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The map label for this gene is pepA [H]

Identifier: 16273592

GI number: 16273592

Start: 1776575

End: 1778050

Strand: Direct

Name: pepA [H]

Synonym: HI1705

Alternate gene names: 16273592

Gene position: 1776575-1778050 (Clockwise)

Preceding gene: 16273588

Following gene: 16273602

Centisome position: 97.07

GC content: 39.7

Gene sequence:

>1476_bases
ATGAAATATCAAGCAAAAAATACCGCACTTTCTCAAGCCACTGATTGCATTGTTTTAGGCGTCTATGAAAATAATAAATT
TTCAAAAAGTTTTAATGAAATCGATCAATTAACCCAAGGTTATTTAAACGATTTAGTCAAATCAGGTGAGCTCACTGGCA
AATTAGCCCAAACCGTTTTACTTCGTGATCTTCAAGGTTTATCTGCTAAACGCCTATTAATCGTTGGCTGTGGCAAAAAA
GGAGAACTCACAGAGCGTCAATATAAACAAATCATCCAAGCTGTATTAAAGACACTAAAAGAAACCAACACGCGTGAAGT
CATTTCTTATTTAACTGAAATTGAATTAAAAGATCGCGATCTTTATTGGAATATCCGCTTTGCCATTGAAACGATTGAAC
ACACCAATTATCAATTTGATCATTTCAAATCTCAAAAAGCAGAAACCTCTGTTTTAGAATCTTTCATCTTCAATACGGAT
TGTGCTCAAGCACAACAAGCTATTTCTCACGCCAATGCCATTAGCTCAGGCATAAAAGCAGCACGCGACATCGCAAATAT
GCCACCAAATATTTGTAATCCAGCTTATCTTGCTGAGCAAGCAAAAAATTTAGCAGAAAATTCTACCGCACTTTCATTGA
AAGTTGTGGATGAAGAAGAAATGGCAAAACTTGGAATGAACGCTTATCTTGCCGTCTCAAAAGGCTCTGAAAACCGTGCT
TATATGTCTGTTTTAACATTCAATAATGCGCCAGATAAAAACGCCAAACCCATTGTACTTGTAGGCAAGGGATTAACCTT
TGATGCAGGCGGTATTTCACTTAAACCCGCCGCAGATATGGATGAAATGAAATATGATATGTGCGGTGCAGCCTCTGTCT
TCGGCACAATGAAAACCATTGCACAGTTGAACTTGCCATTAAACGTTATTGGTGTTTTAGCAGGTTGTGAAAATCTGCCA
GATGGCAATGCTTATCGCCCAGGCGATATTCTTACCACTATGAATGGTTTAACCGTAGAAGTTCTTAATACTGATGCAGA
AGGTCGATTAGTGCTTTGTGATACCCTTACTTATGTTGAGCGTTTTGAACCTGAGCTTGTTATTGATGTTGCAACCTTGA
CTGGTGCTTGTGTGGTTGCACTAGGGCAACACAATAGCGGCTTAGTTTCTACAGATAACAATCTTGCCAATGCACTACTC
CAAGCCGCAACAGAAACCACTGACAAAGCGTGGCGTTTACCATTAAGCGAAGAATATCAAGAGCAACTTAAATCGCCTTT
CGCCGACCTTGCCAACATTGGTGGTCGCTGGGGGGGCGCAATTACAGCGGGTGCATTTTTGTCTAATTTCACGAAAAAAT
ATCGCTGGGCACATTTAGACATCGCTGGTACAGCTTGGTTACAAGGTGCAAATAAAGGTGCAACAGGTCGCCCTGTTTCG
CTATTAACCCAATTTTTGATTAATCAGGTTAAATAA

Upstream 100 bases:

>100_bases
CGTTTGTTTTTCTAAATCTAAAACGGAGGAAAACTGGATAAAATCGGTCGCATATGATAACTTATTTTCGCTGAATTAAA
CAGAAATTTAAGGACAACAA

Downstream 100 bases:

>100_bases
CCACAAAACTGGCACACGTTGCACCTTTAAATCGATTACTCTGCTAGTTCGGTTTGCTCGTGTGCCATCAGTTCCTGACC
CACATCATCAAGCAAACTTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVLLRDLQGLSAKRLLIVGCGKK
GELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRDLYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTD
CAQAQQAISHANAISSGIKAARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRA
YMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTIAQLNLPLNVIGVLAGCENLP
DGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALL
QAATETTDKAWRLPLSEEYQEQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVS
LLTQFLINQVK

Sequences:

>Translated_491_residues
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVLLRDLQGLSAKRLLIVGCGKK
GELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRDLYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTD
CAQAQQAISHANAISSGIKAARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRA
YMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTIAQLNLPLNVIGVLAGCENLP
DGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALL
QAATETTDKAWRLPLSEEYQEQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVS
LLTQFLINQVK
>Mature_491_residues
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVLLRDLQGLSAKRLLIVGCGKK
GELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRDLYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTD
CAQAQQAISHANAISSGIKAARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRA
YMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTIAQLNLPLNVIGVLAGCENLP
DGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVERFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALL
QAATETTDKAWRLPLSEEYQEQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVS
LLTQFLINQVK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=509, Percent_Identity=34.3811394891945, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI47155554, Length=319, Percent_Identity=31.3479623824451, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1790710, Length=496, Percent_Identity=57.0564516129032, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=40.9375, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=30.6666666666667, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17565172, Length=223, Percent_Identity=29.1479820627803, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI20129969, Length=496, Percent_Identity=28.4274193548387, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=33.9622641509434, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=33.6477987421384, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21355645, Length=509, Percent_Identity=27.1119842829077, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24662223, Length=509, Percent_Identity=27.1119842829077, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24662227, Length=501, Percent_Identity=26.5469061876248, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI161077148, Length=315, Percent_Identity=31.7460317460317, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20130057, Length=315, Percent_Identity=31.7460317460317, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129963, Length=498, Percent_Identity=27.3092369477912, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19922386, Length=319, Percent_Identity=33.2288401253918, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357381, Length=318, Percent_Identity=31.7610062893082, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=31.7610062893082, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=31.7610062893082, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646701, Length=249, Percent_Identity=28.9156626506024, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=249, Percent_Identity=28.9156626506024, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=249, Percent_Identity=28.9156626506024, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53530; Mature: 53530

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVL
CCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LRDLQGLSAKRLLIVGCGKKGELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRD
HHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEECCC
LYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTDCAQAQQAISHANAISSGIKA
EEEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCEEEEEECCCCCCE
YMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTI
EEEEEEECCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
AQLNLPLNVIGVLAGCENLPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVE
HHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEHHHHHHH
RFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALLQAATETTDKAWRLPLSEEYQ
HCCCCEEEEEHHHCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHCCCHHEECCCCHHHH
EQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVS
HHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECHHHHHCCCCCCCCCCCHH
LLTQFLINQVK
HHHHHHHHHCC
>Mature Secondary Structure
MKYQAKNTALSQATDCIVLGVYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTVL
CCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LRDLQGLSAKRLLIVGCGKKGELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRD
HHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEECCC
LYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTDCAQAQQAISHANAISSGIKA
EEEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCEEEEEECCCCCCE
YMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKTI
EEEEEEECCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
AQLNLPLNVIGVLAGCENLPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDTLTYVE
HHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCEEEEHHHHHHH
RFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALLQAATETTDKAWRLPLSEEYQ
HCCCCEEEEEHHHCCEEEEEECCCCCCCEECCCHHHHHHHHHHHHCCCHHEECCCCHHHH
EQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVS
HHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECHHHHHCCCCCCCCCCCHH
LLTQFLINQVK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA