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The map label for this gene is lpxB [H]

Identifier: 16272991

GI number: 16272991

Start: 1124850

End: 1126022

Strand: Reverse

Name: lpxB [H]

Synonym: HI1060

Alternate gene names: 16272991

Gene position: 1126022-1124850 (Counterclockwise)

Preceding gene: 16272992

Following gene: 16272990

Centisome position: 61.53

GC content: 40.07

Gene sequence:

>1173_bases
ATGAACAAAACAAATCCAACCATTGCTCTTGTTGCAGGAGAAGTGTCTGGCGATATTCTCGGGGCGGGATTAATACGCCA
GCTCAAAGCACATTATCCTAATGCGCGCTTTATTGGCATTGCAGGCCCAAGAATGTTGGCTGAAGGTTGTGAGACGCTTG
TTGATATGGAAGAGCTTTCAGTCATGGGCTTGGCTGAAATATTAAAACATCTTCCTCGTCTGTTGAAAATTCGCAAAAAT
GTCATTCAAACTATGTTGCAAGAAAAACCTGATGTTTACATCGGCATTGATGCGCCTGATTTTAATTTGGATGTAGAACT
TAAACTAAAAGCGAACGGAATTAAAACTATTCATTACGTGAGCCCCTCTGTATGGGCTTGGCGTCAAAACCGCATCCATA
AAATTGCCAAAGCAACTCATCAAGTTCTAGCCTTTTTGCCTTTTGAGAAAGCCTTTTACGATAAATTTAATGTGCCTTGC
CGTTTTATTGGGCACACAATGGCAGATGCTATTCCGCTCAAACCAAACCGTGCCGAAGCCTGCCAAACGTTACAGATTGA
TCCCGCACAACGCTATTTAGCAATCTTAGTTGGAAGCCGAGGTTCAGAAGTGGAATTTCTGGCTGAGCCTTTCTTAAAAA
CCGCTTTATTATTAAAAGAACAATTCCCAGATTTACAATTCCTCGTGCCTTTAGTGAACGAAAAACGACGAATTCAATTT
GAAACCATTAAAGCTAAAATTACGCCAAATCTAGACCTGCATTTAATTGATGGCAATGCACGACAAGCAATGATCGCAGC
TGATGCAACACTTCTTGCTTCAGGAACAGCAGCACTTGAAGCAATGCTTTGTAAATCCCCCATGGTAGTTGGCTATCGAA
TGAAACCACTGACCTATTTCTTAGCAAAACGTTTAGTGAAAACTGATTATATTTCTTTACCAAACTTGCTTGCGAATGAA
ATGCTTGTTCCTGAAATGATTCAAGAAGAATGCACGCCAGAATTGCTTGCTGAAAAACTATCAGTTTATCTTTCTGATGA
TGAAAGTGCGGTAAAAAATCGCCATGTTTTAATTCAGCACTTCACGGATTTACACCAAAAAATTCAATGCAATGCCGATA
AGCAAGCGGCTCAAGCGGTCATTGATTTATTAGAAGGAAAAGAAAATGTTTGA

Upstream 100 bases:

>100_bases
TTTCAAACGTTCAACTCGCGGGATTATTCGTTAATAAAACTTCTTCATTTTCAACCGCACTTTACACACCAAAGTGCGGT
TATTTTTTAGGATAAATTTG

Downstream 100 bases:

>100_bases
ATATCCACAAGGCTATAAATTGATCGCTGGCGTTGATGAAGTTGGGCGAGGCCCTCTAGTTGGGGCGGTTGTCACGGCAG
CCGTGATTTTAGATCCTCAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
ETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV

Sequences:

>Translated_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
ETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV
>Mature_390_residues
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELSVMGLAEILKHLPRLLKIRKN
VIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYVSPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPC
RFIGHTMADAIPLKPNRAEACQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
ETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYFLAKRLVKTDYISLPNLLANE
MLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQHFTDLHQKIQCNADKQAAQAVIDLLEGKENV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=384, Percent_Identity=63.28125, Blast_Score=490, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43638; Mature: 43638

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
HHEEECCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCEEEE
ETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
EEEEEEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEECHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGKENV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKTNPTIALVAGEVSGDILGAGLIRQLKAHYPNARFIGIAGPRMLAEGCETLVDMEELS
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHH
VMGLAEILKHLPRLLKIRKNVIQTMLQEKPDVYIGIDAPDFNLDVELKLKANGIKTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEE
SPSVWAWRQNRIHKIAKATHQVLAFLPFEKAFYDKFNVPCRFIGHTMADAIPLKPNRAEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
CQTLQIDPAQRYLAILVGSRGSEVEFLAEPFLKTALLLKEQFPDLQFLVPLVNEKRRIQF
HHEEECCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCEEEE
ETIKAKITPNLDLHLIDGNARQAMIAADATLLASGTAALEAMLCKSPMVVGYRMKPLTYF
EEEEEEECCCCEEEEECCCCCEEEEEECHHHHHCCHHHHHHHHHCCCCEEEEECHHHHHH
LAKRLVKTDYISLPNLLANEMLVPEMIQEECTPELLAEKLSVYLSDDESAVKNRHVLIQH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHHHHHHH
FTDLHQKIQCNADKQAAQAVIDLLEGKENV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA