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The map label for this gene is trpC

Identifier: 16273300

GI number: 16273300

Start: 1486204

End: 1487637

Strand: Direct

Name: trpC

Synonym: HI1389.1

Alternate gene names: 16273300

Gene position: 1486204-1487637 (Clockwise)

Preceding gene: 16273299

Following gene: 16273307

Centisome position: 81.21

GC content: 38.91

Gene sequence:

>1434_bases
ATGATGATCACTCAAGATTTTACCAAACCCATTGATTCCGCTACGGTGCTACAAAAAATCGTGCTTGATAAAGCACAATG
GGTTAAAGCAAAAGAAAAGGAATTTCCCCTTTCACAATTTAAACAAAACATTCAAAACTCTGACCGCTCTTTTTATGATG
CGTTAGCAAAAGGTACGCATCAAAAGCCCGCTTACATTTTGGAATGTAAAAAAGCCTCCCCTTCTAAGGGATTAATTCGT
GCTGAATTTAATTTGGAAGAAATCGCCAATGTCTATAAACATTATGCGTCCGCTGTATCTGTTCTGACAGATGAAAAATA
CTTTCAAGGGAATTTTGAATTCTTGCCTTTAGTTCGCGATATCGTAAGCCAACCTGTGCTTTGCAAAGATTTTATGATTA
GCGAATATCAAGTTTACCTTGCTCGCTACTATCAAGTGGATGCAATTTTATTAATGCTTTCTGTGGTAAATGATGAGACT
TATCGTGTGCTGGCAGATCTTGCTCATTCTCTTGGTATGGGCGTATTGACAGAAACCAGTAATGAAGAAGAATTTGAACG
TGCCCTTGCACTTGGTGCGAAAATTATTGGTGTCAATAATCGTAACTTGCACGATTTAACAGTAGATTTAAATCGTGTTG
TTGAACTCACTAAAAAATACGCCGACTGTATTCCTGCTGATGTACGTATTATTAGCGAATCAGGCATTTACAATCACAAG
CAAATTCATCAATTACAAAAGGTGGCGCATGGTTTCTTAATTGGGAGTAGCTTAATGGGCAACCAAGATTTGAATAATGC
GGTTCGCTCAGTGATTTTTGGAGAAAATAAAGTATGCGGTTTAACGCGCGCGCAAGATGTCAAAATCGTTTACGAAAACG
GGGCACTTTACGGCGGATTAATCTTCGCAGAACATTCAAAACGCAGTGTGAGTTTACGCCAAGCGCAAGAATTAGTAACC
GCTGCGCCACTTCGATTTGTTGGTGTTTTTCAGAATCAAGAAATTGACTTTATCGTCAAAATAGCCAGCCAGTTGCAGCT
TTATGCGGTGCAATTACATGGTGCAGAAACTGAAGCATTTATTACTGCACTTCGCCAGCAACTACCAAAAAACACGCAAA
TCTGGAAAGCGATTTCGGTCAATACTGAAGCCCAAAGTGCGGTCGATTTTACAGATGATTTGAATGTGGATCGTTATATT
TTTGATAGCCAAACAGCGAACCAACAAGGTGGCACGGGTAAAACCTTTGATTGGTCATTAATTCCTGAAAATCTTAAACA
CAAGATTATTTTAGCTGGAGGTATCTCACCAAATAATGTGGAACAAGCCATTGCGCAAGGTTGCTTAGGTTTAGATCTTA
ATTCTGGGGTGGAAAGTTCTGCGGGCGTCAAAGATCAAGAAAAAGTGCGGTTAGTTTTTAATAATATTTATTAA

Upstream 100 bases:

>100_bases
TGTACTGGCGCATCTTGTATCAGGTAAAGCCTTTGAAACATTACAGAAATTAACCACATATTAATAAAAGCTAATTTTAT
ACGCCACAATAAGAAGAAAA

Downstream 100 bases:

>100_bases
TTTTAATAACATAGAAATCACTAAATTTCAGCTTAAATACTAATAGGAGTAAAAATATTATGTGTTTAGGCGTTCCGATC
AAATTGTCAAAATTGATGAA

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MMITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIR
AEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRDIVSQPVLCKDFMISEYQVYLARYYQVDAILLMLSVVNDET
YRVLADLAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTKKYADCIPADVRIISESGIYNHK
QIHQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRSVSLRQAQELVT
AAPLRFVGVFQNQEIDFIVKIASQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDDLNVDRYI
FDSQTANQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIAQGCLGLDLNSGVESSAGVKDQEKVRLVFNNIY

