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The map label for this gene is maeB

Identifier: 16273164

GI number: 16273164

Start: 1318036

End: 1320306

Strand: Direct

Name: maeB

Synonym: HI1245

Alternate gene names: 16273164

Gene position: 1318036-1320306 (Clockwise)

Preceding gene: 16273160

Following gene: 16273165

Centisome position: 72.02

GC content: 41.39

Gene sequence:

>2271_bases
ATGACCGAACAATTACGTCAAGCAGCCTTAGATTTCCACGAATTTCCAATTCCTGGAAAAATCGAAGTTACCCCAACAAA
ATCATTAGCAACCCAACGTGATCTTGCCTTAGCTTATTCACCGGGTGTGGCAGAGCCTTGTTTAGAAATTGAAAAAGATC
CTGCAGCCTCTTACAAATATACAGCACGTGGCAATTTAGTGGCGGTGATTTCCAATGGTACAGCGGTGCTTGGGCTTGGC
AATATTGGCGCGCTTGCCGGCAAACCTGTAATGGAAGGAAAGGGCGTGTTGTTCAAAAAATTCGCAGGCATCAACGTGTT
TGATATTGAAGTGAATGAACATGATCCCGATAAACTTGTAGATATTATTGCCTCGTTAGAGCCAACTTTCGGTGGGGTAA
ATCTTGAAGATATTAAAGCACCGGAATGTTTCTATATTGAACAAAAATTGCGTGAGAGAATGAATATTCCTGTATTCCAT
GATGACCAACATGGCACGGCGATCATCAGCGCTGCCGCGATCATCAATTCTCTTCGTATTGTAGGTAAAAAAATTGAAGA
TGTACGCTTAGTGGCTTCTGGTGCGGGTGCTGCATCTATTGCGTGTTTGAACTTATTGCTTTCTTTAGGTATGAAACGTG
AAAACATCACGGTTTGTGACTCGAAAGGCGTGGTATATAAAGGCCGTGATGACAAAATGGATCAAACCAAAAAAGAGTAT
GCAATTGAAGATAATGGCTGGCGTAAACTTGCTGATGCGATTCCAAATGCAGATATTTTCTTAGGTTGTTCTGCGGCTGG
TGCGCTTACACAAGATATGGTTAAAAGTATGGCTGCGCATCCAATTATTCTTGCTTTGGCTAATCCAAATCCTGAAATTA
CCCCGCCAGAAGCAAAAGCAGTTCGTCCTGATGCGATTGTATGTACAGGCCGCTCTGATTATCCAAACCAAGTAAATAAC
GTGCTTTGTTTCCCATTTATTTTCCGTGGTGCATTAGATGTGGGCGCAACCACTATTAATGAAGAAATGAAACGTGCGGC
AGTTTATGCTATCGCAGACCTTGCATTAGAAGAGCAAAACGAAGTGGTAACCTCTGCTTACGGTGGCGAAGGGGCAACAT
TTGGTGCGGATTATGTGATTCCTCGTCCATTTGATCCTCGCTTGATTGTGCGTATTGCACCAGCGGTAGCAAAAGCTGCA
ATGGAATCTGGTGTGGCAACTCGTCCAATTCAAAATTGGGATGCTTATGTTGAAAAACTCACTCAGTTTGTTTACAAAAC
GAGCTTGTTTATGCGTCCTATTTTCAGCCAAGCAAAATCGGCAAAACAACGCATTATTTTAGCGGAAGGGGAAGAAAATA
AAGCATTACATGCCACCCAAGAAGTGATTTCAATGGGCTTGGCAAATCCAATTTTAATTGGTCGCCGCAGCGTGATTGAA
GAAAAAATTAAAAAACTTGGTTTACGTTTAACTGCAGGTGTAGATTTTGAAATTGTGGATAACGAAGATAATCCTCGCTA
TGAAGAATGTTGGAAACACTATTACGAACTTACTAAACGTAAAGGCATTACACCTGCAATCGCAAAACGTGTCGTGCGTT
CTAACACCACCGTATTAGCTTCTACATTGCTTAGCTTAGGTTATGCAGACGCTTTAGTATGTGGCTTATTTGGTTCATAC
GGAAAACACCTTGCCTCTATTCGAGATATTATTGGCTTAAAAGACGGTGTGAAAACTGCCGCTGCTTTAAATAGTCTTGT
ATTACCGACGGGTAACGTATTCTTAACAGATACTCACGTAAACAGTAATCCTACAGCAGAAGAATTAGCTGAAATTACCT
TAATGGCAGCAGAAGAAATTCATCGTTTTGGTATTGAACCTGCAGTTGCATTGCTTTCTCATTCTAATTTTGGTTCATCT
GATTCATTAGGCGCACCAAAAATGCGCGAAGTATTACAGATCGTCAAAGAGCGCAATCCACATTTAATGATTGATGGGGA
AATGCGTGGCGATTTAGCGATGAATGAAGCACACAGAAAAGAATTAATGCCTGATAGCCCATTGAAAGGAAGCGCAAATT
TATTAGTGTTCCCTGATTTGAGTGCATCACGTATTAGTTATAGCTTATTACGCGGCACTACTACGGCAATTACCGTTGGC
CCGATCTTAATGGGAATGAATAAATCTGCGCATATTCTTAATCCAGGTGCATCTGTTCGTCGTATTATCAATATGATTGC
CTATGCAGCAGTGAAAGCACAACAAGAGTAA

