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The map label for this gene is modE

Identifier: 16273581

GI number: 16273581

Start: 1764185

End: 1764952

Strand: Direct

Name: modE

Synonym: HI1694

Alternate gene names: 16273581

Gene position: 1764185-1764952 (Clockwise)

Preceding gene: 16273577

Following gene: 16273588

Centisome position: 96.4

GC content: 41.02

Gene sequence:

>768_bases
ATGAAAAACACCGAAATTTTACTCACCATTAAACTTCAACAAGCACTTTTTATCGATCCAAAACGAGTTCGTTTACTCAA
AGAAATTCAACAATGCGGTTCAATTAATCAAGCTGCGAAAAATGCCAAAGTGAGCTATAAAAGTGCGTGGGATCATTTAG
AAGCCATGAATAAAATCAGCCCTCGCCCATTGCTGGAACGAAATACAGGTGGAAAAAATGGCGGAGGCACGGCACTTACT
ACTTATGCCGAGCGTTTGCTCCAACTTTATGATTTATTAGAACGTACGCAAGAACACGCGTTTCATATTCTACAAGATGA
ATCCGTACCGTTAGATAGTTTACTCACGGCAACCGCACGTTTTTCTTTACAAAGTAGCGCACGCAATCAATTTTTTGGGC
GAGTGGCACAACAACGCATTATTGACTCTCGTTGCGTTGTGGATGTGAATGTGCAAGGATTACCAACGCCATTGCAAGTT
TCTATTACCACAAAAAGCTCGGCTCGTTTGAAACTCATTACGGAAAAAGAAGTGATGCTGATGTTCAAGGCTCCTTGGGT
AAAAATCAGTGAACAACCATTAGCAAATCAACCGAATCAGTTCCCCGTAAATATCAAATCACTCAATGAAGAGGAAGCCA
TCCTTCAATTTGCTGAAAGCAACATTGAATTTTGTGCCACAGTCCACCAGCCAAATCAATGGCAAATCGAGCAACAGGTT
TGGATTCACATTGATCAAGAGCAAATTATTTTAGCGACGCTGGGGTAA

Upstream 100 bases:

>100_bases
ATATATTGAAATAAATAACAATCATATAGCAAAAGAAAAATTATTTAGTAAAATATATAACGCTTAGGCTTACCACTTAG
GATTACTTAGGAACAGCAAA

Downstream 100 bases:

>100_bases
TTCAGAGATATAATACGTAAATTCAATACTTATATTATTGTTTTCTGAACTAAAATAACCTTAAATCAAACAAAATTTTA
AATAAAATATTTAATTTCAT

Product: molybdenum transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKISPRPLLERNTGGKNGGGTALT
TYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATARFSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQV
SITTKSSARLKLITEKEVMLMFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQV
WIHIDQEQIILATLG

Sequences:

>Translated_255_residues
MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKISPRPLLERNTGGKNGGGTALT
TYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATARFSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQV
SITTKSSARLKLITEKEVMLMFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQV
WIHIDQEQIILATLG
>Mature_255_residues
MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKISPRPLLERNTGGKNGGGTALT
TYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATARFSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQV
SITTKSSARLKLITEKEVMLMFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQV
WIHIDQEQIILATLG

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family

Homologues:

Organism=Escherichia coli, GI1786976, Length=246, Percent_Identity=45.1219512195122, Blast_Score=177, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MODE_HAEIN (P45324)

Other databases:

- EMBL:   M94855
- EMBL:   L42023
- PIR:   B64175
- RefSeq:   NP_439836.1
- ProteinModelPortal:   P45324
- GeneID:   950754
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1694
- NMPDR:   fig|71421.1.peg.1607
- TIGR:   HI_1694
- HOGENOM:   HBG405634
- OMA:   HIARRPQ
- ProtClustDB:   CLSK870231
- BioCyc:   HINF71421:HI_1694-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005763
- TIGRFAMs:   TIGR00637
- TIGRFAMs:   TIGR00638

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE; SSF50331 MOP_like

EC number: NA

Molecular weight: Translated: 28899; Mature: 28899

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKIS
CCCCEEEEEEEECHHHCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCC
PRPLLERNTGGKNGGGTALTTYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
FSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQVSITTKSSARLKLITEKEVML
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEECCEEEE
MFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQV
EEECCCEEECCCCCCCCCCCCCEEHCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEE
WIHIDQEQIILATLG
EEEECCCEEEEEECC
>Mature Secondary Structure
MKNTEILLTIKLQQALFIDPKRVRLLKEIQQCGSINQAAKNAKVSYKSAWDHLEAMNKIS
CCCCEEEEEEEECHHHCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCC
PRPLLERNTGGKNGGGTALTTYAERLLQLYDLLERTQEHAFHILQDESVPLDSLLTATAR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
FSLQSSARNQFFGRVAQQRIIDSRCVVDVNVQGLPTPLQVSITTKSSARLKLITEKEVML
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEECCEEEE
MFKAPWVKISEQPLANQPNQFPVNIKSLNEEEAILQFAESNIEFCATVHQPNQWQIEQQV
EEECCCEEECCCCCCCCCCCCCEEHCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEE
WIHIDQEQIILATLG
EEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 9325422