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Identifier: 16272887

GI number: 16272887

Start: 1008963

End: 1010327

Strand: Reverse

Name: dat

Synonym: HI0949

Alternate gene names: 16272887

Gene position: 1010327-1008963 (Counterclockwise)

Preceding gene: 16272888

Following gene: 16272886

Centisome position: 55.2

GC content: 43.0

Gene sequence:

>1365_bases
ATGACAATGATTACCCCTGTACAAGCAATTCTTGCTTCAAACCAACATTTTTTAGATCGCCAAGATGTAATGGAATCCAA
CGTACGTAGTTATCCTCGTAAATTACCTTTTGCCTATGCAAAAGCACAAGGCTGTTGGGTTACTGATGTTGAAGGTAATG
AATACCTAGACTTTTTAGCAGGCGCAGGAACCCTTGCATTAGGACATAATCATCCTATATTAATGCAAGCCATTAAAGAC
GTATTAGATAGCGGATTGCCGTTACACACTTTAGATTTAACCACTCCACTTAAAGATGCGTTTAGTGAAGAATTATTGTC
ATTCTTCCCGAAAGATAAATATATCTTACAATTCACAGGCCCTTCTGGTGCAGATGCAAATGAAGCAGCCATCAAATTAG
CGAAAACTTACACAGGGCGTGGCAATATCATTGCTTTCTCTGGCGGTTTTCACGGTATGACCCAAGGGGCATTAGCCTTA
ACGGGTAATCTTGGTGCAAAAAATGCCGTTGAAAATTTAATGCCTGGCGTACAATTTATGCCATATCCACACGAATACCG
CTGCCCATTTGGCATTGGTGGCGAAGCGGGTGCGAAAGCAGTTGAACAATACTTTGAAAACTTCATCGAAGATGTAGAAA
GTGGCGTAGTAAAACCAGCTGCAGTAATTTTAGAAGCAATCCAAGGAGAAGGCGGCGTTGTTTCAGCACCAATAAGCTTC
TTACAAAAAGTACGTGAAGTAACCCAAAAACACGGCATTTTAATGATCGTCGATGAAGTGCAAGCTGGTTTCTGCCGTTC
TGGAAGAATGTTCGCCTTTGAACACGCAGGCATTGAGCCTGATATTATTGTGATGTCAAAAGCAGTTGGTGGCAGCTTAC
CATTAGCTGTATTAGCTATTCGTAAAGAATTTGATGCTTGGCAACCTGCAGGACATACAGGTACATTTCGTGGCAATCAA
TTAGCGATGGCGACAGGCTATGCTTCACTTAAAATTATGCGTGATGAAAACCTCGCACAAAATGCCCAAGAGCGTGGTGA
ATACTTAACCAACGCATTACGTGAATTAAGCAAAGAATATCCGTGCATCGGCAACGTACGTGGTCGTGGCTTAATGATGG
GGATCGATATTGTAGACGAACGCCAATCGAAAGATGCGACAGGGGCTTACCCACGCGATTGTGAATTAGCGGCAGCAATC
CAAAAAGCTTGCTTCAAAAACAAACTCTTGCTCGAACGTGGCGGACGCGGTGGCAACGTGGTTCGCGTGCTTTGTGCGGT
AAACATCAACCAAAGTGAATGTGAAGAGTTCATCAAACGCTTCAAACAATCTGTTGTAGACGCATTGAAAGTGGTGCGTA
GTTAA

Upstream 100 bases:

>100_bases
GCGAGTCAAATGCCCTATGTGTCTGTTTTATAAACAGTAAATTTATCGCAAGGCACCCGACTTATTTTTTTTCACCTCTT
TTAGAAGGTTTTAATCAAAA

Downstream 100 bases:

>100_bases
TTAAAAGCGGTCTGATTTTGCAAATGTTTTGCGAATTTTGACCGCTTGTAAATTCAAAATGGTAGGGAAATCCCACCTTT
TTTCTACTCAACTGTATAAA

Product: diaminobutyrate--2-oxoglutarate aminotransferase

Products: NA

Alternate protein names: Diaminobutyrate transaminase; L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; DABA aminotransferase; DABA-AT; L-diaminobutyric acid transaminase

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTMITPVQAILASNQHFLDRQDVMESNVRSYPRKLPFAYAKAQGCWVTDVEGNEYLDFLAGAGTLALGHNHPILMQAIKD
VLDSGLPLHTLDLTTPLKDAFSEELLSFFPKDKYILQFTGPSGADANEAAIKLAKTYTGRGNIIAFSGGFHGMTQGALAL
TGNLGAKNAVENLMPGVQFMPYPHEYRCPFGIGGEAGAKAVEQYFENFIEDVESGVVKPAAVILEAIQGEGGVVSAPISF
LQKVREVTQKHGILMIVDEVQAGFCRSGRMFAFEHAGIEPDIIVMSKAVGGSLPLAVLAIRKEFDAWQPAGHTGTFRGNQ
LAMATGYASLKIMRDENLAQNAQERGEYLTNALRELSKEYPCIGNVRGRGLMMGIDIVDERQSKDATGAYPRDCELAAAI
QKACFKNKLLLERGGRGGNVVRVLCAVNINQSECEEFIKRFKQSVVDALKVVRS

Sequences:

>Translated_454_residues
MTMITPVQAILASNQHFLDRQDVMESNVRSYPRKLPFAYAKAQGCWVTDVEGNEYLDFLAGAGTLALGHNHPILMQAIKD
VLDSGLPLHTLDLTTPLKDAFSEELLSFFPKDKYILQFTGPSGADANEAAIKLAKTYTGRGNIIAFSGGFHGMTQGALAL
TGNLGAKNAVENLMPGVQFMPYPHEYRCPFGIGGEAGAKAVEQYFENFIEDVESGVVKPAAVILEAIQGEGGVVSAPISF
LQKVREVTQKHGILMIVDEVQAGFCRSGRMFAFEHAGIEPDIIVMSKAVGGSLPLAVLAIRKEFDAWQPAGHTGTFRGNQ
LAMATGYASLKIMRDENLAQNAQERGEYLTNALRELSKEYPCIGNVRGRGLMMGIDIVDERQSKDATGAYPRDCELAAAI
QKACFKNKLLLERGGRGGNVVRVLCAVNINQSECEEFIKRFKQSVVDALKVVRS
>Mature_453_residues
TMITPVQAILASNQHFLDRQDVMESNVRSYPRKLPFAYAKAQGCWVTDVEGNEYLDFLAGAGTLALGHNHPILMQAIKDV
LDSGLPLHTLDLTTPLKDAFSEELLSFFPKDKYILQFTGPSGADANEAAIKLAKTYTGRGNIIAFSGGFHGMTQGALALT
GNLGAKNAVENLMPGVQFMPYPHEYRCPFGIGGEAGAKAVEQYFENFIEDVESGVVKPAAVILEAIQGEGGVVSAPISFL
QKVREVTQKHGILMIVDEVQAGFCRSGRMFAFEHAGIEPDIIVMSKAVGGSLPLAVLAIRKEFDAWQPAGHTGTFRGNQL
AMATGYASLKIMRDENLAQNAQERGEYLTNALRELSKEYPCIGNVRGRGLMMGIDIVDERQSKDATGAYPRDCELAAAIQ
KACFKNKLLLERGGRGGNVVRVLCAVNINQSECEEFIKRFKQSVVDALKVVRS

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=30.6603773584906, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4557809, Length=427, Percent_Identity=29.03981264637, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI24119277, Length=452, Percent_Identity=27.212389380531, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI37574042, Length=397, Percent_Identity=29.7229219143577, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI226442705, Length=396, Percent_Identity=29.040404040404, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI226442709, Length=329, Percent_Identity=31.306990881459, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI284507298, Length=340, Percent_Identity=29.1176470588235, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI188536080, Length=387, Percent_Identity=28.4237726098191, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38679950, Length=387, Percent_Identity=28.4237726098191, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38679946, Length=387, Percent_Identity=28.4237726098191, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1787560, Length=439, Percent_Identity=33.9407744874715, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789016, Length=440, Percent_Identity=31.8181818181818, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI145693181, Length=408, Percent_Identity=32.5980392156863, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=27.8177458033573, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1788044, Length=433, Percent_Identity=30.4849884526559, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=28.448275862069, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786991, Length=345, Percent_Identity=28.1159420289855, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=432, Percent_Identity=32.1759259259259, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=30.2272727272727, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=451, Percent_Identity=29.490022172949, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=443, Percent_Identity=27.5395033860045, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=26.3707571801567, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=375, Percent_Identity=32.5333333333333, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324432, Length=347, Percent_Identity=31.4121037463977, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321456, Length=454, Percent_Identity=27.0925110132159, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28574759, Length=425, Percent_Identity=30.8235294117647, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=30.5045871559633, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI21357415, Length=425, Percent_Identity=28.2352941176471, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=26.5909090909091, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281366494, Length=391, Percent_Identity=26.5984654731458, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667139, Length=391, Percent_Identity=26.5984654731458, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667143, Length=391, Percent_Identity=26.5984654731458, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAT_HAEIN (P44951)

Other databases:

- EMBL:   L42023
- PIR:   C64104
- RefSeq:   NP_439110.1
- ProteinModelPortal:   P44951
- SMR:   P44951
- GeneID:   949951
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0949
- NMPDR:   fig|71421.1.peg.916
- TIGR:   HI_0949
- HOGENOM:   HBG725944
- OMA:   QFTGPSG
- ProtClustDB:   PRK06931
- BioCyc:   HINF71421:HI_0949-MONOMER
- BRENDA:   2.6.1.76
- InterPro:   IPR005814
- InterPro:   IPR004637
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF7
- TIGRFAMs:   TIGR00709

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.76

Molecular weight: Translated: 49369; Mature: 49238

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMITPVQAILASNQHFLDRQDVMESNVRSYPRKLPFAYAKAQGCWVTDVEGNEYLDFLA
CCCCHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCEEEECCCCHHHHHHH
GAGTLALGHNHPILMQAIKDVLDSGLPLHTLDLTTPLKDAFSEELLSFFPKDKYILQFTG
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECC
PSGADANEAAIKLAKTYTGRGNIIAFSGGFHGMTQGALALTGNLGAKNAVENLMPGVQFM
CCCCCCHHHHHHHHHEECCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHCCCCEEC
PYPHEYRCPFGIGGEAGAKAVEQYFENFIEDVESGVVKPAAVILEAIQGEGGVVSAPISF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHH
LQKVREVTQKHGILMIVDEVQAGFCRSGRMFAFEHAGIEPDIIVMSKAVGGSLPLAVLAI
HHHHHHHHHHCCEEEEEECHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHH
RKEFDAWQPAGHTGTFRGNQLAMATGYASLKIMRDENLAQNAQERGEYLTNALRELSKEY
HHHHCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHC
PCIGNVRGRGLMMGIDIVDERQSKDATGAYPRDCELAAAIQKACFKNKLLLERGGRGGNV
CCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCE
VRVLCAVNINQSECEEFIKRFKQSVVDALKVVRS
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMITPVQAILASNQHFLDRQDVMESNVRSYPRKLPFAYAKAQGCWVTDVEGNEYLDFLA
CCCHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCEEEECCCCHHHHHHH
GAGTLALGHNHPILMQAIKDVLDSGLPLHTLDLTTPLKDAFSEELLSFFPKDKYILQFTG
CCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECC
PSGADANEAAIKLAKTYTGRGNIIAFSGGFHGMTQGALALTGNLGAKNAVENLMPGVQFM
CCCCCCHHHHHHHHHEECCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHCCCCEEC
PYPHEYRCPFGIGGEAGAKAVEQYFENFIEDVESGVVKPAAVILEAIQGEGGVVSAPISF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHH
LQKVREVTQKHGILMIVDEVQAGFCRSGRMFAFEHAGIEPDIIVMSKAVGGSLPLAVLAI
HHHHHHHHHHCCEEEEEECHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHH
RKEFDAWQPAGHTGTFRGNQLAMATGYASLKIMRDENLAQNAQERGEYLTNALRELSKEY
HHHHCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHC
PCIGNVRGRGLMMGIDIVDERQSKDATGAYPRDCELAAAIQKACFKNKLLLERGGRGGNV
CCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCE
VRVLCAVNINQSECEEFIKRFKQSVVDALKVVRS
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614