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The map label for this gene is fabB

Identifier: 16273433

GI number: 16273433

Start: 1605147

End: 1606367

Strand: Reverse

Name: fabB

Synonym: HI1533

Alternate gene names: 16273433

Gene position: 1606367-1605147 (Counterclockwise)

Preceding gene: 16273441

Following gene: 16273431

Centisome position: 87.77

GC content: 41.44

Gene sequence:

>1221_bases
ATGAGAAGAACTGTAATTACAGGCTTTGGGATTATTTCAAGTATCGGTAACAACAAAGAAGAAGTATTGGCTTCATTAAA
AGCAGGGAAATCAGGTATTGAAGTTGTGCCTGAGTTTGTAGAAATGAATATGCGTAGCCATGTTGCCGGAACAATCAAAT
TAAACCCAAGCGAGCACATTGATCGTAAAGTGTTCCGTTTTATGGGTGATGCAGCGGCTTATGCTTATCTTTCTATGCGT
GAAGCGATTGAGGATGCTGGCTTAACAGAAGATCAAGTTTCTAATGATCGTACTGGTTTAGTGATTGGTGCGGGTACGGG
TTCTGCACATAACCAGTTAGTGGCTTGTGATGCGGTGCGTGGTCCTAGAGGTGTAAAGGCGATTGGTCCTTACGCAGTAA
CGAAAACAATGGCATCAAGTGTTTCTGCCTGTTTAGCTACTCCTTATAAAATCCGTGGTGTGAACTATTCAATGAGTTCT
GCTTGTGCAACCTCTGCACATTGTATCGGTCATGCGGTTGAGTTAATTCAATTAGGCAAACAAGATGTGGTTTTTGCAGG
TGGTGCGGAAGAATTATCTTGGGAATGTGCAACTGAATTTGATGCGATGGGTGCCGTTTCAACTAAATACAATGAAACGC
CAGAAAAAGCATCTCGTGCTTATGACGCAAATCGTGACGGTTTCGTTATTGCAGGTGGTGGTGCTGTTGTGGTTGTGGAA
GAATTAGAACATGCACTTGCTCGTGGTGCAAAAATTTACGCTGAAATTGTAGGTTATGGCGCAACTTCTGATGGTTACGA
TATGGTTGCACCAAGTGGTGAAGGTGCAGAGCGTTGTATGAAACAAGCAATGGCAACTGTCGATACCCCAATTGATTACA
TTAATGTACATGGCACATCTACACCAGTAGGTGACGTGAAAGAATTAGGTGCAATCAAAAATGTATTTGGTGACAAAATC
CCAGCGATTTCTTCAACTAAATCAATGACTGGTCACTCTTTAGGTGCGGCGGGTGCACACGAAGCAATTTACACGTTATT
AATGTTGGATAATGATTTTATTGCACCAAGTATTAATATCGAAACCTTAGATGAAGCCGCTGAAGGTTGCAACATCGTTA
CTGAGACGAAAGAAAATGCAGGATTACAAACTGTCATGTCAAACAGCTTTGGTTTTGGTGGTACAAATGCGACATTAATT
TTTAAACGTTATAACGGTTAA

Upstream 100 bases:

>100_bases
TTCTGAACTGGTCGAACAAATGAATTATTGCTTGAAATATTTTTATTTCGTAGTAATTTTGAGTCGTTATTTTTACATAT
AAAACAATAAGGAAGAAGCA

Downstream 100 bases:

>100_bases
AACTCTTCTATGAAAAAAGCCACTTTCGATTGAAAGTGGCTTTTTTGTATAAATTAAAAAGAAAAATTAAGCAACGATAC
CAAATTGTTCTTTCATTAAT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRTVITGFGIISSIGNNKEEVLASLKAGKSGIEVVPEFVEMNMRSHVAGTIKLNPSEHIDRKVFRFMGDAAAYAYLSMR
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLVACDAVRGPRGVKAIGPYAVTKTMASSVSACLATPYKIRGVNYSMSS
ACATSAHCIGHAVELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNETPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKI
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDEAAEGCNIVTETKENAGLQTVMSNSFGFGGTNATLI
FKRYNG

Sequences:

>Translated_406_residues
MRRTVITGFGIISSIGNNKEEVLASLKAGKSGIEVVPEFVEMNMRSHVAGTIKLNPSEHIDRKVFRFMGDAAAYAYLSMR
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLVACDAVRGPRGVKAIGPYAVTKTMASSVSACLATPYKIRGVNYSMSS
ACATSAHCIGHAVELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNETPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKI
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDEAAEGCNIVTETKENAGLQTVMSNSFGFGGTNATLI
FKRYNG
>Mature_406_residues
MRRTVITGFGIISSIGNNKEEVLASLKAGKSGIEVVPEFVEMNMRSHVAGTIKLNPSEHIDRKVFRFMGDAAAYAYLSMR
EAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLVACDAVRGPRGVKAIGPYAVTKTMASSVSACLATPYKIRGVNYSMSS
ACATSAHCIGHAVELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNETPEKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQAMATVDTPIDYINVHGTSTPVGDVKELGAIKNVFGDKI
PAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINIETLDEAAEGCNIVTETKENAGLQTVMSNSFGFGGTNATLI
FKRYNG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=34.375, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=26.7857142857143, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI223972627, Length=136, Percent_Identity=43.3823529411765, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=72.7722772277228, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=39.9515738498789, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=420, Percent_Identity=33.8095238095238, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=39.622641509434, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=371, Percent_Identity=27.2237196765499, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=360, Percent_Identity=25.8333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=32.2869955156951, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=36.7924528301887, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=26.6272189349112, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=26.6272189349112, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581345, Length=369, Percent_Identity=24.1192411924119, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FABB_HAEIN (P43710)

Other databases:

- EMBL:   L42023
- PIR:   A64128
- RefSeq:   NP_439682.1
- ProteinModelPortal:   P43710
- SMR:   P43710
- GeneID:   950395
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1533
- NMPDR:   fig|71421.1.peg.1460
- TIGR:   HI_1533
- HOGENOM:   HBG757733
- OMA:   GDPPEIE
- ProtClustDB:   PRK07967
- BioCyc:   HINF71421:HI_1533-MONOMER
- BRENDA:   2.3.1.41
- GO:   GO:0005737
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR11712

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 42650; Mature: 42650

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: ACT_SITE 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTVITGFGIISSIGNNKEEVLASLKAGKSGIEVVPEFVEMNMRSHVAGTIKLNPSEHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHCEEEEEEECCHHHH
DRKVFRFMGDAAAYAYLSMREAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLVACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEECCC
GPRGVKAIGPYAVTKTMASSVSACLATPYKIRGVNYSMSSACATSAHCIGHAVELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
QDVVFAGGAEELSWECATEFDAMGAVSTKYNETPEKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQAMATVDTPIDYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
TPVGDVKELGAIKNVFGDKIPAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCH
ETLDEAAEGCNIVTETKENAGLQTVMSNSFGFGGTNATLIFKRYNG
HHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRTVITGFGIISSIGNNKEEVLASLKAGKSGIEVVPEFVEMNMRSHVAGTIKLNPSEHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHCEEEEEEECCHHHH
DRKVFRFMGDAAAYAYLSMREAIEDAGLTEDQVSNDRTGLVIGAGTGSAHNQLVACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEECCC
GPRGVKAIGPYAVTKTMASSVSACLATPYKIRGVNYSMSSACATSAHCIGHAVELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
QDVVFAGGAEELSWECATEFDAMGAVSTKYNETPEKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQAMATVDTPIDYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
TPVGDVKELGAIKNVFGDKIPAISSTKSMTGHSLGAAGAHEAIYTLLMLDNDFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCH
ETLDEAAEGCNIVTETKENAGLQTVMSNSFGFGGTNATLIFKRYNG
HHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800