Upstream 100 bases:

>100_bases
AAGTTGTAAAAGTTTGCAGTTCGTCACAATTTTTTGAATAAAAAACAGATATAATCGACGCAATATTTCAATCCTGTTTC
AAGAAAATGGAGCACTTATT

Downstream 100 bases:

>100_bases
TTAAAAAAGTGCGGTGAATTTCTGTCGTTTATTTAATGAAGCCTCGATTTTTCTCGAGGCTTTATTTTCTAGTGAATGTG
TTTACATTTGAGATTAAGTA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MTEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKEY
AIEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAA
MESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSY
GKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSS
DSLGAPKMREVLQIVKERNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE

Sequences:

>Translated_756_residues
MTEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFH
DDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKEY
AIEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAA
MESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSY
GKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSS
DSLGAPKMREVLQIVKERNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
>Mature_755_residues
TEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLGN
IGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLVDIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHD
DQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKEYA
IEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKAVRPDAIVCTGRSDYPNQVNNV
LCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAAM
ESGVATRPIQNWDAYVEKLTQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIEE
KIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLASTLLSLGYADALVCGLFGSYG
KHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHVNSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSD
SLGAPKMREVLQIVKERNPHLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVGP
ILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family

Homologues:

Organism=Homo sapiens, GI4505143, Length=405, Percent_Identity=26.1728395061728, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62420882, Length=335, Percent_Identity=25.9701492537313, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI62420880, Length=335, Percent_Identity=25.9701492537313, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI239049447, Length=335, Percent_Identity=25.9701492537313, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4505145, Length=320, Percent_Identity=25.9375, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI270265879, Length=320, Percent_Identity=25.9375, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=757, Percent_Identity=68.6922060766182, Blast_Score=1110, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=31.5028901734104, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788800, Length=324, Percent_Identity=31.7901234567901, Blast_Score=136, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17537199, Length=452, Percent_Identity=23.8938053097345, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=232, Percent_Identity=31.8965517241379, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646388, Length=348, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281362674, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356279, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362672, Length=396, Percent_Identity=26.7676767676768, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707242, Length=420, Percent_Identity=24.5238095238095, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707238, Length=420, Percent_Identity=24.5238095238095, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=24.6418338108883, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO2_HAEIN (P43837)

Other databases:

- EMBL:   L42023
- PIR:   F64112
- RefSeq:   NP_439401.1
- ProteinModelPortal:   P43837
- SMR:   P43837
- GeneID:   949562
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1245
- NMPDR:   fig|71421.1.peg.1191
- TIGR:   HI_1245
- HOGENOM:   HBG289132
- OMA:   IELAEND
- ProtClustDB:   PRK07232
- BioCyc:   HINF71421:HI_1245-MONOMER
- BRENDA:   1.1.1.40
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF036684
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB

EC number: =1.1.1.40

Molecular weight: Translated: 81881; Mature: 81750

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 94-94 BINDING 162-162 BINDING 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKY
CCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLV
EECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKEY
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCHHHHHHHH
AIEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKA
CCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQN
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
EVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAAMESGVATRPIQNWDAYVEKL
CEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCEECCHHHHHH
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLA
HHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
STLLSLGYADALVCGLFGSYGKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEEECC
NSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSDSLGAPKMREVLQIVKERNP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
HLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEC
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEQLRQAALDFHEFPIPGKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKY
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCHHHHCCCCCCCCEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINVFDIEVNEHDPDKLV
EECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEECCCCHHHHH
DIIASLEPTFGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VGKKIEDVRLVASGAGAASIACLNLLLSLGMKRENITVCDSKGVVYKGRDDKMDQTKKEY
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCHHHHHHHH
AIEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSMAAHPIILALANPNPEITPPEAKA
CCCCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQN
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
EVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAPAVAKAAMESGVATRPIQNWDAYVEKL
CEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHH
TQFVYKTSLFMRPIFSQAKSAKQRIILAEGEENKALHATQEVISMGLANPILIGRRSVIE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCEECCHHHHHH
EKIKKLGLRLTAGVDFEIVDNEDNPRYEECWKHYYELTKRKGITPAIAKRVVRSNTTVLA
HHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
STLLSLGYADALVCGLFGSYGKHLASIRDIIGLKDGVKTAAALNSLVLPTGNVFLTDTHV
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCEEEEEECC
NSNPTAEELAEITLMAAEEIHRFGIEPAVALLSHSNFGSSDSLGAPKMREVLQIVKERNP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
HLMIDGEMRGDLAMNEAHRKELMPDSPLKGSANLLVFPDLSASRISYSLLRGTTTAITVG
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEC
PILMGMNKSAHILNPGASVRRIINMIAYAAVKAQQE
HHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800