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The map label for this gene is moaE

Identifier: 16273560

GI number: 16273560

Start: 1742950

End: 1743402

Strand: Reverse

Name: moaE

Synonym: HI1673

Alternate gene names: 16273560

Gene position: 1743402-1742950 (Counterclockwise)

Preceding gene: 16273561

Following gene: 16273557

Centisome position: 95.26

GC content: 38.85

Gene sequence:

>453_bases
ATGACGGATATTCAAATTGCGGTACAAGAACAGCCTTTTGATCAAAATGCCGTTTACCAATGGCTTTCTGAGCAACATTC
AATTGGCGCAACGGTTATTTTTGTGGGTAAAGTACGCGATCTTAATTTAGGCGATGAGGTATCCAGTTTATACTTAGAAC
ATTATCCCGCAATGACTGAAAAAGCGTTGAATGAAATTGTTGCACAAGCGAAAGTGCGTTGGGATATTCAACGTGTATCG
GTAATTCATCGTGTTGGGCTTTTACAAACTGGCGATGAAATTGTTTTAGTGGGGGTAAGTTCCGCACATCGTGGAGATGC
TTATCACGCCAATGAATTCATTATGGATTTTTTAAAATCTAAAGCACCATTTTGGAAAAAAGAACAAACCAATCAAGGCG
AGCGTTGGATTGAAGCAAGAGAGAGTGATAAAGAAGCATTAGAAAAATGGTAA

Upstream 100 bases:

>100_bases
TAAACTTTTAGTGGCAATTAATCAAACCTTAATGCCTTTAGAAAGTGCGGTAAAAAATGGCGATGAAATTGCCTTTTTCC
CACCAGTAACAGGGGGCTAA

Downstream 100 bases:

>100_bases
TAGCTTATCTGCACCCTAATTCATTAAGGTGCAGATTAAATATTTTCATTTATGTTATTTTGATAACGCGCCACTTCCCC
AAGTTTGCACTTCTTCAGGG

Product: molybdopterin converting factor subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTDIQIAVQEQPFDQNAVYQWLSEQHSIGATVIFVGKVRDLNLGDEVSSLYLEHYPAMTEKALNEIVAQAKVRWDIQRVS
VIHRVGLLQTGDEIVLVGVSSAHRGDAYHANEFIMDFLKSKAPFWKKEQTNQGERWIEARESDKEALEKW

Sequences:

>Translated_150_residues
MTDIQIAVQEQPFDQNAVYQWLSEQHSIGATVIFVGKVRDLNLGDEVSSLYLEHYPAMTEKALNEIVAQAKVRWDIQRVS
VIHRVGLLQTGDEIVLVGVSSAHRGDAYHANEFIMDFLKSKAPFWKKEQTNQGERWIEARESDKEALEKW
>Mature_149_residues
TDIQIAVQEQPFDQNAVYQWLSEQHSIGATVIFVGKVRDLNLGDEVSSLYLEHYPAMTEKALNEIVAQAKVRWDIQRVSV
IHRVGLLQTGDEIVLVGVSSAHRGDAYHANEFIMDFLKSKAPFWKKEQTNQGERWIEARESDKEALEKW

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=109, Percent_Identity=34.8623853211009, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787003, Length=150, Percent_Identity=58, Blast_Score=190, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17509279, Length=135, Percent_Identity=32.5925925925926, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21356259, Length=134, Percent_Identity=33.5820895522388, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_HAEIN (P45308)

Other databases:

- EMBL:   L42023
- PIR:   H64135
- RefSeq:   NP_439815.1
- ProteinModelPortal:   P45308
- SMR:   P45308
- GeneID:   950861
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1673
- NMPDR:   fig|71421.1.peg.1586
- TIGR:   HI_1673
- HOGENOM:   HBG460564
- OMA:   GAVACFV
- ProtClustDB:   CLSK870173
- BioCyc:   HINF71421:HI_1673-MONOMER
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 17213; Mature: 17081

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIQIAVQEQPFDQNAVYQWLSEQHSIGATVIFVGKVRDLNLGDEVSSLYLEHYPAMTE
CCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECEECCCCCHHHHHHHHHHCCCHHH
KALNEIVAQAKVRWDIQRVSVIHRVGLLQTGDEIVLVGVSSAHRGDAYHANEFIMDFLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHC
KAPFWKKEQTNQGERWIEARESDKEALEKW
CCCCCCCCCCCCCHHHHHHHCCHHHHHHCC
>Mature Secondary Structure 
TDIQIAVQEQPFDQNAVYQWLSEQHSIGATVIFVGKVRDLNLGDEVSSLYLEHYPAMTE
CCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECEECCCCCHHHHHHHHHHCCCHHH
KALNEIVAQAKVRWDIQRVSVIHRVGLLQTGDEIVLVGVSSAHRGDAYHANEFIMDFLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHC
KAPFWKKEQTNQGERWIEARESDKEALEKW
CCCCCCCCCCCCCHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800