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The map label for this gene is msrA

Identifier: 16273361

GI number: 16273361

Start: 1539163

End: 1540224

Strand: Reverse

Name: msrA

Synonym: HI1455

Alternate gene names: 16273361

Gene position: 1540224-1539163 (Counterclockwise)

Preceding gene: 30995450

Following gene: 16273360

Centisome position: 84.16

GC content: 37.57

Gene sequence:

>1062_bases
ATGAAACTATCAAAAACATTTCTATTTATTACCGCACTTTGCTGTGCTACACCAACTTTAGCAATACAAAATTCAACATC
ATCATCTGGAGAACAAAAAATGGCAATGGAAAATACACAAAACATTCGAGAAATTTATCTTGCTGGCGGCTGTTTTTGGG
GTATGGAAGCATATATGGAGCGTATTCACGGCGTGAAAGATGCGATTTCTGGCTATGCAAATGGTAATACGGAGAAAACC
AGTTATCAGATGATTGGGCTAACCGATCACGCAGAAACGGTAAAAGTTACTTACGATGCAAACCAAATTTCGTTAGATAA
ATTGCTTAAATATTATTTTAAAGTGATTGATCCAACCAGCGTAAATAAACAAGGTAACGACCGTGGCAGACAATATCGCA
CAGGGATTTATTATCAAGATGGAGCAGATAAAGCGGTGATCGGACAAGCACTCGCCCAGCTTCAAACCAAATATAAAAAA
CCAGTACAAATTGAGGTGCAACCACTTAAAAATTACATCGTAGCAGAAGAATATCATCAGGATTATTTGAAGAAAAATCC
AAATGGCTACTGCCATATTGATATTACCAAAGCTGATGAACCTGTGATTGACGAGAAAGATTATCCGAAACCGAGTGATG
CAGAACTCAAAGCGAAATTGACACCGTTGCAATATTCCGTTACTCAAAATAAACATACTGAACGCTCTTTCAGTAACGAA
TATTGGGATAACTTCCAACCTGGTATTTATGTTGATATCACTACAGGCGAGCCTGTTTTCTCTTCAAATGATAAATTTGA
ATCAGGTTGTGGCTGGCCAAGTTTTACGAAACCGATCATTAAAGATGTAGTGCATTATGAAACCGATAACAGCTTCAATA
TGCAACGTACCGAAGTGTTAAGTCGTGCGGGCAATGCCCATTTGGGTCACGTTTTTGATGACGGTCCGAAAGATAAAGGT
GGTTTGCGTTATTGCATTAACAGTGCATCAATTAAATTTATTCCGTTAGCAGAAATGGAAAAGGCAGGATATGGATATTT
GATTCAATCCATTAAAAAATAA

Upstream 100 bases:

>100_bases
TCTACCACATTTCAAACTTAAGTAAAAAAATCTGTAAGAAATCGGATTATCCGCCGTCTAACCTTATGTAACGTTAATTT
TCACATCATAAGGAAAAACA

Downstream 100 bases:

>100_bases
GGAGATGTAGGATGTTAGATCAACAACTCCTTATTGGAACTGTATTTTTAGCGGGGCTTGCTTCTTTTCTTTCGCCTTGT
ATTTTCCCGATTATTCCAAT

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKLSKTFLFITALCCATPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTEKT
SYQMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIGQALAQLQTKYKK
PVQIEVQPLKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDITTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK

Sequences:

>Translated_353_residues
MKLSKTFLFITALCCATPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTEKT
SYQMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIGQALAQLQTKYKK
PVQIEVQPLKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDITTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
>Mature_353_residues
MKLSKTFLFITALCCATPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTEKT
SYQMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIGQALAQLQTKYKK
PVQIEVQPLKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDITTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=49.1935483870968, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=49.1935483870968, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=49.1935483870968, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=49.1935483870968, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912516, Length=165, Percent_Identity=36.969696969697, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=36.1963190184049, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI117606353, Length=131, Percent_Identity=42.7480916030534, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI208609993, Length=163, Percent_Identity=34.9693251533742, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=45.9677419354839, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790665, Length=161, Percent_Identity=36.0248447204969, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=130, Percent_Identity=40, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=130, Percent_Identity=40, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=40.1273885350318, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=34.6153846153846, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221378664, Length=129, Percent_Identity=47.2868217054264, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45553335, Length=121, Percent_Identity=47.9338842975207, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356369, Length=121, Percent_Identity=47.9338842975207, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=136, Percent_Identity=44.8529411764706, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24645799, Length=121, Percent_Identity=47.9338842975207, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24645804, Length=132, Percent_Identity=43.9393939393939, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24645801, Length=132, Percent_Identity=43.9393939393939, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRAB_HAEIN (P45213)

Other databases:

- EMBL:   L42023
- PIR:   E64124
- RefSeq:   NP_439606.1
- ProteinModelPortal:   P45213
- GeneID:   950358
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1455
- NMPDR:   fig|71421.1.peg.1388
- TIGR:   HI_1455
- HOGENOM:   HBG715255
- OMA:   GIYYTDK
- ProtClustDB:   CLSK808528
- BioCyc:   HINF71421:HI_1455-MONOMER
- BRENDA:   1.8.4.11
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- HAMAP:   MF_01401
- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00401
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01625 PMSR; PF01641 SelR; SSF55068 MsrA; SSF51316 Mss4_like

EC number: =1.8.4.11; =1.8.4.12

Molecular weight: Translated: 39864; Mature: 39864

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: ACT_SITE 51-51 ACT_SITE 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSKTFLFITALCCATPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYME
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
RIHGVKDAISGYANGNTEKTSYQMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTS
HHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEECHHHHHHHHHHHCCCCC
VNKQGNDRGRQYRTGIYYQDGADKAVIGQALAQLQTKYKKPVQIEVQPLKNYIVAEEYHQ
CCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
DYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHCHH
YWDNFQPGIYVDITTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVL
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SRAGNAHLGHVFDDGPKDKGGLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MKLSKTFLFITALCCATPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYME
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
RIHGVKDAISGYANGNTEKTSYQMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTS
HHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEECHHHHHHHHHHHCCCCC
VNKQGNDRGRQYRTGIYYQDGADKAVIGQALAQLQTKYKKPVQIEVQPLKNYIVAEEYHQ
CCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
DYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHCHH
YWDNFQPGIYVDITTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVL
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SRAGNAHLGHVFDDGPKDKGGLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023