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The map label for this gene is rnb [H]

Identifier: 16273617

GI number: 16273617

Start: 1809215

End: 1811194

Strand: Reverse

Name: rnb [H]

Synonym: HI1733

Alternate gene names: 16273617

Gene position: 1811194-1809215 (Counterclockwise)

Preceding gene: 30995476

Following gene: 16273668

Centisome position: 98.96

GC content: 42.98

Gene sequence:

>1980_bases
ATGTTTCAAGATAATCCTCTACTCGCACAACTTAAACAACAAATCCACGACAGCAAAGAACAGGTTGAGGGCGTGGTAAA
AAGCACAGATAAAGCCTACGGTTTTTTAGAGTGCGATAAAAAAACCTATTTCATCGCACCGCCATCAATGAAAAAAGTGA
TGCATGGCGACAAAATCAAAGCCACTATTGAAAAACAAGGCGACAAAGAACAAGCCGAGCCAGAAGCCTTAATTGAGCCA
ATGCTCACACGTTTTATCGCAAAAGTGCGGTTCAATAAAGACAAGAAATTACAAGTGCTGGTGGATCACCCAAGTATTAA
TCAACCCATTGGCGCACAACAGGCGAAATCGGTAAAAGAAGAATTGCAAGAGGGCGACTGGGTCGTCGCAAATTTAAAAA
CCCATCCATTACGTGACGATCGCTTTTTCTACGCCACAATTAATCAACTTATTTGCCGAGCTGACGATGAATTAGCCCCT
TGGTGGGTCACATTGGCACGCCACGAACAATCGCGCTATCCCGTGCGAGGCGCAGAACCTTATGAAATGTTAGATCAAAA
AACACGCGAAAATCTGACCGCACTTCATTTTGTAACCATTGATTCCGAAAGCACAATGGATATGGACGACGCCTTATATA
TCGAACCCATAGCACAAAACAGCACACAAACAGGCTGGAAATTAGTGGTCGCCATTGCTGACCCAACCGCTTACATCGCC
TTAGATTCTCAAATAGAACAAGAAGCCAAACAGCGTTGCTTCACAAATTATTTACCGGGCTTTAACATTCCAATGTTACC
CCGTGAATTATCTGATGAATTATGTTCCTTAATCGCCAATGAAACCCGCCCCGCGCTTGTCTGTTATATCGAAACCGATC
TTACAGGCAACATCACAGCCAAACCGCATTTTGTTTCCGCTTATGTTCAATCTAAAGCCAAACTGGCTTACAACAAAGTG
TCGGATTATTTAGAACAGGCAGACAATGCATGGCAGCCAGAAATGCCAGAAACAGCACAACAAATTCACTGGCTACATCA
ATTTACCAAAGCTCGCATTCAATGGCGCAAAACCCATTCCTTATTCTTTAAAGAAAAACCCGATTATGCCTTTGTGCTGG
CAGAAAACGGCAAAGTACAAGAAATCAAAGCAGAATATCGCCGTATTGCCAATCAAATTGTGGAAGAAGCAATGATTATT
GCCAACATCTGCGCCGCCCAATTTTTACACGAACAGGCAAAAACAGGCATTTTCAACACCCATAGCGGTTTTGATAAAAA
ATTCTTAGAGAACGCACACAATTTCTTAATGGCAAATTTAGCCAATGAACAAAATCAAACTGAACTGGCAGAACGTTATT
CAGTAGAAAACTTAGCAACCTTAAACGGCTATTGCCAAATGCGCCACGATATTGAACCCATCGAAAGCGATTATTTAGAA
CTGCGTTTACGCCGTTATTTAACTTTCGCCGAATTTAAATCAGAATTAGCACCGCACTTTGGGCTGGGGCTAGAGGGTTA
CGCCACTTGGACATCGCCCATCCGCAAATATTCAGATATGGTTAATCATCGCTTAATCAAAGCCGTGCTGGCAAAACAGC
CTTATGAAAAACCACAAAATGACGTGTTGGCACGTTTGCAAGAGGCTCGCCGCCAAAATCGCCTCGTAGAACGTGATATT
GCCGATTGGCTATATTGCCGTTATCTTGCTGACAAAGTGGCATCAAATGCTGAATTTGAGGCGGAAGTGCAAGATGTAAT
GCGTGCAGGCTTACGCGTACAACTGCTCGAAAATGGTGCATCGCTATTTATTCCTGCCGCCACGCTGCACAACAACAAAG
AAGAAATACAACTAAACCCTGACGAACTTGCCCTCTATATAAAAGGCGAACGCACTTACAAAATAGGCGACATGGTAAAA
GTGAAACTCACAGAAGTGAAAGAAGCCACACGCAGTATTGTGGGCGAAATACTTCAATAA

