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The map label for this gene is ftsI

Identifier: 16273058

GI number: 16273058

Start: 1197840

End: 1199672

Strand: Direct

Name: ftsI

Synonym: HI1132

Alternate gene names: 16273058

Gene position: 1197840-1199672 (Clockwise)

Preceding gene: 16273057

Following gene: 16273059

Centisome position: 65.45

GC content: 39.17

Gene sequence:

>1833_bases
ATGGTGAAATTTAATTCCTCGCGTAAATCAGGTAAGTCAAAAAAAACAATTAGAAAATTGACCGCACCTGAAACTGTAAA
GCAAAACAAGCCTCAAAAGGTGTTTGAAAAATGCTTTATGCGTGGACGTTATATGCTTTCTACGGTTCTTATTTTACTTG
GCCTGTGTGCTTTAGTCGCACGAGCAGCTTATGTTCAATCTATTAATGCCGATACGTTATCGAATGAAGCGGATAAGCGT
TCTTTGCGTAAAGATGAAGTATTATCGGTGCGTGGTTCTATTTTAGATCGTAATGGTCAGCTTTTATCTGTAAGCGTGCC
GATGAGCGCGATTGTGGCAGATCCAAAAACGATGTTGAAGGAAAATTCGCTTGCGGATAAAGAACGAATTGCAGCTTTAG
CCGAAGAATTAGGTATGACTGAAAATGATTTAGTGAAAAAAATTGAGAAAAATTCTAAATCTGGTTATTTGTATTTAGCA
CGTCAAGTTGAATTAAGTAAAGCTAACTATATTCGTAGATTAAAAATTAAGGGTATTATTTTAGAAACAGAGCATCGCCG
TTTTTATCCTCGTGTAGAAGAAGCTGCACACGTGGTGGGTTATACGGATATTGATGGAAATGGTATTGAAGGCATTGAGA
AAAGTTTTAATTCCCTGCTTGTTGGTAAAGACGGTTCACGTACTGTTCGTAAAGATAAACGTGGGAATATTGTTGCACAT
ATCTCCGATGAGAAAAAATATGATGCACAAGATGTTACCTTAAGTATCGATGAAAAATTGCAATCTATGGTGTATCGTGA
GATTAAAAAGGCGGTGTCTGAGAATAATGCTGAGTCTGGTACTGCGGTGTTAGTTGATGTTCGAACAGGGGAAGTGTTAG
CTATGGCGACTGCGCCCTCTTATAATCCAAACAACCGTGTCGGCGTGAAATCAGAGTTAATGCGTAACCGTGCAATTACC
GATACTTTTGAGCCAGGTTCTACGGTAAAACCTTTCGTTGTTTTAACCGCACTTCAACGAGGTGTAGTTAAACGAGATGA
AATTATTGATACTACGTCCTTTAAATTAAGCGGTAAAGAAATTGTGGACGTTGCACCACGTGCTCAGCAAACTTTAGACG
AGATTTTAATGAACTCTAGTAACCGTGGTGTAAGTCGTCTTGCATTACGTATGCCACCTAGTGCATTAATGGAAACTTAT
CAAAATGCAGGTTTAAGTAAACCGACAGATTTAGGCTTGATCGGAGAGCAAGTTGGGATTTTGAATGCAAATCGTAAACG
CTGGGCAGATATTGAGCGTGCAACAGTCGCTTATGGTTATGGTATTACTGCGACACCTTTACAAATTGCTCGTGCCTATG
CAACCCTTGGTAGTTTCGGTGTTTATCGTCCGCTTTCTATCACTAAAGTTGATCCGCCAGTTATTGGGAAACGGGTTTTC
TCTGAAAAAATAACTAAAGATATTGTGGGAATTTTAGAGAAAGTAGCAATTAAAAATAAACGCGCAATGGTGGAAGGCTA
CCGTGTCGGCGTAAAAACAGGTACGGCACGTAAGATTGAAAATGGACATTATGTAAATAAGTATGTGGCATTTACTGCGG
GTATTGCACCAATTAGTGATCCTCGTTATGCATTAGTGGTTTTGATCAATGATCCAAAAGCAGGAGAATATTATGGTGGT
GCGGTTTCTGCCCCTGTATTCTCTAACATTATGGGCTATGCGTTACGTGCAAATGCTATTCCGCAAGATGCTGAAGCAGC
TGAAAACACAACAACGAAAAGTGCAAAACGTATTGTTTATATTGGCGAACACAAGAATCAAAAAGTGAATTAA

