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The map label for this gene is ribD

Identifier: 16272881

GI number: 16272881

Start: 1003367

End: 1004485

Strand: Direct

Name: ribD

Synonym: HI0944

Alternate gene names: 16272881

Gene position: 1003367-1004485 (Clockwise)

Preceding gene: 16272880

Following gene: 16272882

Centisome position: 54.82

GC content: 40.66

Gene sequence:

>1119_bases
ATGCTTGAATTTTCCTCACAAGATTGCGTATTTATGCAACGTGCCTTAGATTTGGCAGCCAAAGGTCAATATACCACTAC
ACCGAACCCATCGGTGGGATGCGTATTGGTTAAAAATGGTGAAATTGTGGGGGAGGGCTTTCATTTTAAGGCAGGACAAC
CTCATGCTGAACGCGTTGCCTTAGCTCAAGCTGGTGAAAATGCTAAAGGAGCAACCGCTTACGTCACCTTAGAGCCTTGC
GCTCATTATGGTCGCACACCACCTTGTGCATTAGGATTAATTGAGGCGGGCGTAGTGAAAGTCATTGCGGCTATGCAAGA
TCCAAATCCTCAAGTCGCAGGAAAAGGTTTGAAAATGTTGTCTGATGCCGGTATCGAAAGTACGGTGAATTTATTGAACG
ATCAAGCGGAAAAAATAAATAAAGGTTTTTTAAAACGAATGCGTCAAGGTATGCCTTTTGTTCAACTAAAACTTGCCATG
AGTTTAGATGGACGAACTGCAATGGCAAGTGGAGAAAGTAAATGGATTACGGGCCCAGATGCTCGTTCGGACGTACAAAA
AATGCGAGCAAAATCATCCGCACTTTTATCTACTTCCACAACAGTCATTGCAGATGATCCAAGCCTTAATGTACGCTGGG
ACGAATTTCCTGAAAATCTTAAAACAGAATATAAAAAAGAATGGCTTCGCCAGCCTGTGCGAGTCATTTTAGATTCACAA
CATCGCATTCAGCCGACTCATAAACTTTTTTTAACCCATTCTCCCGTTTGGTTAGTCTCTAGTGAGCCACGAGATTTAAC
AGGCTTTCCTGATTTTTGTGAACAAATTATTTTTCCGAAAGAAAATTTACTAAAAGAATTAATGCGAGAACTGGGAAAAC
GACAAATCAATACCCTTTGGGTAGAAGCTGGAGCAAATTTATCGGGCAGTTTAATTGATGCGAAATTAGTGGATGAATTG
ATTATTTACATTGCGCCAAAATTACTTGGAGACAATGCTCGTGGTCTATGCCAATTACCGAATTTAACTAAACTTGCTGA
TGCACCATTATGGCAACTCAATGAATTAGAACAAATCGGTGACGATATAAAATTAACTTACACACCGAAAGGAGTCTAA

Upstream 100 bases:

>100_bases
AACTCGATAAAGTGGCTTATATTCGTTTTGCATCAGTCTATTTAAGTTTTGATGATATTGATCAATTTACTATCGAAATT
GAAAAATTAAAGGATTAATT

Downstream 100 bases:

>100_bases
ATGCTTAAAAAACTTTTCCATTCCGCACTTTGGGGCTTGGCTGCTGCGGGCGTGATTTTGTTTGCGGTTCCAAGACTGAA
TAACAGCAATATCTTCACTT

Product: riboflavin biosynthesis protein

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLEFSSQDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVALAQAGENAKGATAYVTLEPC
AHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKMLSDAGIESTVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAM
SLDGRTAMASGESKWITGPDARSDVQKMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQ
HRIQPTHKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLWVEAGANLSGSLIDAKLVDEL
IIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIGDDIKLTYTPKGV

Sequences:

>Translated_372_residues
MLEFSSQDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVALAQAGENAKGATAYVTLEPC
AHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKMLSDAGIESTVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAM
SLDGRTAMASGESKWITGPDARSDVQKMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQ
HRIQPTHKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLWVEAGANLSGSLIDAKLVDEL
IIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIGDDIKLTYTPKGV
>Mature_372_residues
MLEFSSQDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVALAQAGENAKGATAYVTLEPC
AHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKMLSDAGIESTVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAM
SLDGRTAMASGESKWITGPDARSDVQKMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQ
HRIQPTHKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLWVEAGANLSGSLIDAKLVDEL
IIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIGDDIKLTYTPKGV

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family

Homologues:

Organism=Escherichia coli, GI1786616, Length=362, Percent_Identity=56.9060773480663, Blast_Score=435, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBD_HAEIN (P44326)

Other databases:

- EMBL:   L42023
- PIR:   H64103
- RefSeq:   NP_439104.1
- ProteinModelPortal:   P44326
- SMR:   P44326
- GeneID:   949944
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0944
- NMPDR:   fig|71421.1.peg.910
- TIGR:   HI_0944
- HOGENOM:   HBG668075
- OMA:   KRMEHGL
- ProtClustDB:   CLSK870233
- BioCyc:   HINF71421:HI_0944-MONOMER
- BRENDA:   1.1.1.193
- BRENDA:   3.5.4.26
- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734
- PANTHER:   PTHR11079:SF10
- TIGRFAMs:   TIGR00326
- TIGRFAMs:   TIGR00227

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C; SSF53927 Cytidine_deaminase-like

EC number: =3.5.4.26; =1.1.1.193

Molecular weight: Translated: 40932; Mature: 40932

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: ACT_SITE 57-57 BINDING 159-159 BINDING 173-173 BINDING 175-175 BINDING 189-189 BINDING 201-201 BINDING 205-205 BINDING 209-209 BINDING 212-212 BINDING 239-239 BINDING 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFSSQDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEECCEEECCCCCHHHHHH
LAQAGENAKGATAYVTLEPCAHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKML
HHHCCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHH
SDAGIESTVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAMSLDGRTAMASGESKWITGPD
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCCCCCCC
ARSDVQKMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQ
HHHHHHHHHHHHHHHEECCEEEEECCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHCCC
HRIQPTHKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLW
CCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEE
VEAGANLSGSLIDAKLVDELIIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCHHHHHHHHCC
DDIKLTYTPKGV
CCEEEEECCCCC
>Mature Secondary Structure
MLEFSSQDCVFMQRALDLAAKGQYTTTPNPSVGCVLVKNGEIVGEGFHFKAGQPHAERVA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEECCEEECCCCCHHHHHH
LAQAGENAKGATAYVTLEPCAHYGRTPPCALGLIEAGVVKVIAAMQDPNPQVAGKGLKML
HHHCCCCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHH
SDAGIESTVNLLNDQAEKINKGFLKRMRQGMPFVQLKLAMSLDGRTAMASGESKWITGPD
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCCCCCCC
ARSDVQKMRAKSSALLSTSTTVIADDPSLNVRWDEFPENLKTEYKKEWLRQPVRVILDSQ
HHHHHHHHHHHHHHHEECCEEEEECCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHCCC
HRIQPTHKLFLTHSPVWLVSSEPRDLTGFPDFCEQIIFPKENLLKELMRELGKRQINTLW
CCCCCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEE
VEAGANLSGSLIDAKLVDELIIYIAPKLLGDNARGLCQLPNLTKLADAPLWQLNELEQIG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCHHHHHHHHCC
DDIKLTYTPKGV
CCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800