Upstream 100 bases:

>100_bases
GAATTAGGCGAAGAATAATTTTTCTTACATTCTTTTTTAGGCAGGCTTTTCAGTCTGCCTTTTCTCTTTTTTAAAATAAT
AACGATGTTTCAAAATAACT

Downstream 100 bases:

>100_bases
ATTGCCGTTCCCTTTTGCCTAAAACCTGCTTTCAATGCCAGAAAGCAGGTTTTTCTTTTAATTTTTACCGCACTTTTCAA
CAAAAAACACCTAAAATGGG

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPEALIEP
MLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQLICRADDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITAKPHFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYAFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVK
VKLTEVKEATRSIVGEILQ

Sequences:

>Translated_659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPEALIEP
MLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQLICRADDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITAKPHFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYAFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVK
VKLTEVKEATRSIVGEILQ
>Mature_659_residues
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIKATIEKQGDKEQAEPEALIEP
MLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKEELQEGDWVVANLKTHPLRDDRFFYATINQLICRADDELAP
WWVTLARHEQSRYPVRGAEPYEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITAKPHFVSAYVQSKAKLAYNKV
SDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHSLFFKEKPDYAFVLAENGKVQEIKAEYRRIANQIVEEAMII
ANICAAQFLHEQAKTGIFNTHSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQNDVLARLQEARRQNRLVERDI
ADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGASLFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVK
VKLTEVKEATRSIVGEILQ

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=352, Percent_Identity=25.5681818181818, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI190014623, Length=352, Percent_Identity=25.8522727272727, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI134288890, Length=440, Percent_Identity=25, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1787542, Length=657, Percent_Identity=49.4672754946728, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=675, Percent_Identity=27.5555555555556, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17553506, Length=376, Percent_Identity=24.7340425531915, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI212645896, Length=471, Percent_Identity=24.203821656051, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324552, Length=432, Percent_Identity=23.6111111111111, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24649634, Length=367, Percent_Identity=25.6130790190736, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24654592, Length=447, Percent_Identity=24.6085011185682, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19922976, Length=447, Percent_Identity=24.6085011185682, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24654597, Length=447, Percent_Identity=24.6085011185682, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 75783; Mature: 75783

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIK
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHCEEEEECCEEEEECCCHHHHHHCCCHHE
ATIEKQGDKEQAEPEALIEPMLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKE
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
ELQEGDWVVANLKTHPLRDDRFFYATINQLICRADDELAPWWVTLARHEQSRYPVRGAEP
HHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCH
YEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEE
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITA
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
KPHFVSAYVQSKAKLAYNKVSDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFFKEKPDYAFVLAENGKVQEIKAEYRRIANQIVEEAMIIANICAAQFLHEQAKTGIFNT
HHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVLARLQEARRQNRLVERDIADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCC
SLFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVKVKLTEVKEATRSIVGEILQ
CEEEEHHHHCCCCCCEEECHHHEEEEEECCCEEECCCEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQDNPLLAQLKQQIHDSKEQVEGVVKSTDKAYGFLECDKKTYFIAPPSMKKVMHGDKIK
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHCEEEEECCEEEEECCCHHHHHHCCCHHE
ATIEKQGDKEQAEPEALIEPMLTRFIAKVRFNKDKKLQVLVDHPSINQPIGAQQAKSVKE
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
ELQEGDWVVANLKTHPLRDDRFFYATINQLICRADDELAPWWVTLARHEQSRYPVRGAEP
HHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCH
YEMLDQKTRENLTALHFVTIDSESTMDMDDALYIEPIAQNSTQTGWKLVVAIADPTAYIA
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCEEEE
LDSQIEQEAKQRCFTNYLPGFNIPMLPRELSDELCSLIANETRPALVCYIETDLTGNITA
ECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
KPHFVSAYVQSKAKLAYNKVSDYLEQADNAWQPEMPETAQQIHWLHQFTKARIQWRKTHS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFFKEKPDYAFVLAENGKVQEIKAEYRRIANQIVEEAMIIANICAAQFLHEQAKTGIFNT
HHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HSGFDKKFLENAHNFLMANLANEQNQTELAERYSVENLATLNGYCQMRHDIEPIESDYLE
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LRLRRYLTFAEFKSELAPHFGLGLEGYATWTSPIRKYSDMVNHRLIKAVLAKQPYEKPQN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVLARLQEARRQNRLVERDIADWLYCRYLADKVASNAEFEAEVQDVMRAGLRVQLLENGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCC
SLFIPAATLHNNKEEIQLNPDELALYIKGERTYKIGDMVKVKLTEVKEATRSIVGEILQ
CEEEEHHHHCCCCCCEEECHHHEEEEEECCCEEECCCEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA