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The map label for this gene is sapA

Identifier: 16273527

GI number: 16273527

Start: 1702963

End: 1704660

Strand: Direct

Name: sapA

Synonym: HI1638

Alternate gene names: 16273527

Gene position: 1702963-1704660 (Clockwise)

Preceding gene: 16273525

Following gene: 16273528

Centisome position: 93.05

GC content: 35.16

Gene sequence:

>1698_bases
ATGTTACGTCTAAATCTGAGATTTTTATCTTTTCTGCTCTGTATAATCCAAAGTGTAGAATTACAGGCTGCGCCAAGTGT
TCCAACATTTTTAACTGAAAATGGCTTAACTTATTGCACCCACGCTTCAGGTTTTTCATTTAATCCGCAAACGGCAGATG
CAGGAACCAGTATGAATGTGGTCACGGAACAAATTTATAACAAATTATTTGATATAAAAAATCACAGTGCAACATTAACA
CCAATGCTGGCGCAATCTTATTCCATTTCAGCTGATGGTAAAGAAATTTTATTAAATTTACGTCACGGCGTAAAATTTCA
CCAAACCCCTTGGTTTACCCCAACACGTGATTTTAACGCTGAAGACGTAGTATTTTCGATTAATCGTGTATTAGGGGGGC
ATAATACTTATTTACCAACCTTAGCAGAGACGAATGTTACCTATAGTAATCCACAATATAGAGTGTTTCACGAACAAGCA
AGAAAAGTGCGTTTTCCTTATTTTGATAGCATTAAACTTAACGAAAAAATCAAATCTGTGACCGCACTTTCGCCTTATCA
AGTAAAAATTGAATTATTTGCACCAGATTCCTCCATCTTGTCTCATCTTGCCAGCCAGTATGCCATTATTTTTTCACAAG
AATATGCCTATCAATTAAGTGCAGATGACAACCTTGCTCAATTAGATACCCACCCAGTAGGAACAGGGCCTTATCAAGTA
AAAGATTATGTATATAACCAATATGTTCGCTTAGTGCGCAATGAAAATTATTGGAAAAAAGAAGCCAAGATAGAACATAT
TATTGTGGATCTTTCTACTGATCGCAGCGGACGTTTAGTCAAATTTTTCAATAATGAATGTCAAATCGCCTCTTATCCTG
AAGTAAGCCAAATTGGCTTATTAAAAAATGATGACAAACATTATTATATGCAATCTACTGATGGTATGAATTTAGCCTAT
TTAGCGTTTAATTTTGATAAGCCATTAATGCGAGATCACGAAATCCGTGCCGCTATTTCACAAAGTTTAAACCGAGCTCG
AATCATTCATAGCATTTACCATAACACAGCAACTGTTGCTAATAACATTATTCCTGAAGTATCTTGGGCTTCAAGTGTCA
ATACGCCAGAATTTGAGTTTGATTACAATCCCAAAATCGCCAAAAATAAATTAGCAGATAAAAACCTTTTGTTAAATTTA
TGGGTAATTAATGAAGAACAAGTCTATAATCCTGCACCTTTTAAAATAGCTGAAATGATAAAATGGGATTTAGCTCAAGC
GGGTGTGAAAGTTAAAGTGCGTGCCGTAACTCGTCCATTTTTAACTGCGCAATTACGCAATCAATCGGAAAATTATGATT
TGATTCTATCTGGTTGGTTAGCTGGTAATCTTGATCCTGATGGTTTTATGCGTCCAATTTTAAGCTGTGGAACAAAAAAT
GAACTCACTAATTTATCTAATTGGTGTAATGAAGAATTTGATCAATTTATGGATCGTGCCATTACCACCTCACATTTAAG
TTCACGCGCAAAAGCCTATAATGAAGCCCAAGAACTCGTTTTACGTGAATTACCCATTATTCCTATTGCCAATGTAAAAC
GAATTTTAGTCGCAAATAGTCGTGTGAAAGGAGTAAAAATGACGCCTTTTGGTAGCTTAGATTTTTCCACCTTATATTTT
ATTCAGGAGAAATACTAA

Upstream 100 bases:

>100_bases
GATTGATTTCCTTTTGAACCCGATTAAACATTCAATATCCTAGCCATTTTTACTAATATGCCTTACAATTTGACACATAA
TTTATCACAATGCATTTGTT

Downstream 100 bases:

>100_bases
TGTTATGGTCGGTTCTTCGCCATATTCTGTGGGTGGCATTATTATTACTCGTATTATCGCTATTAGGCTTTGTCATTTTA
TTGCGCGATCCTCTTAATGC

Product: anti peptide resistance ABC transporter periplasmic protein

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNVVTEQIYNKLFDIKNHSATLT
PMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNAEDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQA
RKVRFPYFDSIKLNEKIKSVTALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQV
KDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGLLKNDDKHYYMQSTDGMNLAY
LAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVANNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNL
WVINEEQVYNPAPFKIAEMIKWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKN
ELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANSRVKGVKMTPFGSLDFSTLYF
IQEKY

Sequences:

>Translated_565_residues
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNVVTEQIYNKLFDIKNHSATLT
PMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNAEDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQA
RKVRFPYFDSIKLNEKIKSVTALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQV
KDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGLLKNDDKHYYMQSTDGMNLAY
LAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVANNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNL
WVINEEQVYNPAPFKIAEMIKWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKN
ELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANSRVKGVKMTPFGSLDFSTLYF
IQEKY
>Mature_565_residues
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNVVTEQIYNKLFDIKNHSATLT
PMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNAEDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQA
RKVRFPYFDSIKLNEKIKSVTALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQV
KDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGLLKNDDKHYYMQSTDGMNLAY
LAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVANNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNL
WVINEEQVYNPAPFKIAEMIKWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKN
ELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANSRVKGVKMTPFGSLDFSTLYF
IQEKY

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family

Homologues:

Organism=Escherichia coli, GI1787551, Length=558, Percent_Identity=37.9928315412186, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789966, Length=561, Percent_Identity=29.0552584670232, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1787052, Length=492, Percent_Identity=21.5447154471545, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1787762, Length=516, Percent_Identity=23.062015503876, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789887, Length=498, Percent_Identity=21.6867469879518, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081878, Length=365, Percent_Identity=22.7397260273973, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAPA_HAEIN (P45285)

Other databases:

- EMBL:   L42023
- PIR:   A64134
- RefSeq:   NP_439780.1
- ProteinModelPortal:   P45285
- GeneID:   950479
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1638
- NMPDR:   fig|71421.1.peg.1552
- TIGR:   HI_1638
- HOGENOM:   HBG688042
- OMA:   CTHASGF
- ProtClustDB:   CLSK870293
- BioCyc:   HINF71421:HI_1638-MONOMER
- InterPro:   IPR000914

Pfam domain/function: PF00496 SBP_bac_5

EC number: NA

Molecular weight: Translated: 64505; Mature: 64505

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNV
CEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHH
VTEQIYNKLFDIKNHSATLTPMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNA
HHHHHHHHHHCCCCCCCEECHHHHCCEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCC
EDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQARKVRFPYFDSIKLNEKIKSV
CHHHEEHHHHHCCCCCCCCCEECCCCEECCCCEEEEHHHHHEECCCCCCCEEHHHHHHHH
TALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQV
HCCCCEEEEEEEECCCHHHHHHHHHHEEEEEEECEEEEECCCCCCCCCCCCCCCCCCHHH
KDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGL
HHHHHHHHHHHHCCCCCHHHHCCEEEEEEEECCCCCCCEEEEECCCCEECCCCCHHHCCC
LKNDDKHYYMQSTDGMNLAYLAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVA
EECCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNLWVINEEQVYNPAPFKIAEMI
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCEEEEEEEECHHHCCCCCCHHHHHHH
KWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKN
HHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCH
ELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
RVKGVKMTPFGSLDFSTLYFIQEKY
CCCCEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MLRLNLRFLSFLLCIIQSVELQAAPSVPTFLTENGLTYCTHASGFSFNPQTADAGTSMNV
CEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHH
VTEQIYNKLFDIKNHSATLTPMLAQSYSISADGKEILLNLRHGVKFHQTPWFTPTRDFNA
HHHHHHHHHHCCCCCCCEECHHHHCCEECCCCCHHHHHHHHCCCEECCCCCCCCCCCCCC
EDVVFSINRVLGGHNTYLPTLAETNVTYSNPQYRVFHEQARKVRFPYFDSIKLNEKIKSV
CHHHEEHHHHHCCCCCCCCCEECCCCEECCCCEEEEHHHHHEECCCCCCCEEHHHHHHHH
TALSPYQVKIELFAPDSSILSHLASQYAIIFSQEYAYQLSADDNLAQLDTHPVGTGPYQV
HCCCCEEEEEEEECCCHHHHHHHHHHEEEEEEECEEEEECCCCCCCCCCCCCCCCCCHHH
KDYVYNQYVRLVRNENYWKKEAKIEHIIVDLSTDRSGRLVKFFNNECQIASYPEVSQIGL
HHHHHHHHHHHHCCCCCHHHHCCEEEEEEEECCCCCCCEEEEECCCCEECCCCCHHHCCC
LKNDDKHYYMQSTDGMNLAYLAFNFDKPLMRDHEIRAAISQSLNRARIIHSIYHNTATVA
EECCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NNIIPEVSWASSVNTPEFEFDYNPKIAKNKLADKNLLLNLWVINEEQVYNPAPFKIAEMI
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCEEEEEEEECHHHCCCCCCHHHHHHH
KWDLAQAGVKVKVRAVTRPFLTAQLRNQSENYDLILSGWLAGNLDPDGFMRPILSCGTKN
HHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCH
ELTNLSNWCNEEFDQFMDRAITTSHLSSRAKAYNEAQELVLRELPIIPIANVKRILVANS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
RVKGVKMTPFGSLDFSTLYFIQEKY
CCCCEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800