Upstream 100 bases:

>100_bases
GGATAGCACGCGAGTAGAATCTATTGCGATTAGTACATTAAAAATGAAAGTTGTTTCTTCAGAGCAAGAAGTTGAAATTA
GAGAATAATAGGTAAAAAAA

Downstream 100 bases:

>100_bases
GGAAAAATTATGAAAAAACTCACCGCACTTTTTAATTTGCCTGAATTAAAGAATGATATAGAACTCCATAATATGGTGTT
AGATAGCCGTAAGGTTAAAG

Product: penicillin-binding protein 3

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKR
SLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLA
RQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAH
ISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAIT
DTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETY
QNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVF
SEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGG
AVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN

Sequences:

>Translated_610_residues
MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKR
SLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLA
RQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAH
ISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAIT
DTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETY
QNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVF
SEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGG
AVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN
>Mature_610_residues
MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKR
SLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLA
RQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAH
ISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAIT
DTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETY
QNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVF
SEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGG
AVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family

Homologues:

Organism=Escherichia coli, GI1786272, Length=563, Percent_Identity=53.1083481349911, Blast_Score=597, Evalue=1e-171,
Organism=Escherichia coli, GI1786854, Length=596, Percent_Identity=23.3221476510067, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTSI_HAEIN (P45059)

Other databases:

- EMBL:   L42023
- PIR:   G64184
- RefSeq:   NP_439290.1
- ProteinModelPortal:   P45059
- GeneID:   950626
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1132
- NMPDR:   fig|71421.1.peg.1085
- TIGR:   HI_1132
- HOGENOM:   HBG712588
- OMA:   DIERATM
- ProtClustDB:   CLSK869980
- BioCyc:   HINF71421:HI_1132-MONOMER
- BRENDA:   2.4.1.129
- DrugBank:   DB00303
- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase; SSF56519 PBP_dimer; SSF56601 PBP_transp_fold

EC number: =2.4.1.129

Molecular weight: Translated: 67167; Mature: 67167

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: ACT_SITE 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVA
CCCCCCCCCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLK
HHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCHHHHHH
ENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGII
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHEEEEEEEEEE
LETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAH
EECCCCCCCCCHHHHHHEEEEECCCCCCCHHHHHHHHCEEECCCCCCHHHHCCCCCEEEE
ISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPS
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCC
YNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKE
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEECCCH
IVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGI
HHHCCCHHHHHHHHHHHCCCCCCHHHEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHCE
LNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVF
ECCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHH
SEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISD
HHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEECCCCCCCCCCCEEHHEEEEECCCCCCCC
PRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVY
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEE
IGEHKNQKVN
EECCCCCCCC
>Mature Secondary Structure
MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVA
CCCCCCCCCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLK
HHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCHHHHHH
ENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGII
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHEEEEEEEEEE
LETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAH
EECCCCCCCCCHHHHHHEEEEECCCCCCCHHHHHHHHCEEECCCCCCHHHHCCCCCEEEE
ISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPS
ECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCC
YNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKE
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEECCCH
IVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGI
HHHCCCHHHHHHHHHHHCCCCCCHHHEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHCE
LNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVF
ECCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHH
SEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISD
HHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEECCCCCCCCCCCEEHHEEEEECCCCCCCC
PRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVY
CCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEE
IGEHKNQKVN
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800