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The map label for this gene is dfp

Identifier: 16272891

GI number: 16272891

Start: 1012136

End: 1013338

Strand: Direct

Name: dfp

Synonym: HI0953

Alternate gene names: 16272891

Gene position: 1012136-1013338 (Clockwise)

Preceding gene: 16272882

Following gene: 16272892

Centisome position: 55.3

GC content: 39.57

Gene sequence:

>1203_bases
ATGAAATTAAACGGAAAGCATATTGTAGTTGGCATAACTGGCGGTATTGCAGCCTATAAAACAATAGAGTTGATTCGTTT
GTTACGCAAAGCAGAAGCTGAAGTACGTGTAGTATTAACCCCTGCTGCGGCAGAATTTGTTACGCCTTTGACACTTCAAG
CCATTTCTGGCAATGCTGTATCGCAATCTTTACTTGATCCACAAGCAGAGCTGGCAATGGGGCATATTGAACTTGCCAAA
TGGGCTGATGCCATTATTATTGCGCCAGCTAGTGCAGATTTTATCGCCCGTCTTACTATTGGCATGGCGAATGATTTACT
TTCAACAATTTGTCTTGCGACTAATGCGCCAATTTTTCTTGCGCCAGCAATGAATCAGCAGATGTATCACCAATCCATTA
CTCAACAAAATTTAACGACTCTTCAAACACGTGGGATTGAGCTTATCGGCCCCAATAGTGGTTTTCAAGCTTGCGGCGAT
ATGGGGAAAGGGCGTATGTCAGAACCAGAGGAAATTTTTACCGCACTTTCTGACTTTTTCTCTCAAAAACAAGATCTACA
AGGATTAAATGTTTCCATTACAGCAGGCCCAACGCGTGAGGCAATCGATCCTGTTCGTTATATTTCTAACCATAGTTCAG
GGAAAATGGGGTTTGCGATTGCTGAAGCATTTGCCAAACGAGGGGCGAACGTCACGCTGATTGCAGGGCCAGTGAATTTA
ACAACACCAAAAAATGTAAATCGAATTAATGTCATCTCAGCACAAGAAATGTGGCAAGCCTCTCTTGAAAGTGCGGTAAA
AAATCAAATTTTTATTGGTTGTGCGGCTGTTGCTGATTACAGAGTAACTGAAGTTGCTGAGCAAAAAATCAAAAAATCTG
GCGATGAAATATCTATCAAATTAATTAAAAATCCTGATATTATCTCAGATGTAGGACATTTAAAAACACATCGTCCCTTT
ACTGTTGGATTTGCGGCTGAAACCCAAAATGTTGATGATTATGCAAAAGATAAACTTGAACGCAAAAATCTTGATATGAT
TTGTGCCAACGATGTATCTGGCGGACAAGTTTTTAACGCTGATGAAAATGCCTTGCAGCTTTTTTGGAAAAATGGTCATA
AAAAATTATCGCTAAAATCAAAAGTAGAACTTGCCGCTGATTTAGTCAATGAAATCATCGAACGCTATCAAAAAACCTTA
TAA

Upstream 100 bases:

>100_bases
TTCAAAATCTGCGATGCATATCGTAAAAATAGCGTTGGGCATTCAATAAAATTAAAGTAAAATAACGAAATTGTGGATAA
GTACTAACAAAGGTTAAAAC

Downstream 100 bases:

>100_bases
TTCCAACCGTACTTTTACCTAAAAATGAATTTCAAACGGAGTATTAAATGAAAAAAATTGACGTAAAAATTTTAGATTCT
CGCATTGGTAATGAATTTCC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVSQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFFSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL

Sequences:

>Translated_400_residues
MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVSQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFFSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
>Mature_400_residues
MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVSQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFFSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=61.0421836228288, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17560194, Length=193, Percent_Identity=29.0155440414508, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=30.8108108108108, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=29.5698924731183, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COABC_HAEIN (P44953)

Other databases:

- EMBL:   L42023
- PIR:   G64104
- RefSeq:   NP_439114.1
- ProteinModelPortal:   P44953
- SMR:   P44953
- GeneID:   949948
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0953
- NMPDR:   fig|71421.1.peg.920
- TIGR:   HI_0953
- HOGENOM:   HBG523890
- OMA:   VTSGPTH
- ProtClustDB:   PRK05579
- BioCyc:   HINF71421:HI_0953-MONOMER
- BRENDA:   4.1.1.36
- BRENDA:   6.3.2.5
- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382
- Gene3D:   G3DSA:3.40.50.10300
- Gene3D:   G3DSA:3.40.50.1950
- TIGRFAMs:   TIGR00521

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein; SSF102645 DNA/pantothenate-metab_flavo_C; SSF52507 Flavoprotein

EC number: =4.1.1.36; =6.3.2.5

Molecular weight: Translated: 43401; Mature: 43401

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: ACT_SITE 158-158 BINDING 125-125 BINDING 279-279 BINDING 289-289 BINDING 338-338 BINDING 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEECCCHH
SQSLLDPQAELAMGHIELAKWADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFL
HHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGDMGKGRMSEPEEIFTALSDFF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
SQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNL
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCEEC
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIK
CCCCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
LIKNPDIISDVGHLKTHRPFTVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNA
EECCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECC
DENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
CCHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEECCCHH
SQSLLDPQAELAMGHIELAKWADAIIIAPASADFIARLTIGMANDLLSTICLATNAPIFL
HHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGDMGKGRMSEPEEIFTALSDFF
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
SQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLIAGPVNL
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCEEC
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVTEVAEQKIKKSGDEISIK
CCCCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
LIKNPDIISDVGHLKTHRPFTVGFAAETQNVDDYAKDKLERKNLDMICANDVSGGQVFNA
EECCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECC
DENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
CCHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800