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=75.7978723404255, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI193208036, Length=381, Percent_Identity=32.8083989501312, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.3943661971831, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=385, Percent_Identity=30.6493506493506, Blast_Score=172, Evalue=7e-44,
Organism=Drosophila melanogaster, GI78707188, Length=381, Percent_Identity=34.9081364829396, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281363140, Length=381, Percent_Identity=34.9081364829396, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI78707190, Length=381, Percent_Identity=34.9081364829396, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41966; Mature: 41966

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDT
CCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIELFGEKLSMPTILAPVGACGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAI
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPTPGARYRDMHSGMSGPYKEIR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCHHHHHH
RVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWI
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHCCCC
IKIIADSGIRNGLDIVRMLALGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEE
LTSNRTIADIKPEALVDLSKL
EECCCEEECCCHHHHHHHHCC
>Mature Secondary Structure
MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDT
CCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIELFGEKLSMPTILAPVGACGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAI
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPTPGARYRDMHSGMSGPYKEIR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCHHHHHH
RVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWI
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHCCCC
IKIIADSGIRNGLDIVRMLALGADATMLGRAFVYALGAEGRQGVENMLDIFKKEMHVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEE
LTSNRTIADIKPEALVDLSKL
EECCCEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA