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The map label for this gene is cusC [C]

Identifier: 16273365

GI number: 16273365

Start: 1544081

End: 1545445

Strand: Direct

Name: cusC [C]

Synonym: HI1462

Alternate gene names: 16273365

Gene position: 1544081-1545445 (Clockwise)

Preceding gene: 16273357

Following gene: 16273371

Centisome position: 84.37

GC content: 38.9

Gene sequence:

>1365_bases
ATGTTTAAAATGAAAAATATCACGCTTGCTTTGTTGATGTCTGGTGCATTGGTGGGATGTGCCAATATTGGCGATTCTTA
TCAAGCAAGCCTTGAAGATTACAAGCAATATGAAGAAATTACCAAGCAATATAATGTAAAAGAAAATTGGTGGTCGTTAT
ATGATGATGCGCAATTAAATCGCGTAGTAGGACAAGCATTAATAAACAACAAAGATTTAGCTAAAGCTGCTGTAGCGGTA
AACCGTGCACTTTATAGTGCAAATTTAGTGGGTGCAAATTTAGTGCCTGCATTTAATGGTTCAACTTCATCAGCAGCACA
ACGCCGAGTTGATATCAGTACAAACTCTGCCATTTCACACAAAGGTTCTTTAAATGTGAGCTATACATTAGATCTGTGGC
AACGTTTGGCCAATACCGTTGATGCGGCGGAATGGTCGCACAAAGCAACTGCAGAAGATATGGAATCGGCTCGTTTATCA
TTAATCAATTCTGTAGTAACAACTTATTATCAAATTGCTTATTTAAATGATGCAATTAGCACAACCAACGAAACGATCAA
ATATTACACGGATATTGGCAATATTATGCAAACGCGTTTAGTGCAAGGCGTGGCTGATGCAGCCAGCGTTGATCAAGCAC
AACAAGCCATATTAACGGCACGTAATAACAAATTAAATTTTGAAACCCAACGCAAAACAGCAGAACAAACACTGCGTAAT
CTTCTCAACCTAAAACCAAATGAAGCATTAAATATCACGTTCCCACATATTATGAATGTGAAAACAGCAGGCGTAAACTT
AAACGTGCCTGTGTCTGTAATTGCAAATCGTCCTGATGTAAAAGCAGCACAATTCCGTTTAAGCAGTGCATTCAAAAATG
CCAAAGCAACTCAAAAAAGTTGGTTCCCAGAGGTTAATTTAGGTGCAAGCCTTTCTTCAACAGCAAGCACGGTTGGTACG
GCGTTACATAACCCTGTGGCTGCTGGCACAGTAGGAATTAGCCTACCGTTCTTAAATTGGAACACCGTAAAATGGAACGT
TAAAATTTCTGAAGCTGACTATGAAACAGCTCGTTTAAATTACGAACAACGTATTACCACCGCTCTCAATAATGTGGATA
CCAACTATTTCGCATTTACCCAAGCGCAAAGTACATTAAGTAATTTACAGCAAACCCATAGTTACAATCAGCGTATCACA
CAATATTATCGAAACCGCTATAATGCGGGCGTATCCGAATTGCGCGAATGGTTAGTTGCAGCCAATACGGAAAAATCATC
ACAACTTGCGATTTTGAATGCAAAATATCAAGTGCTGCAAAGTGAAAATGCGGTATATAGCTCAATGGCGGGATATTATT
TGTAA

Upstream 100 bases:

>100_bases
CAAACATTCATTATAAATAAAAGTCACAATATTTATTTTATAAATAAAAAAGTGCGGTTAAAATCATCCGCACTTTTTAG
TTCGTAGAAAGGAAAATTCA

Downstream 100 bases:

>100_bases
AAATCAAATTGGATTAATCTATGAAAAATCCCTGTTAAATTTCTTTAACAGGGATTTTGTTATTTAAATTAAACCTATTA
TTTTGTCGCTTCTTTCACTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFKMKNITLALLMSGALVGCANIGDSYQASLEDYKQYEEITKQYNVKENWWSLYDDAQLNRVVGQALINNKDLAKAAVAV
NRALYSANLVGANLVPAFNGSTSSAAQRRVDISTNSAISHKGSLNVSYTLDLWQRLANTVDAAEWSHKATAEDMESARLS
LINSVVTTYYQIAYLNDAISTTNETIKYYTDIGNIMQTRLVQGVADAASVDQAQQAILTARNNKLNFETQRKTAEQTLRN
LLNLKPNEALNITFPHIMNVKTAGVNLNVPVSVIANRPDVKAAQFRLSSAFKNAKATQKSWFPEVNLGASLSSTASTVGT
ALHNPVAAGTVGISLPFLNWNTVKWNVKISEADYETARLNYEQRITTALNNVDTNYFAFTQAQSTLSNLQQTHSYNQRIT
QYYRNRYNAGVSELREWLVAANTEKSSQLAILNAKYQVLQSENAVYSSMAGYYL

Sequences:

>Translated_454_residues
MFKMKNITLALLMSGALVGCANIGDSYQASLEDYKQYEEITKQYNVKENWWSLYDDAQLNRVVGQALINNKDLAKAAVAV
NRALYSANLVGANLVPAFNGSTSSAAQRRVDISTNSAISHKGSLNVSYTLDLWQRLANTVDAAEWSHKATAEDMESARLS
LINSVVTTYYQIAYLNDAISTTNETIKYYTDIGNIMQTRLVQGVADAASVDQAQQAILTARNNKLNFETQRKTAEQTLRN
LLNLKPNEALNITFPHIMNVKTAGVNLNVPVSVIANRPDVKAAQFRLSSAFKNAKATQKSWFPEVNLGASLSSTASTVGT
ALHNPVAAGTVGISLPFLNWNTVKWNVKISEADYETARLNYEQRITTALNNVDTNYFAFTQAQSTLSNLQQTHSYNQRIT
QYYRNRYNAGVSELREWLVAANTEKSSQLAILNAKYQVLQSENAVYSSMAGYYL
>Mature_454_residues
MFKMKNITLALLMSGALVGCANIGDSYQASLEDYKQYEEITKQYNVKENWWSLYDDAQLNRVVGQALINNKDLAKAAVAV
NRALYSANLVGANLVPAFNGSTSSAAQRRVDISTNSAISHKGSLNVSYTLDLWQRLANTVDAAEWSHKATAEDMESARLS
LINSVVTTYYQIAYLNDAISTTNETIKYYTDIGNIMQTRLVQGVADAASVDQAQQAILTARNNKLNFETQRKTAEQTLRN
LLNLKPNEALNITFPHIMNVKTAGVNLNVPVSVIANRPDVKAAQFRLSSAFKNAKATQKSWFPEVNLGASLSSTASTVGT
ALHNPVAAGTVGISLPFLNWNTVKWNVKISEADYETARLNYEQRITTALNNVDTNYFAFTQAQSTLSNLQQTHSYNQRIT
QYYRNRYNAGVSELREWLVAANTEKSSQLAILNAKYQVLQSENAVYSSMAGYYL

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family

Homologues:

Organism=Escherichia coli, GI1786785, Length=466, Percent_Identity=24.4635193133047, Blast_Score=111, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1462_HAEIN (P45217)

Other databases:

- EMBL:   L42023
- PIR:   I64124
- RefSeq:   NP_439611.1
- ProteinModelPortal:   P45217
- SMR:   P45217
- GeneID:   950787
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1462
- NMPDR:   fig|71421.1.peg.1392
- TIGR:   HI_1462
- HOGENOM:   HBG297074
- OMA:   NSAISHK
- ProtClustDB:   CLSK870147
- BioCyc:   HINF71421:HI_1462-MONOMER
- GO:   GO:0016020
- InterPro:   IPR003423
- InterPro:   IPR010131
- TIGRFAMs:   TIGR01845

Pfam domain/function: PF02321 OEP

EC number: NA

Molecular weight: Translated: 50290; Mature: 50290

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKMKNITLALLMSGALVGCANIGDSYQASLEDYKQYEEITKQYNVKENWWSLYDDAQLN
CCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHH
RVVGQALINNKDLAKAAVAVNRALYSANLVGANLVPAFNGSTSSAAQRRVDISTNSAISH
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHEEECCCCCCCCC
KGSLNVSYTLDLWQRLANTVDAAEWSHKATAEDMESARLSLINSVVTTYYQIAYLNDAIS
CCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTNETIKYYTDIGNIMQTRLVQGVADAASVDQAQQAILTARNNKLNFETQRKTAEQTLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LLNLKPNEALNITFPHIMNVKTAGVNLNVPVSVIANRPDVKAAQFRLSSAFKNAKATQKS
HHCCCCCCEEEEECCHHCCEEECCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
WFPEVNLGASLSSTASTVGTALHNPVAAGTVGISLPFLNWNTVKWNVKISEADYETARLN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCEEEEEEEEEECCCCHHHHCC
YEQRITTALNNVDTNYFAFTQAQSTLSNLQQTHSYNQRITQYYRNRYNAGVSELREWLVA
HHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ANTEKSSQLAILNAKYQVLQSENAVYSSMAGYYL
CCCCCCCEEEEEEHHHHHHHCCCHHHHHHCCCCC
>Mature Secondary Structure
MFKMKNITLALLMSGALVGCANIGDSYQASLEDYKQYEEITKQYNVKENWWSLYDDAQLN
CCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHH
RVVGQALINNKDLAKAAVAVNRALYSANLVGANLVPAFNGSTSSAAQRRVDISTNSAISH
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHEEECCCCCCCCC
KGSLNVSYTLDLWQRLANTVDAAEWSHKATAEDMESARLSLINSVVTTYYQIAYLNDAIS
CCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTNETIKYYTDIGNIMQTRLVQGVADAASVDQAQQAILTARNNKLNFETQRKTAEQTLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LLNLKPNEALNITFPHIMNVKTAGVNLNVPVSVIANRPDVKAAQFRLSSAFKNAKATQKS
HHCCCCCCEEEEECCHHCCEEECCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
WFPEVNLGASLSSTASTVGTALHNPVAAGTVGISLPFLNWNTVKWNVKISEADYETARLN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCEEEEEEEEEECCCCHHHHCC
YEQRITTALNNVDTNYFAFTQAQSTLSNLQQTHSYNQRITQYYRNRYNAGVSELREWLVA
HHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ANTEKSSQLAILNAKYQVLQSENAVYSSMAGYYL
CCCCCCCEEEEEEHHHHHHHCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800