Sequences:

>Translated_477_residues
MMITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIR
AEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRDIVSQPVLCKDFMISEYQVYLARYYQVDAILLMLSVVNDET
YRVLADLAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTKKYADCIPADVRIISESGIYNHK
QIHQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRSVSLRQAQELVT
AAPLRFVGVFQNQEIDFIVKIASQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDDLNVDRYI
FDSQTANQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIAQGCLGLDLNSGVESSAGVKDQEKVRLVFNNIY
>Mature_477_residues
MMITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTHQKPAYILECKKASPSKGLIR
AEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRDIVSQPVLCKDFMISEYQVYLARYYQVDAILLMLSVVNDET
YRVLADLAHSLGMGVLTETSNEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTKKYADCIPADVRIISESGIYNHK
QIHQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGLIFAEHSKRSVSLRQAQELVT
AAPLRFVGVFQNQEIDFIVKIASQLQLYAVQLHGAETEAFITALRQQLPKNTQIWKAISVNTEAQSAVDFTDDLNVDRYI
FDSQTANQQGGTGKTFDWSLIPENLKHKIILAGGISPNNVEQAIAQGCLGLDLNSGVESSAGVKDQEKVRLVFNNIY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=462, Percent_Identity=55.1948051948052, Blast_Score=505, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6322638, Length=226, Percent_Identity=37.1681415929204, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_HAEIN (P46451)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_439543.1
- ProteinModelPortal:   P46451
- SMR:   P46451
- GeneID:   950301
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1389.1
- NMPDR:   fig|71421.1.peg.1327
- TIGR:   HI_1389.1
- HOGENOM:   HBG296890
- OMA:   YILECKK
- ProtClustDB:   PRK09427
- BioCyc:   HINF71421:HI_1389.1-MONOMER
- BRENDA:   4.1.1.48
- BRENDA:   5.3.1.24
- HAMAP:   MF_00134_B
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48; =5.3.1.24

Molecular weight: Translated: 53306; Mature: 53306

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCC
QKPAYILECKKASPSKGLIRAEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRD
CCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
IVSQPVLCKDFMISEYQVYLARYYQVDAILLMLSVVNDETYRVLADLAHSLGMGVLTETS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCC
NEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTKKYADCIPADVRIISESGIYNHK
CHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
QIHQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGL
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCEEEEE
IFAEHSKRSVSLRQAQELVTAAPLRFVGVFQNQEIDFIVKIASQLQLYAVQLHGAETEAF
EEEECCCCHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHEEEEEEECCCCHHHH
ITALRQQLPKNTQIWKAISVNTEAQSAVDFTDDLNVDRYIFDSQTANQQGGTGKTFDWSL
HHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEE
IPENLKHKIILAGGISPNNVEQAIAQGCLGLDLNSGVESSAGVKDQEKVRLVFNNIY
CCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEECCC
>Mature Secondary Structure
MMITQDFTKPIDSATVLQKIVLDKAQWVKAKEKEFPLSQFKQNIQNSDRSFYDALAKGTH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCC
QKPAYILECKKASPSKGLIRAEFNLEEIANVYKHYASAVSVLTDEKYFQGNFEFLPLVRD
CCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
IVSQPVLCKDFMISEYQVYLARYYQVDAILLMLSVVNDETYRVLADLAHSLGMGVLTETS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCC
NEEEFERALALGAKIIGVNNRNLHDLTVDLNRVVELTKKYADCIPADVRIISESGIYNHK
CHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
QIHQLQKVAHGFLIGSSLMGNQDLNNAVRSVIFGENKVCGLTRAQDVKIVYENGALYGGL
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCEEEEE
IFAEHSKRSVSLRQAQELVTAAPLRFVGVFQNQEIDFIVKIASQLQLYAVQLHGAETEAF
EEEECCCCHHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHEEEEEEECCCCHHHH
ITALRQQLPKNTQIWKAISVNTEAQSAVDFTDDLNVDRYIFDSQTANQQGGTGKTFDWSL
HHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEE
IPENLKHKIILAGGISPNNVEQAIAQGCLGLDLNSGVESSAGVKDQEKVRLVFNNIY
CCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800